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Articles

Sex differences in the chronic autoimmune response to myocardial infarction

Erin B. Taylor, Luciano D. Mendoza, Jayla D. Sandifer, Jemylle G. Morato, Nikaela M. Aitken, Katherine R. O'Quinn, Indu Raman, Chengsong Zhu, Robert W. Spitz, John E. Hall, Alan J. Mouton

Clin Sci (Lond) (2025) 139 (12): 627–648.

https://doi.org/10.1042/CS20243091

Published: 17 June 2025

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autoimmune disease inflammation heart failure myocardial infarction sex differences Myocardial infarction (MI) is one of the leading causes of heart failure and mortality due to cardiovascular disease worldwide [ 1...

View article titled, Sex differences in the chronic autoimmune response to myocardial infarction

Includes: Supplementary data

Articles

Increased absorptive transcytosis and tight junction weakness in heart failure are equally corrected by exercise training and losartan

Hiviny de Ataides Raquel, Mariana Makuch-Martins, Sany M. Perego, Gustavo S. Masson, Leonardo Jensen, Lisete C. Michelini

Clin Sci (Lond) (2025) 139 (11): 527–543.

https://doi.org/10.1042/CS20242965

Published: 29 May 2025

...Hiviny de Ataides Raquel; Mariana Makuch-Martins; Sany M. Perego; Gustavo S. Masson; Leonardo Jensen; Lisete C. Michelini Reduced ventricular function, renin–angiotensin system up-regulation, and sympathoexcitation are hallmarks of heart failure (HF). Recently, we showed that blood–brain barrier...

View article titled, Increased absorptive transcytosis and tight junction weakness in heart failure are equally corrected by exercise training and losartan

Articles

Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts

Bo Pan, Di Hu, Yao Wei Lu, Jing Luo, Xiao Hui Xu, Haipeng Guo, Rui Deng, Zhuomin Liang, Yi Wang, Qing Ma, John D. Mably, Jie Tian, Da-Zhi Wang

Clin Sci (Lond) (2025) 139 (05): 235–338.

https://doi.org/10.1042/CS20242397

Published: 11 March 2025

... cardiomyocytes in young adults (Trbp-cKOs). While Trbp-cKO mice did not display a detectable phenotype, under stress conditions induced by transverse aortic constriction pressure overload, they rapidly developed severe heart failure; this was associated with maladaptive cardiac remodeling and increased...

View article titled, Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts

Includes: Supplementary data

Articles

Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo

Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Sonia P. Chothani, Owen J.L. Rackham, Daniel N. Meijles, Philip R. Dash, Risto Kerkelä, Neil Ruparelia, Peter H. Sugden, Angela Clerk

Clin Sci (Lond) (2024) 138 (10): 573–597.

https://doi.org/10.1042/CS20240496

Published: 22 May 2024

... transplantation from the left ventricle of end-stage heart failure patients. Samples were collected in the operating room and transported in ice-cold St. Thomas’ cardioplegia solution, flash frozen within 20 min of excision, and stored at −80°C prior to utilisation. Control left ventricular tissues were collected...

View article titled, Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo

Includes: Supplementary data

Articles

Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure

Craig A. Lygate

Clin Sci (Lond) (2024) 138 (8): 491–514.

https://doi.org/10.1042/CS20230616

Published: 19 April 2024

... and reperfusion, which represents an acute crisis of energy provision. Evidence is presented from preclinical models that augmentation of the CK system can reduce ischaemia–reperfusion injury and improve functional recovery. Energetic impairment is also a hallmark of chronic heart failure, in particular, down...

View article titled, Maintaining energy provision in the heart: the creatine kinase system in ischaemia–reperfusion injury and chronic heart failure

Articles

The immunology of heart failure with preserved ejection fraction

Charles Duncan Smart, Meena S. Madhur

Clin Sci (Lond) (2023) 137 (16): 1225–1247.

https://doi.org/10.1042/CS20230226

Published: 22 August 2023

...Charles Duncan Smart; Meena S. Madhur Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of new heart failure diagnoses and continues to increase in prevalence in the United States. Importantly, HFpEF is a highly morbid, heterogeneous syndrome lacking effective...

