... during chronic liver injury and directly promotes fibrosis. We have reported that Hh signalling enhances viral permissiveness and replication in HCV (hepatitis C virus)-infected cells. Hence we hypothesized that OPN directly promotes HCV replication, and that targeting OPN could be beneficial in HCV...

... steatohepatitis, fibrogenesis, and chronic HBV (hepatitis B virus) and HCV (hepatitis C virus) infection. Hepatitis viruses have developed different evading strategies to subvert the innate immune system. Thus recent studies have suggested that TLR-based therapies may represent a promising approach...

...J. Berlanga; M. E. Caballero; D. Ramirez; A. Torres; C. Valenzuela; J. Lodos; R. J. Playford 1. Epidermal growth factor (EGF) is known to protect the gastrointestinal tract against various noxious agents. Its potential value in preventing/treating hepatic injury is, however, largely unexplored. We...

..., such as hepatocellular carcinoma or liver cirrhosis caused by chronic viral hepatitis, and correlated with reduced albumin levels in these conditions, indicating that the liver is the site of phosphoinositol-specific phospholipase D synthesis and that phosphoinositol-specific phospholipase D may be used as an additional...

... the subjects with the normal ADH form, hepatic ADH activity was unaltered in subjects with non-alcoholic liver disease (chronic hepatitis or cirrhosis) and in those with alcoholic steatosis. Subjects with alcoholic hepatitis or alcoholic cirrhosis showed a lower ADH activity compared with the healthy control...

... adaptation hepatitis zinc Clinical Science (1982) 62,109-1 11 109 Zinc deficiency and photoreceptor dysfunction in chronic liver disease P. W. N . K E E L I N G , J . O DAY*, W. R U S E A N D R. P. H . T H O M P S O N Gastrointestinal Laboratory. The Rayne Institute, and Department of Ophthalmology, St...

...P. W. N. Keeling; W. Ruse; J. Bull; B. Hannigan; R. P. H. Thompson 1. 65 Zn was injected intravenously during transjugular liver biopsy and, from simultaneous hepatic and peripheral venous blood samples, hepatointestinal 65 Zn extraction was calculated. Hepatic zinc content was measured in biopsy...

...Cameron G. Strong; Hugo R. Tapia; James C. Hunt 1. Hepatic metabolism of renin activity was studied in seven normal dogs, twelve dogs with acute hepatic allograft rejection, five dogs with chronic toxic hepatitis and in seven isolated canine liver preparations. 2. Renin activity was measured...