..., gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H 2 S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown...

...Valentina Vellecco; Antonio Mancini; Angela Ianaro; Vincenzo Calderone; Chiara Attanasio; Anna Cantalupo; Barbara Andria; Gennaro Savoia; Elisabetta Panza; Antonietta Di Martino; Giuseppe Cirino; Mariarosaria Bucci Hydrogen sulfide is an endogenous gasotransmitter and its mechanism of action...

...Vaibhav B. Patel; Brent A. McLean; Xueyi Chen; Gavin Y. Oudit Diabetic cardiovascular complications are reaching epidemic proportions and the risk of HF (heart failure) is increased 2–3-fold by diabetes mellitus. H 2 S (hydrogen sulfide) is emerging as a new gaseous signalling molecule...

... the Nrf2/ARE pathway and exert anti-apoptotic effects by inhibiting JNK and p38 MAPK pathways and activating PI3K/Akt signalling. apoptosis diabetic cardiomyopathy hydrogen sulfide inflammation oxidative stress • There is growing evidence that H 2 S has beneficial effects in treatment...

... of pulmonary endothelium, extravasation of protein-rich fluid into the interstitium and formation of oedema. Recently, H 2 S (hydrogen sulfide) has been shown to decrease the synthesis of pro-inflammatory cytokines, reduce leucocyte adherence to the endothelium and subsequent diapedesis of these cells from...