...A. K. Salahudeen; T. H. Thomas; L. Sellars; S. Tapster; P. Keavey; J. R. Farndon; I. D. A. Johnston; R. Wilkinson 1. Twenty-four patients with primary hyperparathyroidism were studied before and 18 restudied 6.5 months (mean) after parathyroidectomy, to investigate the pathogenesis...

...B. C. Lalor; E. B. Mawer; M. Davies; G. A. Lumb; L. Hunt; P. H. Adams 1. The serum concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured in 44 patients with primary hyperparathyroidism. 2. In 14 patients the serum concentration of 1,25-dihydroxyvitamin D was greater than...

...M. R. Clements; M. Davies; D. R. Fraser; G. A. Lumb; E. Barbara Mawer; P. H. Adams 1. The elimination half-time of 25-hydroxyvitamin D in plasma was estimated after intravenous injection of the radioactively labelled metabolite in seven patients with primary hyperparathyroidism before and after...

.... 4. A rise in resorption parameters and in serum parathyroid hormone levels was observed in patients with osteomalacia. The percentage reductions in stainable aluminium and in osteoid volume were correlated with the degree of hyperparathyroidism. 5. These data show that deferoxamine therapy reduces...

... and 60 patients with primary or secondary hyperparathyroidism. The lower limit of detectability was 150 pg/ml in terms of synthetic human PTH (1-34). 2. PTH-like bioactivity was not detected in normal subjects, in patients with surgical hypoparathyroidism, in patients with idiopathic hypoparathyroidism...

...D. Saltissi; G. D. Carter 1. 51 Cr red cell mass (RCM), 51 Cr red cell survival (RCS) and plasma parathyroid hormone (PTH) levels were measured in 27 stable chronic haemodialysis patients with a variable degree of clinical secondary hyperparathyroidism. Included were five patients who had had total...

... reduced the hypertension, and parathyroidectomy improved the abnormal sensitivity to noradrenaline in group A rats. 5. These results raise the possibility that an abnormality in calcium metabolism, possibly due to secondary hyperparathyroidism, may be implicated in the hypertension of mildly uraemic rats...

...-menopausal women with various degrees of simple osteoporosis, but a few cases of hyperparathyroidism and other calcium disorders were included. 2. Calcium balance, bone resorption rate, urinary hydroxyproline and plasma alkaline phosphatase were shown to be related to the rate of bone loss; patients...

... renal failure as compared with those of normal subjects. Mean amounts of peak II were higher in patients with chronic renal insufficiency than in nutritional vitamin D deficiency, in pseudohypoparathyroidism and in primary hyperparathyroidism, despite comparable amounts of PTH-(1–84). 3. In chronic...

..., normal volunteer subjects, primary hyperparathyroid patients before and after surgery and patients with secondary hyperparathyroidism. 3. In primary and secondary hyperparathyroidism the biological activity was significantly higher than in urine from normal subjects, which was in turn significantly...

...D. A. Walker; S. Joyce Davies; K. Siddle; J. S. Woodhead 1. The maximum tubular reabsorption capacity for phosphate relative to glomerular filtration rate (T m,P /GFR) was found to range from 0·8 to 1·5 mmol/l in 32 normal fasting subjects. In 14 patients with primary hyperparathyroidism and five...

... increase in plasma cyclic AMP was observed after administration of bovine parathyroid hormone to patients with severe chronic renal failure. 3. Even when renal function was not impaired, some patients with primary hyperparathyroidism, who had high concentrations of endogenous parathyroid hormone, showed...

...M. Kaye 1. The direct effect of calcium on the hyperparathyroidism of chronic renal failure was studied in rats with induced chronic renal failure, who were fed on a diet low in phosphate and who received supplemental phosphate by injection. They were given a normal (0·8%), or low (0·1%) or high (1...

...A. M. Parfitt 1. The bivalent cation-binding agent, cellulose phosphate, together with a low calcium diet was given for 6 days to nine patients with primary hyperparathyroidism subsequently verified at surgery. 2. Urinary calcium fell promptly by 8·4 mmol/24 h, and by 70%, and reached amounts below...

...J. C. Gallagher; R. Wilkinson 1. Eight post-menopausal women with primary hyperparathyroidism were given ethinyloestradiol (0.05 mg daily) and the effects on calcium and phosphorus metabolism were observed. 2. In every patient ethinyloestradiol produced a fall in fasting plasma and urine calcium...

... device attached to a digital computer. 2. Areas of uncalcified osteoid are quantified by visual inspection during photography and the skeletal lesions of hyperparathyroidism are assessed semi-quantitatively. 3. This system makes it possible to define osteoporosis and osteomalacia according...

...D. J. Hosking; M. J. Chamberlain; J. H. Fremlin 1. The change in total body calcium content after surgery for primary hyperparathyroidism was studied in seven patients by whole body neutron activation analysis. Three patients who remained in the uncontrolled state for up to 12 months were also...