... in sensation seen with hypercapnia. 2. To investigate this we measured hypercapnic re-breathing responses in seven normal subjects (six males, age range 21–38 years) with and without an inspiratory resistive load of 10 cm H 2 O. Pleural and transdiaphragmatic pressures, mouth occlusion pressure and breathing...

... analogue scaling as a means of improving the temporal resolution of this measurement. 2. Six normal naive subjects scaled breathlessness using a visual analogue scale, during steady-state exercise. Further changes in this sensation were induced by either sustained hypercapnia or acute hypoxia...

...J. M. Low; T. Gin; T. W. Lee; K. Fung 1. Plasma concentrations of noradrenaline and adrenaline were measured in 11 anaesthetized patients during normocapnia, hypocapnia and hypercapnia. Hypocapnia was produced by deliberate hyperventilation and hypercapnia by adding carbon dioxide to the inspired...

...T. A. D. Cadoux-Hudson; B. Rajagopalan; J. G. G. Ledingham; G. K. Radda 1. The aim of this investigation was to measure the change in intracellular pH of human brain in vivo in response to hypercapnia. 2. Five healthy male subjects inspired air for 20 min and then 5% CO 2 /95% O 2 for 30 min...

.... No subject demonstrated resting awake hypercapnia and none suffered from sleep-disordered breathing. 2. Mean weight fell significantly (122.8 ± 21.4 vs 102.2 ± 22.8 kg, P <0.0001) and functional residual capacity rose slightly but significantly (1.94 ± 0.58 vs 2.18 ± 0.64 litres; P <0.05) after weight...

...Jean-Paul Clozel; Claude Saunier; Denise Hartemann; Mustapha Allam; Walter Fischli 1. The aim of the present study was to assess the effects of hypercapnia or hypoxia on plasma concentrations of atrial natriuretic factor (ANF) in conscious unrestrained dogs. 2. For this purpose, chronically...

... of central processing than upon input from peripheral mechanoreceptors. Key words: breathlessness, exercise, hypercapnia, lung mechanics, obstructive airways disease, scaling, ventila- tion. Abbreviations: TLC, total lung capacity; VAS, visual analogue scale; VE, expired minute ventilation; VT, tidal volume...

...D. L. Maxwell; K. B. Nolop; J. M. B. Hughes 1. In seven normal subjects the ventilatory responses to progressive isocapnic hypoxia and hyperoxic hypercapnia were measured during rebreathing. 2. During an infusion of somatostatin (10 nmol/mm) the mean hypoxic response decreased by 66% (control...

... 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 glomerular filtration hypercapnia hypoxia renal blood flow Clinical Science (1983) 65, 533-538 533 Effect of hypoxia and hypercapnic acidosis on renal autoregulation in the dog: role of renal nerves ROBERT J...

..., at therapeutic concentrations in normal unanaesthetized subjects. chemosensitivity doxapram hypercapnia ventilation Clinical Science (1983) 65, 65-69 65 The ventilatory effects of doxapram in normal man P. M. A. CALVERLEY', R. H. ROBSON', P. K. WRAITH', L. F. PRESCOTT2 A N D D. C. FLENLEY3 'Departments...

... stable patients with chronic airflow obstruction and chronic hypercapnia ( P aco 2 7.1 ± 0.5 kPa, mean ± sd). 2. Seven men, aged from 55 to 64 years, had the following values for pulmonary function (means ± sd): FEV 1.0 0.67 ± 0.16 litre; VC 2.12 ± 0.52 litres; FEV 1.0 /VC 33 ± 8%. They had haemodynamic...

... © 1982 The Biochemical Society and the Medical Research Society 1982 almitrine hypercapnia hypoxia respiratory stimulant Clinical Science (1982) 63,401-404 40 1 SHORT COMMUNICA TION The effects of almitrine on the ventilatory response to hypoxia and hypercapnia in normal subjects J. R...

... of a multichannel video-angiometer under resting conditions and under maximal vasodilatation induced by hypercapnia. 2. Initial mean arterial pressure was 172 ± sem 9 mmHg in SHR and 103 ± 5 mmHg in WKY rats; during hypercapnia the corresponding values were 183 ± 9 and 127 ± 7 mmHg. 3. The resting diameter...

...P. W. Trembath; Elizabeth A. Taylor; J. Varley; P. Turner 1. The effect of a single oral dose of propranolol on the ventilatory response to hypercapnia has been studied in five healthy subjects. 2. Propranolol produced a small but significant reduction in the slope of the ventilation/end-tidal P co...

... on the chemical control of breathing in man is discussed in relation to the conflicting literature. 28 12 1977 3 7 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 β-adrenoreceptor blockade chemoreceptors hypercapnia hypoxia propranolol respiration Clinical...

... 1978 carbon dioxide environmental chamber hypercapnia pulmonary viscous work respiratory response to CO 2 ventilatory response to CO 2 Clinical Science and Molecular Medicine (1978), 55,309-3 16 The respiratory response to inhaled carbon dioxide in man after 3 hours exposure to 3% carbon...

.... Except at low lactate concentrations, non-ionic diffusion probably does not play a major role in the entry of lactate into the hepatocyte. 5 12 1977 20 3 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 gluconeogenesis hypercapnia hypocapnia...

... The Biochemical Society and the Medical Research Society 1978 hypercapnia hypocapnia intracellular pH lactate lactic acidosis Clinical Science and Molecular Medicine (1978) 55,175-181 Effect of varying Pco, on intracellular pH and lactate consumption in the isolated perfused rat liver P. G . BARON, R...

... and the Medical Research Society 1978 breathing pattern hypercapnia lung mouth occlusion pressure Clinical Science and Molecular Medicine (1978), 54,295-304 Control of breathing in patients with chronic obstructive lung disease J. SORLI, A. GRASSINO, G. LORANGE AND J. MILIC-EMILI Department...

... of the ventilatory, frequency and tidal volume responses to carbon dioxide. It is concluded that task performance does not improve the reproducibility of these responses. 29 7 1976 16 10 1976 © 1977 The Biochemical Society and the Medical Research Society 1977 hypercapnia mental arithmetic...

... Society 1977 acid-base equilibrium blood gas analysis hypercapnia Clinical Science and Molecular Medicine (1977) 52, 61-14. Acid-base and respiratory changes after prolonged exposure to 1% carbon dioxide B. J. W. PINGREE Tenth Submarine Squadron, Royal Navy, and Department of Bioengineering...

...G. J. Dusting; Janina Staszewska-Barczak 1. The blood-bathed organ technique was used to study the release of catecholamines, angiotensin II and prostaglandin-like (PL) substances into the circulation during hypercapnia and after haemorrhage in anaesthetized dogs. 2. Elevated blood concentrations...

... of areas of increased permeability. 4. Ligation of a carotid artery prevents lesions in the ipsilateral hemisphere. Key words : angiotensin, blood-brain barrier, hypercapnia, hypertension, hyperventilation. Introduction The endothelial cells of the cerebral vessels have a low pinocytotic activity...