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Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
...Alessandro Pini; Roberta Verta; Cristina Grange; Maura Gurrieri; Arianna Carolina Rosa The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an...
Clin Sci (Lond) (2014) 127 (11): 635–643.
Published: 29 July 2014
... weeks. Tiotropium was co-administered until 5 days before each histamine challenge (the primary outcome). Sixteen patients completed the study [mean age, 38 years; forced expiratory volume in 1 s (FEV 1 ), 86.4%; histamine provocative concentration causing a 20% fall in FEV 1 (PC 20 ), 1.39 mg/ml; ICS...
Clin Sci (Lond) (1998) 95 (5): 611–619.
Published: 01 November 1998
... interacts with other constrictor stimuli. 2. To provide data on this issue, we exposed 17 subjects with asthma to isocapnic hyperventilation of frigid air (HV), methacholine (METH) and histamine (HIS) alone and in combination. 3. With HV (mean ventilation = 55.6±7.7 litres/min), METH (2.20±0.7 ;mmol/l) and...
Clin Sci (Lond) (1997) 93 (4): 363–370.
Published: 01 October 1997
... investigated the levels of mast cell tryptase and histamine and also of eosinophil cationic protein in synovial fluid collected from 31 patients with rheumatoid arthritis, 14 with seronegative spondyloarthritis and nine with osteoarthritis. Two RIAs for tryptase were employed: one with monoclonal antibody AA5...
Clin Sci (Lond) (1997) 93 (3): 279–286.
Published: 01 September 1997
..., eosinophils and antigen-presenting Langerhan's cells. 3. We have conducted a qualitative study of mast cell and basophil histamine release in nine atopic individuals with Ile-181→Leu mutation of FcεRIβ, and ten unrelated similarly atopic individuals without Ile-181→Leu mutation. There were non-significant...
Clin Sci (Lond) (1994) 86 (1): 49–53.
Published: 01 January 1994
...F. J. van Overveld; R. F. De Jongh; P. G. Jorens; P. Walter; L. Bossaert; W. A. De Backer 1. The presence of histamine and tryptase in serum during and after coronary artery bypass grafting may be an indication of the induction of inflammation. 2. One group of patients received no glucocorticoids...
Clin Sci (Lond) (1991) 81 (2): 183–188.
Published: 01 August 1991
...A. F. Walls; A. R. Bennett; R. C. Godfrey; S. T. Holgate; M. K. Church 1. Mast cell activation in the lung was investigated by measuring concentrations of mast cell tryptase and histamine in the bronchoalveolar lavage fluid from patients with bronchial carcinoma, sarcoidosis, extrinsic allergic...
Clin Sci (Lond) (1991) 80 (6): 565–569.
Published: 01 June 1991
... by vasoactive substances, particularly histamine, released from mast cells. 28 11 1990 4 1 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 blood pressure histamine nerve growth factor Clinical Science (1991) 80,565-569 565 Hypotension induced by...
Clin Sci (Lond) (1990) 79 (5): 477–482.
Published: 01 November 1990
...Felix Stockenhuber; Robert W. Kurz; Kaspar Sertl; Georg Grimm; Peter Balcke 1. We determined plasma levels of histamine in uraemic patients and examined their correlation with the presence of pruritus. 2. In 27 patients with chronic renal failure, plasma histamine levels were analysed by...
Clin Sci (Lond) (1990) 79 (4): 325–330.
Published: 01 October 1990
... trachealis. 2. To determine whether such drugs alter bronchial reactivity in vivo , we have studied the effect of oral digoxin (an inhibitor of Na + /K + -adenosine triphosphatase) and oral and inhaled amiloride on bronchial reactivity to histamine in three double-blind, placebo-controlled studies. 3...
Clin Sci (Lond) (1989) 77 (5): 467–471.
Published: 01 November 1989
... study. 3. Vasopressin, given as an infusion at a rate of 2 i.u./h for 1 h, followed by 4 i.u./h for a further hour, produced plasma concentrations of 12.8 and 17 ng/l, respectively, compared with 2.0 and 2.0 ng/l on placebo. 4. Airway reactivity to histamine was measured after 1 and 2 h as the...
Clin Sci (Lond) (1989) 76 (5): 479–485.
Published: 01 May 1989
... studied. 2. The effects of histamine, leukotriene (LT) D 4 and platelet-activating factor (PAF) on microvascular permeability in the nasal mucosa, larynx, trachea, main bronchi and intrapulmonary airways of the guinea pig were assessed by measuring the extravasation of intravenously administered Evans...
Clin Sci (Lond) (1988) 75 (4): 429–436.
Published: 01 October 1988
...G. D. Phillips; S. T. Holgate 1. Adenosine 5′-monophosphate (AMP) causes bronchoconstriction in atopic and non-atopic asthma by a mechanism believed to involve histamine release from airway mast cells. To determine whether preformed mast cell mediators, principally histamine, can initiate a late...
Clin Sci (Lond) (1987) 72 (5): 585–592.
Published: 01 May 1987
... reaction. The effects of LTD 4 were compared with those of histamine and the mechanism of action sought. 2. Thirty-three non-atopic individuals participated in the study. The two drugs were inhaled as an aerosol of small particles causing a relative peripheral deposition pattern in order to mimic the...
Clin Sci (Lond) (1986) 71 (4): 385–392.
Published: 01 October 1986
... asthma. 2. In an initial study on three asthmatic subjects, subconstrictor (subthreshold) concentrations of two mast cell derived mediators, histamine and prostaglandin (PG) D 2 , produced similar displacement to the left of a histamine concentration–specific airways conductance (s G aw) response curve...