View article titled, The immunology of heart failure with preserved ejection fraction

Articles

Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training

Hiviny de Ataides Raquel, Sany M. Pérego, Gustavo S. Masson, Leonardo Jensen, Alison Colquhoun, Lisete C. Michelini

Clin Sci (Lond) (2023) 137 (15): 1049–1066.

https://doi.org/10.1042/CS20230489

Published: 02 August 2023

...Hiviny de Ataides Raquel; Sany M. Pérego; Gustavo S. Masson; Leonardo Jensen; Alison Colquhoun; Lisete C. Michelini Heart failure (HF) is characterized by reduced ventricular function, compensatory activation of neurohormonal mechanisms and marked autonomic imbalance. Exercise training (T...

View article titled, Blood–brain barrier lesion – a novel determinant of autonomic imbalance in heart failure and the effects of exercise training

Articles

Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Patrizia Dardi, Laís Rossi Perazza, Gisele Kruger Couto, Gianne Paul Campos, Luciano dos Santos Aggum Capettini, Luciana Venturini Rossoni

Clin Sci (Lond) (2021) 135 (23): 2625–2641.

https://doi.org/10.1042/CS20210810

Published: 08 December 2021

...Patrizia Dardi; Laís Rossi Perazza; Gisele Kruger Couto; Gianne Paul Campos; Luciano dos Santos Aggum Capettini; Luciana Venturini Rossoni Arterial endothelial dysfunction has been extensively studied in heart failure (HF). However, little is known about the adjustments shown by the venous system...

View article titled, Vena cava presents endothelial dysfunction prior to thoracic aorta in heart failure: the pivotal role of nNOS uncoupling/oxidative stress

Includes: Supplementary data

Articles

Obesity-associated cardiovascular risk in women: hypertension and heart failure

Jessica L. Faulkner

Clin Sci (Lond) (2021) 135 (12): 1523–1544.

https://doi.org/10.1042/CS20210384

Published: 23 June 2021

..., heart failure with preserved ejection fraction (HFpEF). In addition, emerging evidence indicates that obesity increases the risk of both hypertension and heart failure in pregnancy. This review will summarize clinical and experimental data on the female-specific prevalence and mechanisms of hypertension...

View article titled, Obesity-associated cardiovascular risk in women: hypertension and heart failure

Articles

Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

In Collection

Cardiovascular-Oncology

Leanne Mooney, Carl S. Goodyear, Tamir Chandra, Kristina Kirschner, Mhairi Copland, Mark C. Petrie, Ninian N. Lang

Clin Sci (Lond) (2021) 135 (7): 991–1007.

https://doi.org/10.1042/CS20200306

Published: 16 April 2021

... CHIP, inflammation and atherosclerotic disease has recently become better defined. However, there is a paucity of information about the role of CHIP in the development and progression of heart failure, particularly heart failure with preserved ejection fraction (HFpEF). While systemic inflammation...

View article titled, Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

Articles

Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors

In Collection

Cardiovascular-Oncology

Alan H. Baik, Katy K. Tsai, David Y. Oh, Mandar A. Aras

Clin Sci (Lond) (2021) 135 (5): 703–724.

https://doi.org/10.1042/CS20200331

Published: 09 March 2021

... heart failure immunomodulation Correspondence: Mandar A. Aras ( [email protected] ) 28 12 2020 22 02 2021 24 02 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Given that ICIs use will only become...

View article titled, Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors

Articles

Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Carlos M. Ferrario

Clin Sci (Lond) (2021) 135 (5): 683–686.

https://doi.org/10.1042/CS20210017

Published: 02 March 2021

...Carlos M. Ferrario We comment on the publication of a paper in which Brazilian investigators evaluate the anticontractile response of perivascular adipose tissue (PVAT) in experimental heart failure (HF) induced in rats by occlusion of a coronary artery. Correspondence: Carlos M. Ferrario...

View article titled, Commentary on: Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Articles

Cardiotoxic effects of angiogenesis inhibitors

In Collection

Cardiovascular-Oncology

Stephen J.H. Dobbin, Mark C. Petrie, Rachel C. Myles, Rhian M. Touyz, Ninian N. Lang

Clin Sci (Lond) (2021) 135 (1): 71–100.

https://doi.org/10.1042/CS20200305

Published: 06 January 2021

... systolic dysfunction (LVSD) and heart failure as well as arterial and venous thromboembolism, QTc interval prolongation and arrhythmia. The mechanisms behind the development of VEGFI-associated LVSD and heart failure likely involve the combination of a number of myocardial insults. These include direct...

