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1-19 of 19
Keywords: hypertriglyceridaemia
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Articles
Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats
Available to PurchaseBárbara Maiztegui, María I. Borelli, Viviana G. Madrid, Héctor Del Zotto, María A. Raschia, Flavio Francini, María L. Massa, Luis E. Flores, Oscar R. Rebolledo, Juan J. Gagliardino
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (2): 73–80.
Published: 08 October 2010
... hypertriglyceridaemia insulin resistance pre-diabetes sitagliptin T2DM (Type 2 diabetes mellitus) represents a serious health problem worldwide due to its high and growing incidence and to the negative impact of its associated complications upon quality of life and healthcare costs [ 1 ]. To cope...
Articles
Apolipoprotein C-III: understanding an emerging cardiovascular risk factor
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (10): 611–624.
Published: 14 April 2008
... with the obesity epidemic. Dyslipidaemia in the metabolic syndrome is potently atherogenic and, hence, is a major risk factor for CVD (cardiovascular disease) in these subjects. It is globally characterized by hypertriglyceridaemia, near normal LDL (low-density lipoprotein)-cholesterol and low plasma HDL (high...
Articles
Familial combined hyperlipidaemia: how can genetic disorders be common, complex and comprehensible?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (9): 365–367.
Published: 01 October 2007
...) hypertriglyceridaemia lipid phenotype lipoprotein liver steatosis Knowing the sequence of our genes does not automatically mean we know how they cause vascular disease. To be sure, in a few monogenic disorders, such as FH (familial hypercholesterolaemia), there is a simple short straight line between genetic...
Articles
Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia
Available to PurchaseMartijn C. G. J. Brouwers, Marleen M. J. van Greevenbroek, Vicky M. M.-J. Vermeulen, Josephine M. J. P. van Lin, Carla J. H. van der Kallen, Tjerk W. A. de Bruin
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (9): 375–381.
Published: 01 October 2007
... to develop hypertriglyceridaemia in FCHL. BMI (body mass index), waist circumference and plasma triacylglycerols, insulin and ALT levels were measured in 145 FCHL family members and 54 spouses at baseline and after a 5-year follow-up. A switch from normotriglyceridaemia to hypertriglyceridaemia or vice versa...
Articles
Fatty liver is an integral feature of familial combined hyperlipidaemia: relationship with fat distribution and plasma lipids
Available to PurchaseMartijn C. G. J. Brouwers, Monique A. L. Bilderbeek-Beckers, Anna M. Georgieva, Carla J. H. van der Kallen, Marleen M. J. van Greevenbroek, Tjerk W. A. de Bruin
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (2): 123–130.
Published: 11 December 2006
...) hypertriglyceridaemia insulin resistance steatosis subcutaneous adiposity very-low-density lipoprotein (VLDL) visceral adiposity More than 30 years ago, FCHL (familial combined hyperlipidaemia) was delineated as a genetic hyperlipidaemia, characterized by the presence of different hyperlipidaemic...
Articles
The adipocyte life cycle hypothesis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (1): 1–9.
Published: 12 December 2005
... is shifted to the left in upper-body compared with lower-body adipocytes. This results in larger transmembrane FA fluxes at any given adipocyte size. adipose tissue apolipoprotein B (apoB) fatty acid metabolism hypertriglyceridaemia obesity The adipocyte life cycle hypothesis relates...
Articles
A compound heterozygote for a novel missense mutation (G105R) in exon 3 and a missense mutation (D204E) in exon 5 of the lipoprotein lipase gene in a Japanese infant with hyperchylomicronaemia
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (6): 569–578.
Published: 21 November 2000
...Yasuyuki IKEDA; Katsumi GOJI; Atsuko TAKAGI We systematically investigated the molecular defects resulting in primary lipoprotein lipase (LPL) deficiency in a Japanese male infant (hereafter called ‘the patient’) with severe fasting hypertriglyceridaemia (type I hyperlipoproteinaemia). The primary...
Articles
Sodium—Lithium Countertransport, Sodium—Hydrogen Exchange and Membrane Microviscosity in Patients with Hyperlipidaemia
Available to PurchaseM. J. MacLeod, W. K. Lee, A. M. Devlin, M. Caslake, N. H. Anderson, C. J. Packard, M. H. Dominiczak, J. L. Reid, A. F. Dominiczak
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (3): 237–246.
Published: 01 March 1997
... with hypertriglyceridaemia and 54 normolipaemic controls. Full lipid profile, blood pressure, body mass index, fasting glucose and insulin levels were also measured. 2. Subjects with hypertriglyceridaemia had higher blood pressure, body mass index, fasting glucose and insulin levels than normal controls. 3. V max...
Articles
Lipoprotein Profiles in a Family with Two Mutants of Apolipoprotein E: Possible Association with Hypertriglyceridaemia but Not with Dysbetalipoproteinaemia
Available to PurchaseShui-Ping Zhao, Arn M. J. M. Van den Maagdenberg, Ton F. F. P. Vroom, Ferdinand M. Van't Hooft, Jan A. Gevers Leuven, Louis M. Havekes, Rune R. Frants, Arnoud Van Der Laarse, Augustinus H. M. Smelt
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (3): 323–329.
