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Keyword: heart
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Articles
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
... in obese insulin-resistant rats. We hypothesized that Mdivi1 and M1 protect heart against obese insulin-resistant condition, but also there will be greater improvement using Mdivi1 and M1 as a combined treatment. Wistar rats ( n =56, male) were randomly assigned to a high-fat diet (HFD) and normal...
Articles
Clin Sci (Lond) (2019) 133 (3): 497–513.
Published: 12 February 2019
... 01 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Acute myocardial infarction Heart Ischemia-reperfusion injury Mitochondrial dynamics Mitochondrial fusion An imbalance of mitochondrial dynamics has been shown to be...
Articles
Clin Sci (Lond) (2018) 132 (15): 1669–1683.
Published: 14 August 2018
... heart was removed to determine infarct size, mitochondrial function, mitochondrial dynamics, and apoptosis. Our results showed that Mdivi-1 given prior to ischemia, exerted the highest level of cardioprotection quantitated through the attenuated incidence of arrhythmia, reduced infarct size, improved...
Articles
Clin Sci (Lond) (2017) 131 (9): 865–881.
Published: 19 April 2017
... the mitochondrial permeability transition pore (MPTP) to opening, and infarct size (IS) in hearts of spontaneously hypertensive rats (SHR) and the conplastic SHR-mt BN strain, characterized by the selective replacement of the mitochondrial genome of SHR with that of the more ischaemia-resistant brown...
Articles
Clin Sci (Lond) (2016) 130 (10): 747–759.
Published: 01 April 2016
...Glenna C.L. Bett Disruption of cardiac electrical activity resulting in palpitations and syncope is often an early symptom of pregnancy. Pregnancy is a time of dramatic and dynamic physiological and hormonal changes during which numerous demands are placed on the heart. These changes result in...
Articles
Clin Sci (Lond) (2011) 121 (9): 405–413.
Published: 12 July 2011
... subchronic models respectively. Mice received either CsA (1 mg/kg of body weight, intraperitoneal on alternate days) or saline until follow-up. Heart function was evaluated by echocardiography. Mitochondrial measurements included oxygen consumption, membrane potential and externally added calcium-induced...
Articles
Clin Sci (Lond) (2009) 116 (9): 697–712.
Published: 02 April 2009
... essential for autophagy in yeast, the discovery of human orthologues and the definition of signalling pathways regulating autophagy have accelerated our molecular understanding and interest in this fundamental process. A growing body of evidence indicates that autophagy is associated with heart disease...
Articles
Clin Sci (Lond) (2005) 109 (3): 277–286.
Published: 24 August 2005
... formation was measured by ELISA. Rats fed an iron-deficient diet exhibited increased heart weight and size compared with the control group. Heart width, length and ventricular free wall thickness were similar between the two groups. However, the left ventricular dimension and chamber volume were...
Articles
Clin Sci (Lond) (2004) 107 (5): 467–475.
Published: 26 October 2004
... 2004 5 7 2004 The Biochemical Society 2004 adenosine contractile function endothelin endothelin A receptor haemodynamics heart The effects of the most potent endogenous vasoconstrictor ET (endothelin)-1 [ 1 ] are mediated via ET A [ 2 ] and ET B [ 3 ] receptors. Since ET...
Articles
Clin Sci (Lond) (2004) 106 (3): 337–343.
Published: 01 March 2004
...Leila M. M. PEREIRA; Daniele G. BEZERRA; Denise L. MACHADO; Carlos A. MANDARIM-DE-LACERDA Stereological structural alterations of the heart and kidney were studied in four groups ( n =5) of spontaneously hypertensive rats (SHRs) treated for 30 days: (i) control, (ii) N G -nitro- L -arginine methyl...
Articles
Clin Sci (Lond) (2003) 104 (4): 429–436.
