... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 Correspondence: Wei Dong ( [email protected] ) or Anding Liu ( [email protected] ) 30 04 2019 20 09 2019 09 10 2019 cell cycle arrest GDF11 hepatocyte liver regeneration...

... by targeting extracellular signal-regulated kinase 1 (ERK1) signalling in hepatic stellate cells (HSC) and hepatocyte epithelial–mesenchymal transition (EMT). Our results revealed that enhanced miR-21 levels in cirrhotic patients were related to the severity and activity of liver cirrhosis. Ad-TuD-21...

... factor β) and CCL20 (CC chemokine ligand 20) accompanied the changes in Th17/Th22 cells. Livers of IL-17 −/− mice were protected from NASH development and characterized by an extensive infiltration of Th22 cells. In vitro , IL-17 exacerbated the JNK (c-Jun N-terminal kinase)-dependent mouse hepatocyte...

... with myriocin. Since myriocin is a known inhibitor of ERK (extracellular-signal-related kinase) phosphorylation, we assessed the possibility that myriocin may be acting to increase hepatic apoA-I production via this pathway. To address this, HepG2 cells and primary mouse hepatocytes were treated with 200 μM...

... our understanding of the governance of the concentration of plasma LDL and the maintenance of cholesterol homoeostasis in the hepatocyte. We believe that regulation of cholesterol homoeostasis within the hepatocyte is demonstrably more complex than envisioned by the LDL receptor paradigm...

... populations within the liver may contribute to the development of this autoimmune liver disease and may represent a fruitful area for future investigation. cytokine dendritic cell hepatocyte innate immunity liver disease natural killer T-cell (NKT cell) NKT cells [NK (natural killer) T-cells...

...Marcel C. G. van de Poll; Sebastiaan J. P. Hanssen; Maaike Berbée; Nicolaas E. P. Deutz; Diethard Monbaliu; Wim A. Buurman; Cornelis H. C. Dejong Arginine is an important substrate in health and disease. It is a commonly held view that arginase-1 release from injured erythrocytes and hepatocytes...

... or cholestatic disorders. During liver injury, liver cells are exposed to increased levels of cytokines, bile acids and oxidative stress. This results in death of hepatocytes. In contrast, stellate cells become active and are resistant against cell death. Eventually, acute and chronic liver injury is followed...

...Michele A. MARKLEY; Agostino PIERRO; Simon EATON Glutamine has beneficial effects on enterocytes and the immune system in sepsis, but its effects on hepatic metabolism remain unknown. The aim of the present study was to determine the effects of glutamine on hepatocyte energy metabolism under...

...M.E. MENDOZA; M.J. MONTE; M.Y. EL-MIR; M.D. BADIA; J.J.G. MARIN Bile acids reach the nuclei of hepatocytes, where they may play an important role in controlling gene expression by binding to nuclear receptors. In previous studies, changes in the amounts of the different molecular species of bile...

... individuals would be reproducible in PBMCs isolated from patients with multiple organ failure (acute disease model) and gastrointestinal cancer (chronic disease model). The effects of interleukin-4 on the ability of PBMC supernatants to elicit an acute phase protein response from isolated human hepatocytes...

... 1995 antidiuretic hormone hepatocyte mRNA receptors vasopressin Clinical Science (1995) 88, 671674 (Printed in Great Britain) 67 I Down-regulation of vasopressin Vla receptor mRNA in diabetes mellitus in the rat Paddy A. PHILLIPS, John RISVANIS, Anne-Marie HUTCHINS, Louise M. BURRELL...