... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Bile acids Cyp2c70 Gut microbiota Hepatobiliary disease Hydrophobicity UDCA Mice are commonly used as experimental models to mimic and study human pathologies. However, when investigating...

... of AB administration to cholestatic patients should be evaluated in a systematic manner. bile acids Cyp2c70 gut microbiota hepatobiliary disease hydrophobicity liver fibrosis Correspondence: Jan Freark de Boer ( [email protected] ) or Folkert Kuipers ( [email protected]...

...-dependent signs of hepatobiliary disease and can be used as a model to study interactions between bile acids and the gut microbiota in cholestatic liver disease. In the present study, we rederived Cyp2c70 −/− mice as germ-free (GF) and colonized them with a human or a mouse microbiota to investigate whether...