... active in plasma ex vivo , may impair platelet macroaggregation after in vivo heparinization and during cardiopulmonary bypass. In the present study, proteins were added in vitro to hirudin (200units·ml -1 )-anticoagulated blood from healthy volunteers, and the platelet macroaggregatory responses to ex...

...Valentine C. Menys; Philip R. Belcher; Mark I. M. Noble; George E. Drossos; Ravi Pillai; Steve Westaby 1. We tested the effect of intravenous adrenaline at 0.55–1.10 nmol min −1 kg −1 (for 3–8 min, at 7–10 min post bypass; n = 7) on both microaggregation in hirudinized whole blood, using platelet...

...) hyporeactivity to noradrenaline. In rats infused with lipopolysaccharide and heparin (1 U min −1 kg −1 , 0.4 ml/h) or hirudin (2.2 mg ml −1 kg −1 , 0.8 ml/h), vasopressor responses to noradrenaline were not different from those after infusion of lipopolysaccharide alone. Aortic rings taken from rats receiving...

... (i.e. hirudin and citrate) on platelet aggregation in vitro was compared. 2. Eighty-four patients with stable angina pectoris were studied. Sixteen patients were on acetylsalicylic acid treatment (150-250 mg daily), whereas 68 patients were free from acetylsalicylic acid. Platelet-rich-plasma...