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High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT 1 receptor activation

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Tamara Sáez, Floor Spaans, Raven Kirschenman, Tatsuya Sawamura, Sandra T. Davidge
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2295–2313.
https://doi.org/10.1042/CS20200764
Published: 04 September 2020
... AT 1 activation, resulting in vascular dysfunction. Pregnant wild-type (WT) and transgenic LOX-1 overexpressing (LOX-1tg) mice were fed a control diet (CD) or high-cholesterol diet (HCD, to impair vascular function) between gestational day (GD) 13.5-GD18.5. On GD18.5, AngII-induced vasoconstriction...
View article titled, High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: potential role for oxidized LDL-induced LOX-1 and AT 1 receptor activation
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Includes: Supplementary data