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Keywords: heat-shock transcription factor 1
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Articles
Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (6): 477–487.
Published: 22 June 2015
... (reactive oxygen species) formation and SIRT1 (sirtuin 1) degradation through a proteasome-dependent mechanism, thereby mitigating the activity of SIRT1 by deacetylating HSF1 (heat-shock transcription factor 1). We also found that NOX2 is a key NAPDH oxidase isoform responsible for the Hcy-caused ROS...
