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Keywords: heme oxygenase 1
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Articles
Heme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat
Available to PurchasePamela L. Martín, Paula Ceccatto, María V. Razori, Daniel E.A. Francés, Sandra M.M. Arriaga, Gerardo B. Pisani, Alejandra I. Martínez, Enrique J. Sánchez Pozzi, Marcelo G. Roma, Cecilia L. Basiglio
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (1): 117–134.
Published: 11 January 2019
... of unconjugated bilirubin (BR) prevent oxidative stress (OS)-induced hepatocanalicular dysfunction and cholestasis. Here, we aimed to ascertain, in the whole rat, whether a similar cholestatic OS injury can be counteracted by heme oxygenase-1 (HO-1) induction that consequently elevates endogenous BR levels...
Includes: Supplementary data
Articles
TLR2 and TLR4 play opposite role in autophagy associated with cisplatin-induced acute kidney injury
Available to PurchaseMagaiver Andrade-Silva, Marcos Antonio Cenedeze, Luiz Augusto Perandini, Raphael José Ferreira Felizardo, Ingrid Kazue Mizuno Watanabe, Juan Sebastian Henao Agudelo, Angela Castoldi, Giselle Martins Gonçalves, Clarice Silvia Taemi Origassa, Patricia Semedo, Meire Ioshie Hiyane, Orestes Foresto-Neto, Denise Maria Avancini Costa Malheiros, Marlene Antonia Reis, Clarice Kazue Fujihara, Roberto Zatz, Alvaro Pacheco-Silva, Niels Olsen Saraiva Câmara, Danilo Candido de Almeida
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (16): 1725–1739.
Published: 22 August 2018
... the specific participation of TLR2 and TLR4 molecules on the development of cisplatin-induced AKI. Complementarily, we also investigated the link between TLRs and heme oxygenase-1 (HO-1), a promisor cytoprotective molecule. First, we observed that only the absence of TLR2 but not TLR4 in mice exacerbated...
Includes: Supplementary data