Published: 20 March 2003
...Christopher J. CHARLES; John M. ELLIOTT; M. Gary NICHOLLS; Miriam T. RADEMAKER; A. Mark RICHARDS The impaired ability to excrete sodium is a key feature of established congestive heart failure and is also apparent in asymptomatic left ventricular (LV) impairment. However, few studies have examined...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 152S–157S.
Published: 01 September 2002
...Motoyuki IEMITSU; Takashi MIYAUCHI; Seiji MAEDA; Takumi TANABE; Yoko IRUKAYAMA-TOMOBE; Katsutoshi GOTO; Mitsuo MATSUDA; Iwao YAMAGUCHI Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects on heart and induces...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 357S–362S.
Published: 01 September 2002
... adenovirus aorta heart lung mRNA PD156707 ...
Articles
Clin Sci (Lond) (2002) 102 (2): 241–246.
Published: 10 January 2002
...) were seen in women only ( P < 0.05 compared with men). Blood pressure and heart rate were not altered in either sex. Whole-body insulin-mediated glucose uptake and forearm glucose uptake did not differ between the sexes, and the ability of insulin to enhance endothelium-dependent vasodilatation (+19...
Articles
Clin Sci (Lond) (2001) 100 (5): 529–537.
Published: 09 April 2001
... diastolic blood pressure throughout the exercise period, but heart rate drifted upwards from 141±2 beats/min after 30 min to 154±3 beats/min after 150 min ( P < 0.05). There was a small decline (8%; P < 0.05) in end-diastolic volume at 150 min. No changes were observed in left ventricular ejection...
Articles
Clin Sci (Lond) (2000) 99 (6): 547–554.
Published: 23 November 2000
... J.Lee@shef.ac.uk ). 8 3 2000 5 7 2000 15 8 2000 The Biochemical Society and the Medical Research Society © 2000 2000 arrhythmias heart inotropic agents intracellular Ca2+ myofilaments sarcoplasmic reticulum 547Clinical Science (2000) 99, 547 554 (Printed in Great...
Articles
Clin Sci (Lond) (2000) 98 (6): 703–711.
Published: 10 May 2000
...Christopher J. CHARLES; John M. ELLIOTT; M. Gary NICHOLLS; Miriam T. RADEMAKER; Mark RICHARDS There are few stable and reproducible large-animal models of chronic heart failure produced by ischaemic damage to the myocardium. Here we characterize a novel method of inducing myocardial damage in...
Articles
Clin Sci (Lond) (1998) 95 (1): 3–17.
Published: 01 July 1998
... correlated to the concomitant reduction in ejection fraction. The regulatory and pathophysiological changes in the activity and concentration of Na + ,K + -pumps are important for the contractile function of skeletal muscle and heart as well as for K + homoeostasis and the response to digitalization...
Articles
Clin Sci (Lond) (1997) 93 (5): 401–411.
Published: 01 November 1997
..., characterized by fibrinoid necrosis. This condition was absent in drug-treated animals, which presented minor signs of ischaemic lesion. Heart hypertrophy, when heart weight was expressed as a percentage of body weight, was similar in saline-, delapril- or indapamide-treated rats. At variance with this, in...
Articles
Clin Sci (Lond) (1995) 89 (2): 145–154.
Published: 01 August 1995
... nervous activity in healthy, lean subjects. 2. In nine male subjects, noradrenaline spillover was measured from the heart, kidney and liver using isotope dilution, both while fasting and after consumption of a high-energy liquid meal of composition 53% carbohydrate, 32% fat and 15% protein (energy value...
Articles
Clin Sci (Lond) (1995) 88 (3): 257–262.
Published: 01 March 1995
... current between heart muscle cells. 3. In this article, some of the contributions to this field by the author and his collaborators are summarized. Studies using confocal microscopy and digital imaging techniques to characterize the three-dimensional organization of electrical contacts between myocytes in...
Articles
Clin Sci (Lond) (1991) 81 (5): 611–619.
