...Anne-Christine Piguet; Syamantak Majumder; Uma Maheshwari; Reji Manjunathan; Uttara Saran; Suvro Chatterjee; Jean-François Dufour Progression of liver fibrosis to HCC (hepatocellular carcinoma) is a very complex process which involves several pathological phenomena, including hepatic stellate cell...

...Alain Da Silva Morais; Jorge Abarca-Quinones; Bruno Guigas; Benoit Viollet; Peter Stärkel; Yves Horsmans; Isabelle A. Leclercq Inhibition or blockade of HSCs (hepatic stellate cells), the main matrix-producing cells involved in the wound-healing response, represents an attractive strategy...

... cirrhosis collagen fibrosis hepatic stellate cell inflammation liver myofibroblast Fibrosis of the liver and its end stage, cirrhosis, represents a massive health care burden worldwide. Liver disease is increasing in incidence globally. In the West, the main causes of liver fibrosis...

...C. A. KAWSER; J. P. IREDALE; P. J. WINWOOD; M. J. P. ARTHUR 1. Hepatic stellate cells are key mediators of hepatic fibrosis. We have studied hepatic stellate cell expression of the collagenase and general protease inhibitor α2-macroglobulin after activation in tissue culture and in response...