Clin Sci (Lond) (1985) 69 (1): 63–69.
Published: 01 July 1985
...D. J. R. Morgan; I. Moodley; D. R. Cundell; B. D. Sheinman; W. Smart; R. J. Davies 1. Plasma histamine and serum neutrophil chemotactic activity (S-NCA) were measured in ten atopic asthmatic patients on four separate occasions after allergen bronchial provocation testing (BPT). 2. Single doses of...
Clin Sci (Lond) (1985) 68 (4): 427–432.
Published: 01 April 1985
... they fail to stain in the alcian blue-safranin reaction after fixation in formol-saline but stain well after fixation in Carnoy's solution. Cells staining with berberine sulphate were seen in only four of the 26 lavages. 3. BAL cells released histamine in response to anti-human immunoglobulin E (IgE...
Clin Sci (Lond) (1984) 67 (5): 557–560.
Published: 01 November 1984
...M. P. Collins; K. Bakhshi; C. A. Wareham; M. K. Church 1. Histamine, both free and cell associated, has been demonstrated in middle ear fluid from patients with secretory otitis media (SOM). 2. Histamine, mainly free in solution, has also been shown to be present in nasopharyngeal secretions taken...
Clin Sci (Lond) (1984) 66 (3): 343–349.
Published: 01 March 1984
...Jay D. Coffman; Richard A. Cohen; Helen M. Rasmussen 1. The effect of intra-arterial histamine on fingertip blood flow (FBF) and vascular resistance (FVR) was studied in normal subjects during reflex sympathetic vascoconstriction induced by body cooling and vasoconstriction caused by intra-arterial...
Clin Sci (Lond) (1982) 62 (6): 661–665.
Published: 01 June 1982
...P. J. Barnes; P. W. Ind; M. J. Brown 1. Venous plasma histamine and catecholamines were measured in stable asthmatic subjects by a recently developed specific and sensitive radioenzymatic assay. 2. Plasma histamine concentrations were significantly elevated in both extrinsic and intrinsic asthmatic...
J. P. R. Hartley, T. J. Charles, R. D. H. Monie, A. Seaton, W. H. Taylor, A. Westwood, J. D. Williams
Clin Sci (Lond) (1981) 61 (2): 151–157.
Published: 01 August 1981
...J. P. R. Hartley; T. J. Charles; R. D. H. Monie; A. Seaton; W. H. Taylor; A. Westwood; J. D. Williams 1. Arterial plasma histamine concentrations, forced expiratory volume in 1.0 s (FEV 1.0 ) and peak expiratory flow rate were determined in nine patients with exercise-induced asthma and in five...
Clin Sci (Lond) (1981) 60 (4): 363–370.
Published: 01 April 1981
...Noemi M. Eiser; Jane Mills; P. D. Snashall; A. Guz 1. Eighteen non-asthmatic and 18 asthmatic subjects underwent challenge with increasing doses of histamine from a dosimeter—nebulizer system. Half the subjects in each group were atopic and half non-atopic. Bronchial response was monitored with...
Clin Sci (Lond) (1980) 59 (5): 389–391.
Published: 01 November 1980
...D. S. Rampton; R. D. Murdoch; G. E. Sladen 1. Rectal dialysis in vivo was used to assess rectal mucosal release of histamine in patients with ulcerative colitis and in control subjects. 2. Rectal mucosal histamine release was significantly increased in ulcerative colitis, whether the patients were...
Clin Sci (Lond) (1980) 58 (6): 537–544.
Published: 01 June 1980
...Noemi M. Eiser; Jane Mills; K. D. McRae; P. D. Snashall; A. Guz 1. Nine normal subjects inhaled increasing concentrations of histamine aerosol from an aerosol generator attached to a breath-actuated dosimeter. The responses were monitored by measuring specific airways-conductance in a body...
Clin Sci (Lond) (1979) 56 (3): 235–241.
Published: 01 March 1979
... only tested) had no protective effect. 5. Ipratropium bromide, bupivacaine and sodium cromoglycate were tested on histamine-induced bronchoconstriction in normal subjects. Half the normal subjects had an upper respiratory tract infection. Ipratropium bromide significantly reduced the fall in specific...
Clin Sci Mol Med (1976) 51 (5): 503–509.
Published: 01 November 1976
... of the patients during clinical remission acupuncture was performed before and after histamine aerosol challenge, but there was no effect on either the severity or the duration of the histamine-induced bronchoconstriction. 7. It is concluded that acupuncture probably reduced the reflex component of...
Clin Sci Mol Med (1974) 47 (2): 131–141.
Published: 01 August 1974
...M. Hobsley 1. Gastric juice was obtained during continuous maximal stimulation with histamine diphosphate, 0.13 μmol h −1 kg −1 (0.04 mg h −1 kg −1 ) intravenously, in thirty-four control subjects, twenty-eight patients with duodenal ulcer, and eighteen with gastric ulcer. After correction for...
Clin Sci Mol Med (1973) 45 (2): 193–198.
Published: 01 August 1973
... restricted diet. 2. There was no statistical difference between the excretion of MeIAA in urine in any of the groups. There was therefore no evidence of impairment of the methylation pathway of histamine metabolism in asthma. 23 2 1973 © 1973 The Biochemical Society and the Medical Research...
Clin Sci (1972) 42 (3): 301–309.
Published: 01 March 1972
...G. S. Harris; W. A. Palmer 1. Isolated rabbit arterial segments were perfused with buffer containing sodium (155 mmol/l) and vasoconstrictor responses to noradrenaline, histamine and electrical stimulation were measured. When the concentration of sodium in the perfusing medium was raised by 8 mmol...