...-established hypocalciuric action of hydrochlorothiazide, we have evaluated the effect of 15 days' treatment with hydrochlorothiazide in 10 hypercalciuric male stone-formers on urinary Ca 2+ and prostaglandin E 2 , as well as on plasma bicyclo-prostaglandin E 2 , 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D...

...S. J. Walter; D. G. Shirley 1. Hydrochlorothiazide was administered at two doses to Long-Evans rats for 7–10 days. Both doses resulted in an initial natriuresis and diuresis. After 1 day of treatment the natriuresis abated, but the diuresis persisted. 2. The mechanisms responsible for these chronic...

...L. Monnens; A. Jonkman; C. Thomas 1. Four boys with classical nephrogenic diabetes insipidus have been treated by indomethacin, by hydrochlorothiazide, and by the combination of indomethacin and hydrochlorothiazide. 2. Hydrochlorothiazide treatment was slightly more effective than indomethacin...

...D. G. Shirley; S. J. Walter; J. F. Laycock 1. Brattleboro rats with hereditary diabetes insipidus were maintained in metabolism cages for 12–14 days. During the final 5–7 days hydrochlorothiazide was added to the food of half the animals, resulting in a sustained antidiuresis. At the end...

...S. J. Walter; J. Skinner; J. F. Laycock; D. G. Shirley 1. The antidiuretic effect of hydrochlorothiazide in diabetes insipidus was investigated in rats with the hereditary hypothalamic form of the disease (Brattleboro rats). 2. Administration of hydrochlorothiazide in the food resulted in a marked...

... well. CBI was more effective than hydrochlorothiazide, which at 2.2 mg/100 g body wt. daily only lowered the SBP to 167 ± 5 mmHg. The combined administration of CBI and hydrochlorothiazide produced an additive effect in that the SBP was reduced to 126 ± 4 mmHg. 4. CBI treatment resulted in a 36% and 11...

...Bonita Falkner; Gaddo Onesti; Melton B. Affrime; David T. Lowenthal 1. The effects of clonidine and hydrochlorothiazide on the cardiovascular responses to mental stess were compared in 29 adolescents with essential hypertension. 2. Clonidine therapy was associated with lower diastolic pressures...

... were given hydrochlorothiazide (25 mg twice daily), as were two-thirds of each captopril-treated group, and they were observed for 7 additional weeks. 3. Captopril reduced blood pressure by 12.2 ± 0.8/9.4 ± 0.4 mmHg at 7 weeks (n = 323) and captopril plus placebo by 10.3 ± 1.9/10.2 ± 0.9 at 14 weeks...

... in urinary calcium excretion. In an attempt to prevent this increase, thyroparathyroidectomized rats receiving 1,25(OH) 2 D 3 were also treated with hydrochlorothiazide for 9–11 days. 2. Calcium clearance studies show that hydrochlorothiazide stimulated the tubular reabsorption of calcium...

...P. Van Brummelen; A. Man In 't Veld; M. A. D. H. Schalekamp 1. Blood pressure, systemic haemodynamics, plasma volume, renin and aldosterone were measured during placebo treatment and after 1, 4 and 12 weeks of hydrochlorothiazide in 13 patients with uncomplicated essential hypertension. Nine...

...A. Lechi; G. Covi; G. Danti; A. Dalla Riva; E. Pedrolli; S. Pomari 1. Tienilic acid and hydrochlorothiazide were evaluated in a double-blind trial in order to investigate their antihypertensive and metabolic effects. 2. After 5 weeks, the decreases in blood pressure and the changes in plasma...

... of hydrochlorothiazide kept arterial pressure significantly below pretreatment control values. © 1979 The Biochemical Society and the Medical Research Society 1979 aldosterone captopril converting enzyme hydrochlorothiazide renin Clinical Science (1979) 5 7 , 3 7 1 ~ 3 7 3 s Response of arterial blood...

...S. J. Walter; J. F. Laycock; D. G. Shirley 1. Renal function in anaesthetized Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied with micropuncture techniques before, and 1–3 h after, a single injection of hydrochlorothiazide. 2. In rats given hydrochlorothiazide and kept...

...P. Van Brummelen; M. Woerlee; M. A. D. H. Schalekamp 1. Renal blood flow, glomerular filtration rate, renal vascular resistance and filtration fraction were studied in ten patients with essential hypertension, during placebo, and after 1 week, 3, 6 and 9 months of hydrochlorothiazide. Plasma renin...

... and randomization half were treated with one capsule daily containing 25 mg of hydrochlorothiazide and 50 mg of triamterene and half were given placebo. In those receiving active treatment, if blood pressure control was not adequate they were given a second capsule and if necessary up to 2 g of methyldopa/day. 2...

... epidemiology hydrochlorothiazide hypertension methyldopa timolol © 1978 The Biochemical Society and the Medical Research Society 1978 Clinical Science and Molecular Medicine (1978) 55,353s-354s Results of a national therapeutic trial conducted in 10 000 hypertensive patients by 2000 general...

...D. G. Shirley; S. J. Walter; J. F. Laycock 1. The mechanism of the antidiuretic effect of hydrochlorothiazide in diabetes insipidus was studied in anaesthetized Brattleboro rats with the hereditary hypothalamic form of the disease. 2. The antidiuresis caused by acute administration...

...C. S. Sweet; M. Mandradjieff 1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure...

...P. Lund-Johansen 1. The effects of hypotensive therapy with three separate diuretics, methyldopa and clonidine were separately assessed. 2. All the treated groups showed a significant drop in blood pressure. 3. Polythiazide and hydrochlorothiazide each produced a significant fall in total...