1-50 of 168
Keywords: heart failure
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2024) 138 (10): 573–597.
Published: 22 May 2024
... transplantation from the left ventricle of end-stage heart failure patients. Samples were collected in the operating room and transported in ice-cold St. Thomas’ cardioplegia solution, flash frozen within 20 min of excision, and stored at −80°C prior to utilisation. Control left ventricular tissues were collected...
Includes: Supplementary data
Articles
Articles
Clin Sci (Lond) (2023) 137 (16): 1225–1247.
Published: 22 August 2023
...Charles Duncan Smart; Meena S. Madhur Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of new heart failure diagnoses and continues to increase in prevalence in the United States. Importantly, HFpEF is a highly morbid, heterogeneous syndrome lacking effective...
Articles
Articles
Articles
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
..., heart failure with preserved ejection fraction (HFpEF). In addition, emerging evidence indicates that obesity increases the risk of both hypertension and heart failure in pregnancy. This review will summarize clinical and experimental data on the female-specific prevalence and mechanisms of hypertension...
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2021) 135 (1): 71–100.
Published: 06 January 2021
... systolic dysfunction (LVSD) and heart failure as well as arterial and venous thromboembolism, QTc interval prolongation and arrhythmia. The mechanisms behind the development of VEGFI-associated LVSD and heart failure likely involve the combination of a number of myocardial insults. These include direct...
Articles
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2020) 134 (19): 2595–2622.
Published: 14 October 2020
... pathological hypertrophy [ 65 ], suggesting that augmentation of the PI3Kα signalling pathway may improve the functionality of a diseased heart and may potentially be used for the treatment of heart failure. Activation of PI3Kα has been shown to improve the function of failing hearts, through exercise-induced...
Articles
Clin Sci (Lond) (2020) 134 (19): 2623–2643.
Published: 14 October 2020
... in humans with systolic heart failure. NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis...
Articles
Articles
Clin Sci (Lond) (2020) 134 (7): 827–851.
Published: 09 April 2020
... are at a high risk of cardiovascular complications ranging from microvascular dysfunction to cardiometabolic syndromes including heart failure. Despite significant advances in the standards of care for obese and diabetic patients, current therapeutic approaches are not always successful in averting...
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2018) 132 (1): 85–91.
Published: 11 January 2018
... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics Correspondence: W.H. Wilson Tang ( [email protected] ) 02 09 2017 15 11 2017 20 11...
Articles
Clin Sci (Lond) (2017) 131 (18): 2319–2345.
Published: 25 August 2017
... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...
Articles
Clin Sci (Lond) (2017) 131 (16): 2063–2078.
Published: 24 July 2017
... Society 2017 Cardiometabolic diseases cardiovascular physiology heart failure mitochondria pulmonary hypertension sirtuins Cardiometabolic disease (CMD) or cardiometabolic syndrome, remains one of the leading causes of morbidity and mortality worldwide. CMD is a disease entity...
Articles
Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... concomitantly with changes in cardiac function. In heart failure, FA oxidation is decreased, correlating with systolic dysfunction and hypertrophy. In contrast, in type 2 diabetes, FA oxidation and triglyceride storage are increased, and correlate with diastolic dysfunction and insulin resistance. Therefore...
Articles
Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
... Ca 2+ release channel inactivation, impaired cardiac contractility with the development of heart failure [ 42 ]. Similarly, mutations in JPH2 were found in 0.8% of unrelated patients diagnosed with HCM [ 43 ]. Correspondence: Filio Billia ( [email protected] ) 5 9 2016 15 2...
Articles
Articles
Articles
Clin Sci (Lond) (2017) 131 (6): 439–448.
Published: 06 March 2017
...Michael D. Fridman; Seema Mital In 2015, President Obama launched the Precision Medicine Initiative (PMI), which introduced new funding to a method of research with the potential to study rare and complex diseases. Paediatric heart failure, a heterogeneous syndrome affecting approximately 1...
Articles
Clin Sci (Lond) (2017) 131 (5): 395–409.
Published: 17 February 2017
... accuracy, available and newly developing therapeutics, as well as a brief biochemical and biophysical background of TTR amyloidogenesis. ATTR amyloidosis cardiac amyloidosis cardiomyopathy heart failure polyneuropathy transthyretin amyloidosis There is a growing awareness...
