...Ching-Hsia Hung; Shih-Hung Chan; Pei-Ming Chu; Kun-Ling Tsai HHcy (hyperhomocysteinaemia) is one of the major risk factors for cardiovascular diseases. A high concentration of Hcy (homocysteine) induces endothelial dysfunction by activating endothelial oxidative stress. LOX-1 (lectin-like oxidized...

... Care Committee of the Lady Davis Institute and conducted in accordance with recommendations of the Canadian Council of Animal Care. Mice heterozygous for disruption of the mthfr gene presenting mild hyperhomocysteinaemia were generated at the Montreal Children's Hospital Research Institute...

.... We conclude that, in the absence of alterations in endothelium-dependent vasomotion or platelet aggregation, substance P-induced t-PA release is enhanced following methionine loading. This suggests that the acute endogenous fibrinolytic capacity is augmented during acute hyperhomocysteinaemia...

...Stuart J. MOAT; James R. BONHAM; Hilary J. POWERS Hyperhomocysteinaemia is considered to be an independent risk factor for vascular disease. Elevated plasma homocysteine may pose an oxidative stress, leading to the development of vascular damage. A component of this effect may be a disturbance...