View article titled, Cardiotoxic effects of angiogenesis inhibitors

Articles

Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

In Collection

ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19

Ravindra K. Sharma, Jing Li, Suraj Krishnan, Elaine M. Richards, Mohan K. Raizada, Rajesh Mohandas

Clin Sci (Lond) (2021) 135 (1): 1–17.

https://doi.org/10.1042/CS20200482

Published: 05 January 2021

... and a receptor for SARS-CoV-2 as well as the implications for Coronavirus disease 19 and its associated cardiovascular and renal complications. Correspondence: Mohan K. Raizada ( [email protected] ) or Rajesh Mohandas ( [email protected] ) ACE2 COVID-19 Heart Failure Hypertension...

View article titled, Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases

Articles

Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Milene Tavares Fontes, Suliana Mesquita Paula, Caroline Antunes Lino, Nathalia Senger, Gisele Kruger Couto, Maria Luiza de Morais Barreto-Chaves, José Geraldo Mill, Luciana Venturini Rossoni

Clin Sci (Lond) (2020) 134 (23): 3195–3211.

https://doi.org/10.1042/CS20201099

Published: 09 December 2020

... diseases. Although heart failure (HF)-induced endothelial dysfunction is associated with renin–angiotensin system (RAS) activation, no data have correlated this syndrome with PVAT dysfunction. Thus, the aim of the present study was to investigate whether the hyperactivation of the RAS in PVAT participates...

View article titled, Renin–angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure

Includes: Supplementary data

Articles

Have a heart: failure to increase GLP-1 caused by heart failure increases the risk of diabetes

Michael J. Ryan

Clin Sci (Lond) (2020) 134 (23): 3119–3121.

https://doi.org/10.1042/CS20201029

Published: 03 December 2020

... ) The potential for renoprotection with incretin-based drugs . Kidney Int. 86 , 701 – 711 10.1038/ki.2014.236 25007170 10. Tenenbaum A. , Motro M. , Fisman E.Z. , Leor J. , Freimark D. , Boyko V. et al . ( 2003 ) Functional class in patients with heart failure...

View article titled, Have a heart: failure to increase GLP-1 caused by heart failure increases the risk of diabetes

Articles

Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure

Beverly Giam, Haru Nomura, Sanjaya Kuruppu, Po-Yin Chu, Sumia Essid, Helen Kiriazis, Xiao-Jun Du, David M. Kaye, Niwanthi W. Rajapakse

Clin Sci (Lond) (2020) 134 (20): 2755–2769.

https://doi.org/10.1042/CS20200087

Published: 30 October 2020

...Beverly Giam; Haru Nomura; Sanjaya Kuruppu; Po-Yin Chu; Sumia Essid; Helen Kiriazis; Xiao-Jun Du; David M. Kaye; Niwanthi W. Rajapakse Heart failure (HF) is associated with impaired L-arginine transport. In the present study, we tested the hypothesis that augmented L-arginine transport prevents...

View article titled, Endothelial-specific overexpression of cationic amino acid transporter-1 prevents loss of kidney function in heart failure

Articles

Cardiovascular toxicity of PI3Kα inhibitors

In Collection

Cardiovascular-Oncology

Chandu Sadasivan, Pavel Zhabyeyev, Dina Labib, James A. White, D. Ian Paterson, Gavin Y. Oudit

Clin Sci (Lond) (2020) 134 (19): 2595–2622.

https://doi.org/10.1042/CS20200302

Published: 14 October 2020

... inhibition in the progression of cancer-related cachexia and female sex and pre-existing comorbidities as independent risk factors for cardiac abnormalities after cancer treatment. cardiac arrhythmia cardio-oncology cardiotoxicity chemotherapy heart failure PI3Kα The phosphoinositide 3...

View article titled, Cardiovascular toxicity of PI3Kα inhibitors

Articles

Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease

Andrew Geissler, Sergey Ryzhov, Douglas B. Sawyer

Clin Sci (Lond) (2020) 134 (19): 2623–2643.

https://doi.org/10.1042/CS20200230

Published: 14 October 2020

... in humans with systolic heart failure. NRG-4 has recently emerged as an adipokine with similar potential to regulate cardiovascular responses to inflammation and injury. Beyond systolic heart failure, NRGs appear to have beneficial effects in diastolic heart failure, prevention of atherosclerosis...