Articles
Clin Sci (Lond) (2017) 131 (2): 113–121.
Published: 14 December 2016
...Paaladinesh Thavendiranathan; Mark T. Nolan Heart disease and cancer are the two leading causes of mortality globally. Cardiovascular complications of cancer therapy significantly contribute to the global burden of cardiovascular disease. Heart failure (HF) in particular is a relatively common...
Articles
Clin Sci (Lond) (2016) 130 (24): 2239–2244.
Published: 04 November 2016
...Mark J. Haykowsky; Rhys Beaudry; R. Matthew Brothers; Michael D. Nelson; Satyam Sarma; Andre La Gerche Breast cancer (BC) survival rates have improved during the past two decades and as a result older BC survivors are at increased risk of developing heart failure (HF). Although the HF phenotype...
Articles
Clin Sci (Lond) (2016) 130 (23): 2139–2149.
Published: 20 October 2016
... patients presented lower cardiomyocyte density ( P <0.001) and ejection fraction ( P <0.05), and higher troponin T levels ( P <0.05), prevalence of heart failure (HF; P <0.05) and NT-proBNP levels ( P <0.05) than those from group 1. miRNA expression profile analysed in 5 patients randomly...
Includes: Supplementary data
Articles
Articles
Clin Sci (Lond) (2016) 130 (8): 551–563.
Published: 08 March 2016
.... These differences can be found in all domains of cardiovascular health and disease, including heart rhythm, heart failure, coronary disease and valvular disease. Further understanding of gender differences in the heart is crucial for advancing our ability to maintain a healthy population and identify and treat...
Articles
Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...
Articles
Articles
Clin Sci (Lond) (2015) 129 (10): 851–862.
Published: 28 August 2015
... states, and in particular has recently become regarded as one of the best diagnostic biomarkers available for acute kidney injury. Nevertheless, the precise physiological effects of NGAL on the heart and the significance of their alterations during the development of heart failure are only now beginning...
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2014) 127 (2): 65–76.
Published: 17 March 2014
... exchange. This pathological process may also contribute to PH (pulmonary hypertension) due to LHD. Few clinical trials have specifically evaluated lung structural remodelling and the effect of related therapies in LHD. Currently approved treatment for chronic HF (heart failure) may have direct beneficial...
Articles
Clin Sci (Lond) (2014) 127 (1): 1–13.
Published: 10 March 2014
... in relation to potential contributory pathogenic effects in the setting of hypertension, ischaemic heart disease, AF (atrial fibrillation), LVH (LV hypertrophy), HF (heart failure) and the MS (metabolic syndrome), with evidence of several positive and interesting results. Figure 1 Schematic...
Articles
Articles
Clin Sci (Lond) (2013) 125 (7): 319–327.
Published: 07 June 2013
... endogenous activation induced pluripotent stem cell heart failure regeneration transplantation Ischaemic heart disease and resultant heart failure are the leading causes of death worldwide [ 1 ]. The ongoing loss of cardiomyocytes during and after ischaemic injury and replacement fibrosis...
Articles
Clin Sci (Lond) (2013) 124 (6): 391–401.
Published: 27 November 2012
... faecal peritonitis gene transcript heart failure sepsis • Myocardial function is depressed in sepsis and is an important prognosticator in patients. • Using a long-term fluid-resuscitated rat model of faecal peritonitis, we demonstrate that significant differences in stroke volume...
Includes: Supplementary data
Articles
Articles
Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... (AT 2 receptor) B 1 kinin receptor B 2 kinin receptor heart failure inflammation myocardial infarction renin–angiotensin system • CVD is the leading cause of death in the U.S.A. and worldwide. Activation of the RAS plays a crucial role in the pathophysiology of CVD and up until now...
Articles
Clin Sci (Lond) (2012) 123 (12): 659–668.
Published: 10 August 2012
.... Local paracrine effects in the gut through GC-C stimulation may have tumour-suppressing actions through the regulation of cell proliferation and metabolism. Although most information on this system has been derived from knockout models, recent human studies have indicated possible roles in heart failure...
Articles