... therapeutic value remain largely unknown. In the present study, we investigated the biological roles of CD147 in liver fibrosis and assessed its therapeutic value as a target molecule in the CCl 4 -induced liver fibrosis mouse model. We found that CD147 was highly expressed in both hepatocytes and SECs...

... during graft implantation. Concretely, in the liver, when temperature and cell metabolism ramps up, damage switches from the more cold-sensitive LSEC to the warm ischaemia-sensitive hepatocytes [ 16 ]. In the light of these findings, one might assume that normothermic preservation [using NMP...

... glyoxylate is increased fourfold by the addition of either NAD or NADH. 3. In isolated rat hepatocytes, the 3-hydroxy-1 H -pyrrole-2,5-dione derivatives of glycollate, which are specific inhibitors of glycollate oxidase, have a greater effect on glycollate metabolism than on glyoxylate metabolism. 4...

... , PGF 2α and 16,16-dimethyl-PGE 2 did not stimulate fibrinogen synthesis and fibrinogen polypeptide mRNA content when administered intraperitoneally to rats or when added to monolayer cultures of rat hepatocytes. 3. Cyclo-oxygenase inhibitors did not abolish the stimulation of fibrinogen synthesis...

... decreased from 8.0 ±1.6 to 0.23 ± 0.03 ( P > 0.001). 4. Hepatocytes prepared from control or rT 3 treated rats were incubated with [l- 14 C]oleate and the rates of 14 CO 2 release and glucose production were estimated. Despite the changes in ratio of T 3 to rT 3 observed in vivo , rates of 14 CO 2...

...H. K. Metcalfe; J. P. Monson; S. G. Welch; R. D. Cohen 1. The rate of efflux of ketone bodies has been studied in isolated hepatocytes prepared from starved rats and preloaded with d -3-[ 14 C]hydroxybutyrate. 2. Efflux of ketone bodies was temperature-dependent, saturable and inhibited by α-cyano...

...Rita A. Klim; Marta Albajar; Reginald Hems; Dermot H. Williamson 1. The effects of chronic uraemia on glucose production and nitrogen release (urea plus ammonia formation) from alanine, glutamine or serine in isolated rat hepatocytes were studied. 2. Uraemia increased the rate of formation of urea...

...J. P. Monson; J. A. Smith; R. D. Cohen; R. A. Iles 1. The rate of uptake in 15 s of l - and d -lactate was studied in isolated hepatocyte preparations from starved rats. 2. Observations were also made of the effect of different concentrations of unlabelled l - and d -lactate on l -[ 14 C]- and d...