... melanocytes. The elevated level of amino acid metabolite homocysteine (Hcy) has been identified as circulating marker of oxidative stress and known as a risk factor for vitiligo. However, the mechanism underlying Hcy-regulated melanocytic destruction is currently unknown. The present study aims to elucidate...

...) and determined the microbiome composition via 16S rRNA pyrosequencing and bioinformatics analysis of variable regions 3–4. We measured fasting levels of homocysteine (HCY), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α). Results revealed gut microbial dysbiosis in several patients with varying...

... intrahepatic resistance, increased portal-systemic collaterals and abnormal intra- and extra-hepatic vascular responsiveness. These derangements aggravate portal hypertension-related complications such as gastro-oesophageal variceal bleeding. Homocysteine, a substance implicated in cardiovascular diseases, has...

...Weili Zhang; Kai Sun; Jinxing Chen; Yuhua Liao; Qin Qin; Aiqun Ma; Daowen Wang; Zhiming Zhu; Yibo Wang; Rutai Hui Plasma homocysteine concentrations have been associated with the risk of stroke, but its relevance to secondary vascular events and mortality after stroke remains unclear because...

...Simona Sacco; Antonio Carolei After a long debate, due to conflicting data from clinical studies, homocysteine is now largely accepted as a risk factor for cardiovascular diseases including stroke. To date, the role of elevated homocysteine levels in stroke recurrences has not been evaluated...

...Manon V. Van Hecke; Jacqueline M. Dekker; Giel Nijpels; Tom Teerlink; Cornelis Jakobs; Ronald P. Stolk; Rob J. Heine; Lex M. Bouter; Bettine C.P. Polak; Coen D.A. Stehouwer The aim of the present study was to investigate the relationship between homocysteine and homocysteine metabolism components...

...Frank STAM; Yvo M. SMULDERS; Coen van GULDENER; Cornelis JAKOBS; Coen D. A. STEHOUWER; Kees de MEER Folic acid treatment decreases plasma total homocysteine concentrations in healthy subjects, but the effects on homocysteine metabolism are unknown. In the present study, we investigated the effect...

...) plasma homocysteine quartiles into a randomized double-blind placebo-controlled crossover trial. Following a 4-week course of placebo or folate/cyanocobalamin/pyridoxine supplements, FBF (forearm blood flow) was measured using venous occlusion plethysmography during intra-arterial substance P (4–16 pmol...

... studies point to an antioxidant effect of B-group vitamins and a pro-oxidant effect of elevated plasma tHcy (total homocysteine). In the present study, we assessed whether supplementary B-group vitamins during this critical period will enhance antioxidant capacity and mitigate oxidative damage. Forty...

...Richard J. WOODMAN; David E. CELERMAJER; Peter L. THOMPSON; Joseph HUNG Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we...

... with hyperhomocysteinaemia. This observation suggests that other factors must exist that modulate the relationship between hyperhomocysteinaemia and clinical disease. Therefore identifying factors that inhibit or enhance the vasculotoxic effects of homocysteine is important, as is elucidation of how homocysteine damages...

...Conor O'DOCHARTAIGH; Hean ONG; Sharon LOVELL; Ronan DONNELLY; Colm HANRATTY; Marshall RILEY; Michael FRENNEAUX; Ian YOUNG; Paul NICHOLLS Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar...

..., lipid peroxidation, cellular fibronectin and ferric reducing ability of plasma (FRAP; i.e. antioxidant capacity). After methionine loading, whole-blood levels of free and oxidized cysteine and homocysteine were increased in both groups. Furthermore, the total plasma levels of homocysteine were higher...

...Joey M. KAYE; Kim G. STANTON; Vincent J. MCCANN; Samuel D. VASIKARAN; Valerie BURKE; Roger R. TAYLOR; Frank M. VAN BOCKXMEER In the present study, the determinants of fasting plasma homocysteine in diabetic subjects were examined; whether plasma homocysteine and vascular disease are related...

...Colm G. HANRATTY; Daniel F. MCAULEY; Lawrence T. MCGRATH; Ian S. YOUNG; G. Dennis JOHNSTON A mild to moderate elevation of the total homocysteine concentration (tHcy) is now recognized as a risk factor for vascular disease. It is also associated with endothelial dysfunction in middle-aged...

...L. R. RANGANATH; M. BAINES; N. B. ROBERTS Homocysteine metabolism is increasingly implicated in a diverse group of clinical disorders, including atheromatous vascular disease. We studied the disposition of homocysteine via the trans-sulphuration pathway, plasma glutathione peroxidase (GPx) activity...

...Anthony ZULLI; Brian F. BUXTON; Laurie DOOLAN; James J. LIU 1. Patients with an elevated plasma level of either homocysteine or cholesterol are at increased risk of cardiovascular disease. Both methionine, the precursor of homocysteine, and cholesterol are found primarily in the same foods...

...Franziska M. T. Loehrer; Walter E. Haefeli; Christian P. Angst; Garry Browne; Greta Frick; Brian Fowler 1. Elevated plasma homocysteine concentration, either in the fasting state or after methionine loading, is an independent risk factor for vascular disease in man. Methionine loading has been used...

...D. E. L. Wilcken; Vatsala J. Gupta; A. K. Betts 1. Homocysteine which is formed during the metabolism of methionine is readily oxidized and is measured by the amino acid analyser as cysteine—homocysteine mixed disulphide and homocystine. We measured plasma amino acid concentrations after...

...D. E. L. Wilcken; Vatsala J. Gupta; S. G. Reddy 1. Plasma sulphur-containing amino acids were measured in 19 patients with renal failure on chronic haemodialysis and in 22 normal subjects, to determine the rate of accumulation of these amino acids in chronic azotaemia. 2. Cysteine-homocysteine...