View article titled, Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease

Articles

Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure

Daniel F. Arruda-Junior, Flavia L. Martins, Thiago Almeida Salles, Leonardo Jensen, Rafael Dariolli, Ednei L. Antonio, Leonardo dos Santos, Renato O. Crajoinas, Paulo J.F. Tucci, Luís Henrique W. Gowdak, José Eduardo Krieger, Alexandre C. Pereira, Adriana C. Girardi

Clin Sci (Lond) (2020) 134 (9): 1081–1094.

https://doi.org/10.1042/CS20190946

Published: 07 May 2020

... disturbances in glucose homeostasis and heart failure (HF) progression is bidirectional. However, the mechanisms by which HF intrinsically impairs glucose homeostasis remain unknown. The present study tested the hypothesis that the bioavailability of intact glucagon-like peptide-1 (GLP-1) is affected in HF...

View article titled, Postprandial increase in glucagon-like peptide-1 is blunted in severe heart failure

Includes: Supplementary data

Articles

Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease

In Collection

Adipose biology, cardiovascular and cardiometabolic disease

Rim Rafeh, Anissa Viveiros, Gavin Y. Oudit, Ahmed F. El-Yazbi

Clin Sci (Lond) (2020) 134 (7): 827–851.

https://doi.org/10.1042/CS20190227

Published: 09 April 2020

... are at a high risk of cardiovascular complications ranging from microvascular dysfunction to cardiometabolic syndromes including heart failure. Despite significant advances in the standards of care for obese and diabetic patients, current therapeutic approaches are not always successful in averting...

View article titled, Targeting perivascular and epicardial adipose tissue inflammation: therapeutic opportunities for cardiovascular disease

Articles

Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Jan Neckář, Md. Abdul Hye Khan, Garrett J. Gross, Michaela Cyprová, Jaroslav Hrdlička, Alena Kvasilová, John R. Falck, William B. Campbell, Lenka Sedláková, Šárka Škutová, Veronika Olejníčková, Martina Gregorovičová, David Sedmera, František Kolář, John D. Imig

Clin Sci (Lond) (2019) 133 (8): 939–951.

https://doi.org/10.1042/CS20180728

Published: 29 April 2019

...) and their synthetic analogs have cardiovascular protective effects. Here, we investigated the action of a novel EET analog EET-B on the progression of post-myocardial infarction (MI) heart failure in spontaneously hypertensive rats (SHR). Adult male SHR were divided into vehicle- and EET-B (10 mg/kg/day; p.o., 9...

View article titled, Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats

Articles

Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure

David C. Andrade, Camilo Toledo, Hugo S. Díaz, Claudia Lucero, Alexis Arce-Álvarez, Luiz M. Oliveira, Ana C. Takakura, Thiago S. Moreira, Harold D. Schultz, Noah J. Marcus, Julio Alcayaga, Rodrigo Del Rio

Clin Sci (Lond) (2019) 133 (3): 393–405.

https://doi.org/10.1042/CS20180589

Published: 05 February 2019

...David C. Andrade; Camilo Toledo; Hugo S. Díaz; Claudia Lucero; Alexis Arce-Álvarez; Luiz M. Oliveira; Ana C. Takakura; Thiago S. Moreira; Harold D. Schultz; Noah J. Marcus; Julio Alcayaga; Rodrigo Del Rio Activation of the sympathetic nervous system is a hallmark of heart failure (HF...

View article titled, Ablation of brainstem C1 neurons improves cardiac function in volume overload heart failure

Includes: Supplementary data

Articles

Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

Bianca C. Bernardo, Kate L. Weeks, Thawin Pongsukwechkul, Xiaoming Gao, Helen Kiriazis, Nelly Cemerlang, Esther J.H. Boey, Yow Keat Tham, Chad J. Johnson, Hongwei Qian, Xiao-Jun Du, Paul Gregorevic, Julie R. McMullen

Clin Sci (Lond) (2018) 132 (3): 381–397.

https://doi.org/10.1042/CS20171269

Published: 08 February 2018

... regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase (PI3K(p110α)). Disturbances in cardiac metabolism are a feature of heart failure (HF) patients and targeting metabolic defects is considered a potential therapeutic approach...

