...Ching-Hsia Hung; Shih-Hung Chan; Pei-Ming Chu; Kun-Ling Tsai HHcy (hyperhomocysteinaemia) is one of the major risk factors for cardiovascular diseases. A high concentration of Hcy (homocysteine) induces endothelial dysfunction by activating endothelial oxidative stress. LOX-1 (lectin-like oxidized...

...) atherosclerosis endothelium hyperhomocysteinaemia peroxisome-proliferator-activated receptor γ (PPARγ) rosiglitazone Protein was extracted from the coronary sinus area of snap-frozen aorta as previously described [ 21 ]. Protein (100 μg) was separated by electrophoresis on a 10% polyacrylamide gel...

.... We conclude that, in the absence of alterations in endothelium-dependent vasomotion or platelet aggregation, substance P-induced t-PA release is enhanced following methionine loading. This suggests that the acute endogenous fibrinolytic capacity is augmented during acute hyperhomocysteinaemia...

...Stuart J. MOAT; James R. BONHAM; Hilary J. POWERS Hyperhomocysteinaemia is considered to be an independent risk factor for vascular disease. Elevated plasma homocysteine may pose an oxidative stress, leading to the development of vascular damage. A component of this effect may be a disturbance...