Published: 01 November 1991
... the whole body. k s was selectively depressed in skeletal muscles, mainly owing to a reduced k RNA , and was not modified in heart, liver and skin. The contribution of skin to whole-body protein synthesis increased by 39%. 3. During the phase of protein sparing (5 days of fasting), k d in the whole...
Articles
Clin Sci (Lond) (1988) 74 (3): 269–274.
Published: 01 March 1988
...A. M. Dart; R. A. Riemersma 1. Reperfusion of the globally ischaemic isolated rat heart is associated with an enhanced overflow of endogenous noradrenaline (NA) after ischaemic periods of 20, 40 or 60 min but not of 10 min. 2. Reperfusion NA overflow, after 40 min of ischaemia, is suppressed by...
Articles
Clin Sci (Lond) (1987) 72 (3): 271–275.
Published: 01 March 1987
... to the heart or is a generalized phenomenon in this hypertensive model. 2. The ventricles, kidney and liver of newborn SHR, Wistar and Wistar-Kyoto (WKY) rats were analysed for their protein and DNA content. 3. Total organ weight and the organ/body weight ratio of the heart and kidney but not of the...
Articles
Clin Sci (Lond) (1986) 71 (4): 449–451.
Published: 01 October 1986
... to the sinoatrial node was occluded for periods of 1–3 min during this intermittent vagal stimulation. 3. Vagal action on heart rate was potentiated during ischaemia of the sino-atrial node. 21 1 1986 19 6 1986 © 1986 The Biochemical Society and the Medical Research Society 1986...
Articles
Clin Sci (Lond) (1986) 70 (1): 7–12.
Published: 01 January 1986
... in treatment of circulatory and metabolic disturbances in cardiac failure. 24 6 1985 16 7 1985 © 1986 The Biochemical Society and the Medical Research Society 1986 cardiac function exogenous glutamic acid heart myocardial metabolism postoperative cardiac failure Clinical...
Articles
Clin Sci (Lond) (1984) 67 (5): 535–540.
Published: 01 November 1984
... 1984 17 5 1984 © 1984 The Biochemical Society and the Medical Research Society 1984 calcium-binding proteins heart hypertension Na + , K + -ATPase ouabain Clinical Science (1984) 61, 535-540 535 Calmodulin reduces ouabain-sensitive AT Pase of cardiac sarcolemmal membranes: high...
Articles
Clin Sci (Lond) (1983) 65 (6): 579–588.
Published: 01 December 1983
... therapy on the early electrical changes in the intact heart. 28 4 1983 21 6 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 electrophysiology heart myocardial ischaemia Clinical Science (1983) 65, 579-588 579 Study of the electrophysiological effects...
Articles
Clin Sci (Lond) (1982) 63 (s8): 383s–385s.
Published: 01 October 1982
... higher, heart rates were slightly higher, and heart weight/body weight ratios were higher in SHR. 3. Vascular dimensions were determined in a small sample of those rats, and the data there also indicate hypertrophy to some degree: the ratio of wall thickness/lumen radius was higher in SHR, tangential...
Articles
Clin Sci (Lond) (1982) 62 (3): 337–339.
Published: 01 March 1982
...F. Y. Leung; A. R. Henderson 1. Cytoplasmic aspartate aminotransferase was isolated and purified from human heart with a final specific activity of 236 units/mg of protein. 2. Three distinct peaks of aspartate aminotransferase activity were detected by isoelectric focusing with isoelectric points...
Articles
Clin Sci (Lond) (1981) 61 (5): 585–590.
Published: 01 November 1981
... release and extraction. The estimated contribution of various organs to the noradrenaline concentrations in their venous effluent was: heart. 21%; kidney 47%; legs 68%. 5. This pattern of A—V difference proved a positive diagnostic feature for non-tumour patients since it was not found even in the...
Articles
Clin Sci (Lond) (1981) 61 (s7): 45s–48s.