View article titled, Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling

Includes: Supplementary data

Articles

Gut microbiota in cardiovascular disease and heart failure

Takeshi Kitai, W.H. Wilson Tang

Clin Sci (Lond) (2018) 132 (1): 85–91.

https://doi.org/10.1042/CS20171090

Published: 11 January 2018

... metabolites, and the development and progression of hypertension, heart failure, and chronic kidney disease. 02 09 2017 15 11 2017 20 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease chronic kidney...

View article titled, Gut microbiota in cardiovascular disease and heart failure

Articles

Mechanisms contributing to cardiac remodelling

Qing-Qing Wu, Yang Xiao, Yuan Yuan, Zhen-Guo Ma, Hai-Han Liao, Chen Liu, Jin-Xiu Zhu, Zheng Yang, Wei Deng, Qi-zhu Tang

Clin Sci (Lond) (2017) 131 (18): 2319–2345.

https://doi.org/10.1042/CS20171167

Published: 25 August 2017

... in the left ventricle (LV) in response to internal or external cardiovascular damage or influence by pathogenic risk factors, and is a precursor of clinical heart failure (HF). Pathological remodelling is associated with fibrosis, inflammation and cellular dysfunction (e.g. abnormal cardiomyocyte/non...

View article titled, Mechanisms contributing to cardiac remodelling

Articles

Mitochondrial Sirtuins in cardiometabolic diseases

Xiaoqiang Tang, Xiao-Feng Chen, Hou-Zao Chen, De-Pei Liu

Clin Sci (Lond) (2017) 131 (16): 2063–2078.

https://doi.org/10.1042/CS20160685

Published: 24 July 2017

... Society 2017 Cardiometabolic diseases cardiovascular physiology heart failure mitochondria pulmonary hypertension sirtuins Cardiometabolic disease (CMD) or cardiometabolic syndrome, remains one of the leading causes of morbidity and mortality worldwide. CMD is a disease entity...

View article titled, Mitochondrial Sirtuins in cardiometabolic diseases

Articles

The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Matthew Kerr, Michael S. Dodd, Lisa C. Heather

Clin Sci (Lond) (2017) 131 (16): 2079–2094.

https://doi.org/10.1042/CS20160671

Published: 24 July 2017

... concomitantly with changes in cardiac function. In heart failure, FA oxidation is decreased, correlating with systolic dysfunction and hypertrophy. In contrast, in type 2 diabetes, FA oxidation and triglyceride storage are increased, and correlate with diastolic dysfunction and insulin resistance. Therefore...

View article titled, The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right

Articles

Molecular mechanisms in cardiomyopathy

Keith Dadson, Ludger Hauck, Filio Billia

Clin Sci (Lond) (2017) 131 (13): 1375–1392.

https://doi.org/10.1042/CS20160170

Published: 23 June 2017

... Ca 2+ release channel inactivation, impaired cardiac contractility with the development of heart failure [ 42 ]. Similarly, mutations in JPH2 were found in 0.8% of unrelated patients diagnosed with HCM [ 43 ]. Correspondence: Filio Billia ( [email protected] ) 5 9 2016 15 2...

View article titled, Molecular mechanisms in cardiomyopathy

Articles

Discrepant effects of heart failure on electrophysiological property in right ventricular outflow tract and left ventricular outflow tract cardiomyocytes

Yen-Yu Lu, Chen-Chuan Cheng, Chin-Feng Tsai, Yung-Kuo Lin, Ting-I Lee, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen

Clin Sci (Lond) (2017) 131 (12): 1317–1327.

https://doi.org/10.1042/CS20170121

Published: 07 June 2017

...Yen-Yu Lu; Chen-Chuan Cheng; Chin-Feng Tsai; Yung-Kuo Lin; Ting-I Lee; Yao-Chang Chen; Shih-Ann Chen; Yi-Jen Chen Ventricular arrhythmias commonly arise from the right (RVOT) and left ventricular outflow tracts (LVOT) in patients without structural heart disease. Heart failure (HF) significantly...

View article titled, Discrepant effects of heart failure on electrophysiological property in right ventricular outflow tract and left ventricular outflow tract cardiomyocytes

Articles

Advances in heart failure: a review of biomarkers, emerging pharmacological therapies, durable mechanical support and telemonitoring

Yasbanoo Moayedi, Heather J. Ross

Clin Sci (Lond) (2017) 131 (7): 553–566.

https://doi.org/10.1042/CS20160196

Published: 17 March 2017

...Yasbanoo Moayedi; Heather J. Ross The purpose of this review is to provide an overview of diagnosis, prognosis and management of heart failure (HF) with reduced ejection fraction (HFrEF). Specifically, this review is divided into three sections. The first section will address biomarkers...