Published: 01 March 1994
... carrying APOE*3-(Cys-112→Arg; Arg-251→Gly) and/or APOE*2(Val-236→Glu) exhibited lipoprotein abnormalities characteristic of familial dysbetalipoproteinaemia, although three family members carrying APOE*3-(Cys-112→Arg; Arg-251→Gly) showed hypertriglyceridaemia. 27 9 1993 4 10 1993 © 1994...
Articles
Serum Sialic Acid and Acute-Phase Proteins in Hypertriglyceridaemic Patients Showing the Frederickson's Type IIB Phenotype
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (2): 219–222.
Published: 01 August 1993
... patients. 26 3 1993 15 4 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 acute-phase proteins cardiovascular risk hypertriglyceridaemia sialic acid Clinical Science (1993) 85, 219-222 (Printed in Great Britain) Serum sialic acid and acute-phase...
Articles
Relationship between Serum Butyrylcholinesterase Activity, Hypertriglyceridaemia and Insulin Sensitivity in Diabetes Mellitus
Available to PurchaseC. A. Abbott, M. I. MacKness, S. Kumar, A. O. Olukoga, C. Gordon, S. Arrol, D. Bhatnagar, A. J. M. Boulton, P. N. Durrington
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (1): 77–81.
Published: 01 July 1993
... in the normal range. 6. These results are consistent with the view that butyrylcholinesterase may have a role in the altered lipoprotein metabolism in hypertriglyceridaemia associated with insulin insensitivity or insulin deficiency in diabetes mellitus. 24 3 1993 6 4 1993 © 1993...
Articles
Serum sialic acid concentration in patients with hypertriglyceridaemia showing the Frederickson's IIB phenotype
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (5): 593–595.
Published: 01 November 1992
...M. Crook; P. Tutt 1. Serum total sialic acid concentration, recently shown to be a cardiovascular risk factor, and also serum lipid-associated sialic acid concentration were measured in 15 patients with hypertriglyceridaemia (fasting serum triacylglycerol concentration > 2.3 mmol/l) showing...
Articles
Effects of Acipimox, a Nicotinic Acid Derivative, on Lipolysis in Human Adipose Tissue and on Cholesterol Synthesis in Human Jejunal Mucosa
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (1): 83–88.
Published: 01 January 1985
... © 1985 The Biochemical Society and the Medical Research Society 1985 acipimox adipose tissue cholesterol synthesis hypercholesterolaemia hypertriglyceridaemia jejunum lipolysis ...
Articles
The Roles of C-Apolipoproteins in the Metabolism of Triglyceride-Rich Lipoproteins
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Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (2): 125–129.
Published: 01 February 1982
...J. P. D. Reckless; J. Stocks; G. Holdsworth © 1982 The Biochemical Society and the Medical Research Society 1982 apolipoproteins C-apoproteins. high-density lipoproteins hypertriglyceridaemia lipoproteins triglyceride-rich lipoproteins. very-low-density lipoproteins Clinical Science...
Articles
Studies of a Variant Very-Low-Density Lipoprotein with an Acquired Deficiency of Apolipoprotein C-II
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1982) 62 (1): 93–100.
Published: 01 January 1982
...J. P. D. Reckless; J. Stocks; G. Holdsworth; D. J. Galton; A. J. Suggett; K. W. Walton 1. A variant very-low-density lipoprotein was associated with severe hypertriglyceridaemia. Urea—polyacrylamide gel electrophoresis of the tetramethylurea-soluble apolipoproteins of these very-low-density...
Articles
Plasma High-Density Lipoprotein Metabolism in Subjects with Primary Hypertriglyceridaemia: Altered Metabolism of Apoproteins AI and AII
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1980) 59 (5): 359–367.
Published: 01 November 1980
... hypertriglyceridaemia appears to be frequently associated with divergent abnormalities of the metabolism of the major high-density lipoprotein apoproteins. 31 1 1980 13 6 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 apoprotein AI apoprotein AII high-density...
Articles
The Esterification of Exogenous Fatty Acids by Adipose Tissue of Hypertriglyceridaemic Subjects with or without Diabetes Mellitus
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1976) 51 (3): 257–265.
Published: 01 September 1976
...P. Clifton-Bligh; D. J. Galton 1. The esterification of exogenous palmitate to diglyceride and triglyceride in adipocytes was studied in obese and diabetic patients with and without hypertriglyceridaemia. The rate of esterification correlated significantly with the triglyceride content...
Articles
Post-Heparin Plasma Lipoprotein Lipase and Hepatic Lipase in Normal Subjects and in Patients with Hypertriglyceridaemia: Correlations to Sex, Age and Various Parameters of Triglyceride Metabolism
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1976) 50 (4): 249–260.
Published: 01 April 1976
...J. K. Huttunen; C. Ehnholm; M. Kekki; E. A. Nikkilä 1. A selective immunochemical method was used to measure post-heparin plasma lipoprotein lipase and hepatic lipase activity in eighty-two normal subjects and in twenty patients with type IIb, IV or V hypertriglyceridaemia. In twenty-six normal...
Articles
Plasma Post-Heparin Lipolytic Activity in Patients with Malabsorption: Effect of Intravenous Fat Administration
Available to Purchase
Journal:
Clinical Science
Clin Sci Mol Med (1974) 46 (6): 743–751.
Published: 01 June 1974
... in origin. They also suggest that if reduced clearance is a factor in the hypertriglyceridaemia sometimes seen in malabsorption, it is due to an enzyme deficit rather than a substrate defect. 29 11 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 post-heparin...