Published: 01 January 1981
...Marie-Gabrielle Pernollet; Marie-Aude Devynck; P. Meyer 1. Calcium handling by heart sarcolemmal vesicles from young spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) control rats were compared. 2. Calcium binding was significantly altered in SHR membranes at the...
Articles
Clin Sci (Lond) (1981) 61 (s7): 181s–183s.
Published: 01 January 1981
... cardiac sensory nerve endings, at doses devoid of systemic haemodynamic effects. 2. In conscious dogs with implanted catheters bradykinin (100 ng/kg) injected into a cannulated branch of the left coronary artery induced significant ( P < 0.01, n = 5) reflex increases in mean arterial pressure and heart...
Articles
Clin Sci (Lond) (1981) 60 (1): 33–40.
Published: 01 January 1981
...K. L. Evemy; P. Cummins; W. A. Littler 1. The effect of prolonged administration of β-adrenoreceptor-blocking agents was studied in growing rabbits. Equivalent doses of propranolol and timolol were given parenterally for 8 weeks. 2. Animals given propranolol had a significantly lower heart rate...
Articles
Clin Sci (Lond) (1980) 59 (3): 207–209.
Published: 01 September 1980
... last dose hearts were removed and subjected to aerobic perfusion, ischaemia and reperfusion. Rhythm disturbances were measured and compared with corresponding values in control hearts from the control untreated animals. 3. Three to 6 days after termination of drug administration a pronounced increase...
Articles
Clin Sci (Lond) (1980) 58 (6): 501–506.
Published: 01 June 1980
... relaxed dogs. 3. The increased tissue requirement for oxygen was met both by increased cardiac output and increased oxygen extraction from haemoglobin. 4. Oxygen utilization remained adequate in hypothermia, as shown by the absence of hypoxic acidosis. 5. Heart rate fell during cooling and stroke volume...
Articles
Clin Sci (Lond) (1980) 59 (s6): 169s–170s.
Published: 01 January 1980
...A. A. MacPhee; H. L. Blakesley; Karen A. Graci; E. D. Frohlich; F. E. Cole 1. Altered adrenergic responsiveness of hearts and blood vessels occurs in both experimental and clinical hypertension. 2. Since salt excess aggravates both types of hypertension, we investigated β-adrenoreceptor properties...
Articles
Clin Sci (Lond) (1980) 59 (s6): 415s–417s.
Published: 01 January 1980
... and the Medical Research Society 1980 cardiac adaptation heart ventricular weight ratio ClinicaZScience (1980) 5 9 , 4 1 5 ~ 4 1 7 ~ 415s Left/right ventricular weight ratio: an estimate of cardiac adaptation to hypertension M A R G A R E T A H A L L B A C K - N O R D L A N D E R...
Articles
Clin Sci (Lond) (1979) 57 (s5): 39s–41s.
Published: 01 January 1979
... protein synthesis at this age. 4. Both β-adrenergic antagonists prevented the hypertrophy of aorta and mesenteric artery but not in heart. © 1979 The Biochemical Society and the Medical Research Society 1979 aorta, artery heart metoprolol propranolol vena cava Clinical Science (1979) 57.399...
Articles
Clin Sci Mol Med (1976) 51 (s3): 159s–162s.
Published: 01 January 1976
...C. E. Hall; S. Ayachi; O. Hall 1. Bilateral compression of adrenal glands combined with unilateral nephrectomy and followed by imposition of a high sodium chloride intake caused severe hypertension in all rats, accompanied by enlargement of the heart, kidneys and adrenal glands, atrophy of the...
Articles
Clin Sci Mol Med (1975) 49 (4): 337–341.
Published: 01 October 1975
...M. R. Moore; P. A. Meredith; A. Goldberg; K. E. Carr; P. G. Toner; T. D. V. Lawrie 1. There is no known cause for the increased mortality due to ischaemic heart disease in soft water areas. Since the lead concentration of soft water is elevated in houses with lead plumbing, studies have been...