View article titled, Advances in heart failure: a review of biomarkers, emerging pharmacological therapies, durable mechanical support and telemonitoring

Articles

Perspective on precision medicine in paediatric heart failure

Michael D. Fridman, Seema Mital

Clin Sci (Lond) (2017) 131 (6): 439–448.

https://doi.org/10.1042/CS20160414

Published: 06 March 2017

...Michael D. Fridman; Seema Mital In 2015, President Obama launched the Precision Medicine Initiative (PMI), which introduced new funding to a method of research with the potential to study rare and complex diseases. Paediatric heart failure, a heterogeneous syndrome affecting approximately 1...

View article titled, Perspective on precision medicine in paediatric heart failure

Articles

Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy

Natalie J. Galant, Per Westermark, Jeffrey N. Higaki, Avijit Chakrabartty

Clin Sci (Lond) (2017) 131 (5): 395–409.

https://doi.org/10.1042/CS20160413

Published: 17 February 2017

... diagnostic accuracy, available and newly developing therapeutics, as well as a brief biochemical and biophysical background of TTR amyloidogenesis. ATTR amyloidosis cardiac amyloidosis cardiomyopathy heart failure polyneuropathy transthyretin amyloidosis There is a growing awareness...

View article titled, Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy

Articles

An emerging epidemic: cancer and heart failure

Paaladinesh Thavendiranathan, Mark T. Nolan

Clin Sci (Lond) (2017) 131 (2): 113–121.

https://doi.org/10.1042/CS20160412

Published: 14 December 2016

...Paaladinesh Thavendiranathan; Mark T. Nolan Heart disease and cancer are the two leading causes of mortality globally. Cardiovascular complications of cancer therapy significantly contribute to the global burden of cardiovascular disease. Heart failure (HF) in particular is a relatively common...

View article titled, An emerging epidemic: cancer and heart failure

Articles

Pathophysiology of exercise intolerance in breast cancer survivors with preserved left ventricular ejection fraction

Mark J. Haykowsky, Rhys Beaudry, R. Matthew Brothers, Michael D. Nelson, Satyam Sarma, Andre La Gerche

Clin Sci (Lond) (2016) 130 (24): 2239–2244.

https://doi.org/10.1042/CS20160479

Published: 04 November 2016

...Mark J. Haykowsky; Rhys Beaudry; R. Matthew Brothers; Michael D. Nelson; Satyam Sarma; Andre La Gerche Breast cancer (BC) survival rates have improved during the past two decades and as a result older BC survivors are at increased risk of developing heart failure (HF). Although the HF phenotype...

View article titled, Pathophysiology of exercise intolerance in breast cancer survivors with preserved left ventricular ejection fraction

Articles

Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients

Idoia Gallego, Javier Beaumont, Begoña López, Susana Ravassa, Juan José Gómez-Doblas, María Ujué Moreno, Félix Valencia, Eduardo de Teresa, Javier Díez, Arantxa González

Clin Sci (Lond) (2016) 130 (23): 2139–2149.

https://doi.org/10.1042/CS20160462

Published: 20 October 2016

... patients presented lower cardiomyocyte density ( P <0.001) and ejection fraction ( P <0.05), and higher troponin T levels ( P <0.05), prevalence of heart failure (HF; P <0.05) and NT-proBNP levels ( P <0.05) than those from group 1. miRNA expression profile analysed in 5 patients randomly...

View article titled, Potential role of microRNA-10b down-regulation in cardiomyocyte apoptosis in aortic stenosis patients

Includes: Supplementary data

Articles

Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity

Shino Oikawa, Yuko Kai, Masayuki Tsuda, Hisayuki Ohata, Asuka Mano, Naoko Mizoguchi, Shuei Sugama, Takahiro Nemoto, Kenji Suzuki, Atsushi Kurabayashi, Kazuyo Muramoto, Makoto Kaneda, Yoshihiko Kakinuma

Clin Sci (Lond) (2016) 130 (21): 1913–1928.

https://doi.org/10.1042/CS20160277

Published: 22 September 2016

... stimulation (VS), and consequently re-educate the central nervous system (CNS) to reset stress responses. acetylcholine autonomic nervous system heart failure stress vagus nerve As previously reported, ChAT tgm on a C57BL6/J genetic background were developed to overexpress the ChAT gene...

View article titled, Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity

Articles

Women and heart disease, the underrecognized burden: sex differences, biases, and unmet clinical and research challenges

Stacy Westerman, Nanette K. Wenger

Clin Sci (Lond) (2016) 130 (8): 551–563.

https://doi.org/10.1042/CS20150586

Published: 08 March 2016

.... These differences can be found in all domains of cardiovascular health and disease, including heart rhythm, heart failure, coronary disease and valvular disease. Further understanding of gender differences in the heart is crucial for advancing our ability to maintain a healthy population and identify and treat...

View article titled, Women and heart disease, the underrecognized burden: sex differences, biases, and unmet clinical and research challenges

Articles

Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases

Raffaele Altara, Marco Manca, Rita D. Brandão, Asad Zeidan, George W. Booz, Fouad A. Zouein

Clin Sci (Lond) (2016) 130 (7): 463–478.

https://doi.org/10.1042/CS20150666

Published: 17 February 2016

... has revealed the participation of CXCR3 and its ligands in multiple cardiovascular diseases (CVDs) of different aetiologies including atherosclerosis, hypertension, cardiac hypertrophy and heart failure, as well as in heart transplant rejection and transplant coronary artery disease (CAD). CXCR3...

View article titled, Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases

Articles

The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment

Massimo Volpe, Marino Carnovali, Vittoria Mastromarino

Clin Sci (Lond) (2016) 130 (2): 57–77.

https://doi.org/10.1042/CS20150469

Published: 04 December 2015

...Massimo Volpe; Marino Carnovali; Vittoria Mastromarino After its discovery in the early 1980s, the natriuretic peptide (NP) system has been extensively characterized and its potential influence in the development and progression of heart failure (HF) has been investigated. HF is a syndrome...

View article titled, The natriuretic peptides system in the pathophysiology of heart failure: from molecular basis to treatment

Articles

Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy

Yee Kwan Chan, Hye Kyoung Sung, Gary Sweeney

Clin Sci (Lond) (2015) 129 (10): 851–862.

https://doi.org/10.1042/CS20150075

Published: 28 August 2015

... states, and in particular has recently become regarded as one of the best diagnostic biomarkers available for acute kidney injury. Nevertheless, the precise physiological effects of NGAL on the heart and the significance of their alterations during the development of heart failure are only now beginning...

View article titled, Iron metabolism and regulation by neutrophil gelatinase-associated lipocalin in cardiomyopathy

Articles

Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents

Liang Shen, Ci Chen, Xuan Wei, Xixian Li, Guangjin Luo, Jingwen Zhang, Jianping Bin, Xiaobo Huang, Shiping Cao, Guofeng Li, Yulin Liao

Clin Sci (Lond) (2015) 128 (10): 665–678.

https://doi.org/10.1042/CS20140586

Published: 20 February 2015

...Liang Shen; Ci Chen; Xuan Wei; Xixian Li; Guangjin Luo; Jingwen Zhang; Jianping Bin; Xiaobo Huang; Shiping Cao; Guofeng Li; Yulin Liao The Ankrd1 (ankyrin repeat domain 1) gene is known to be up-regulated in heart failure and acts as a co-activator of p53, modulating its transcriptional activity...

View article titled, Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents

Includes: Supplementary data

Articles

Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure

Tzu-Pin Weng, Tieh-Cheng Fu, Chao-Hung Wang, Chih-Chin Hsu, Jong-Shyan Wang

Clin Sci (Lond) (2014) 127 (10): 589–602.

https://doi.org/10.1042/CS20130789

Published: 18 July 2014

...Tzu-Pin Weng; Tieh-Cheng Fu; Chao-Hung Wang; Chih-Chin Hsu; Jong-Shyan Wang Lymphocytopenia is associated with an adverse prognosis in heart failure (HF). The present study investigated whether lymphocytopenia results from activated lymphocyte autophagy/apoptosis, which reflects haemodynamic...

View article titled, Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure

Articles

Loss of NOX2 (gp91 phox ) prevents oxidative stress and progression to advanced heart failure

Nirmal Parajuli, Vaibhav B. Patel, Wang Wang, Ratnadeep Basu, Gavin Y. Oudit

Clin Sci (Lond) (2014) 127 (5): 331–340.

https://doi.org/10.1042/CS20130787

Published: 15 May 2014

...Nirmal Parajuli; Vaibhav B. Patel; Wang Wang; Ratnadeep Basu; Gavin Y. Oudit Oxidative stress plays a key pathogenic role in experimental and human heart failure. However, the source of ROS (reactive oxygen species) is a key determinant of the cardiac adaptation to pathological stressors...

View article titled, Loss of NOX2 (gp91 phox ) prevents oxidative stress and progression to advanced heart failure

Articles

Lung capillary injury and repair in left heart disease: a new target for therapy?

Sayena Azarbar, Jocelyn Dupuis

Clin Sci (Lond) (2014) 127 (2): 65–76.

https://doi.org/10.1042/CS20130296

Published: 17 March 2014

... exchange. This pathological process may also contribute to PH (pulmonary hypertension) due to LHD. Few clinical trials have specifically evaluated lung structural remodelling and the effect of related therapies in LHD. Currently approved treatment for chronic HF (heart failure) may have direct beneficial...

View article titled, Lung capillary injury and repair in left heart disease: a new target for therapy?

Articles

Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases

Speranza Rubattu, Sebastiano Sciarretta, Massimo Volpe

Clin Sci (Lond) (2014) 127 (1): 1–13.

https://doi.org/10.1042/CS20130427

Published: 10 March 2014

... peptide cardiac hypertrophy gene variant heart failure NT-proANP levels hypertension metabolic syndrome vascular damage In this regard, we have learned a lot from experimental animals and molecular genetic searches. Overexpression of NPPA via gene therapy in hypertensive mice lowered...

View article titled, Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases

Articles

The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

Irving H. Zucker, Liang Xiao, Karla K. V. Haack

Clin Sci (Lond) (2014) 126 (10): 695–706.

https://doi.org/10.1042/CS20130294

Published: 27 January 2014

...Irving H. Zucker; Liang Xiao; Karla K. V. Haack CHF (chronic heart failure) is a multifactorial disease process that is characterized by overactivation of the RAAS (renin–angiotensin–aldosterone system) and the sympathetic nervous system. Both of these systems are chronically activated in CHF...

View article titled, The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure

Articles

Potential of cardiac stem/progenitor cells and induced pluripotent stem cells for cardiac repair in ischaemic heart disease

Wei Eric Wang, Xiongwen Chen, Steven R. Houser, Chunyu Zeng

Clin Sci (Lond) (2013) 125 (7): 319–327.

https://doi.org/10.1042/CS20130019

Published: 07 June 2013

... that CS/PC therapy reduced it by 25–38% (percentage of control). Three clinical trials have been conducted to test the therapeutic efficacy of CS/PCs for heart failure resulting from ischaemic heart disease, including SCIPIO (ClinicalTrials.gov Identifier NCT00474461) [ 10 ], CADUCEUS (CArdiosphere...

View article titled, Potential of cardiac stem/progenitor cells and induced pluripotent stem cells for cardiac repair in ischaemic heart disease

Articles

Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer

Clin Sci (Lond) (2013) 124 (6): 391–401.

https://doi.org/10.1042/CS20120334

Published: 27 November 2012

... gene transcript heart failure sepsis • Myocardial function is depressed in sepsis and is an important prognosticator in patients. • Using a long-term fluid-resuscitated rat model of faecal peritonitis, we demonstrate that significant differences in stroke volume and HR measured 6 h...

View article titled, Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Includes: Supplementary data

Articles

Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure

Mingya Liu, Mi Zhou, Yuqian Bao, Zhiyong Xu, Huating Li, Hao Zhang, Wei Zhu, Jialiang Zhang, Aimin Xu, Meng Wei, Weiping Jia

Clin Sci (Lond) (2013) 124 (2): 115–122.

https://doi.org/10.1042/CS20120004

Published: 26 September 2012

... and atherosclerosis in animals. In the present study, we sought to investigate the association of A-FABP with HF (heart failure) in Chinese subjects. Serum A-FABP levels were measured in 252 HF patients and 261 age-, gender- and BMI (body mass index)-matched non-HF subjects. Echocardiography was performed on each...

View article titled, Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure

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