... compilation © 2011 Biochemical Society 2011 β-cell mass exendin-4 hypertriglyceridaemia insulin resistance pre-diabetes sitagliptin OGTT was performed in 12-h fasted rats from each experimental group 24 h prior to sacrifice. Glucose (1 g/kg of body weight in saline solution) was given through...

... with the obesity epidemic. Dyslipidaemia in the metabolic syndrome is potently atherogenic and, hence, is a major risk factor for CVD (cardiovascular disease) in these subjects. It is globally characterized by hypertriglyceridaemia, near normal LDL (low-density lipoprotein)-cholesterol and low plasma HDL (high...

... members with FCHL, so did hypertriglyceridaemia, hyperinsulinaemia and increased hepatic triacylglycerol (triglyceride) content as reflected in plasma ALT (alanine aminotransferase) levels. What is interesting is that this relationship was much more obvious in the FCHL family members than in their spouses...

... to develop hypertriglyceridaemia in FCHL. BMI (body mass index), waist circumference and plasma triacylglycerols, insulin and ALT levels were measured in 145 FCHL family members and 54 spouses at baseline and after a 5-year follow-up. A switch from normotriglyceridaemia to hypertriglyceridaemia or vice versa...

...) hypertriglyceridaemia insulin resistance steatosis subcutaneous adiposity very-low-density lipoprotein (VLDL) visceral adiposity In summary, we have shown that not only FCHL patients, but also their NL relatives, have a 3-fold higher risk of developing fatty liver compared with spouses. Within the FCHL...

... metabolism hypertriglyceridaemia obesity However, there is yet another mode to deliver FA to the liver, namely the FAs still present as triacylglycerol within the chylomicron particles, which were attached to the capillary endothelium and had been acted on by LPL (lipoprotein lipase), but were...

...Yasuyuki IKEDA; Katsumi GOJI; Atsuko TAKAGI We systematically investigated the molecular defects resulting in primary lipoprotein lipase (LPL) deficiency in a Japanese male infant (hereafter called ‘the patient’) with severe fasting hypertriglyceridaemia (type I hyperlipoproteinaemia). The primary...

... with hypertriglyceridaemia and 54 normolipaemic controls. Full lipid profile, blood pressure, body mass index, fasting glucose and insulin levels were also measured. 2. Subjects with hypertriglyceridaemia had higher blood pressure, body mass index, fasting glucose and insulin levels than normal controls. 3. V max...

... carrying APOE*3-(Cys-112→Arg; Arg-251→Gly) and/or APOE*2(Val-236→Glu) exhibited lipoprotein abnormalities characteristic of familial dysbetalipoproteinaemia, although three family members carrying APOE*3-(Cys-112→Arg; Arg-251→Gly) showed hypertriglyceridaemia. 27 9 1993 4 10 1993 © 1994...

... patients. 26 3 1993 15 4 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 acute-phase proteins cardiovascular risk hypertriglyceridaemia sialic acid Clinical Science (1993) 85, 219-222 (Printed in Great Britain) Serum sialic acid and acute-phase...

... in the normal range. 6. These results are consistent with the view that butyrylcholinesterase may have a role in the altered lipoprotein metabolism in hypertriglyceridaemia associated with insulin insensitivity or insulin deficiency in diabetes mellitus. 24 3 1993 6 4 1993 © 1993...

...M. Crook; P. Tutt 1. Serum total sialic acid concentration, recently shown to be a cardiovascular risk factor, and also serum lipid-associated sialic acid concentration were measured in 15 patients with hypertriglyceridaemia (fasting serum triacylglycerol concentration > 2.3 mmol/l) showing...

...)-triglyceride and VLDL synthesis. acipimox adipose tissue cholesterol synthesis hypercholesterolaemia hypertriglyceridaemia jejunum lipolysis 18 7 1984 2 8 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 Clinical Science (1985) 68, 83-88 83 Effects...

...J. P. D. Reckless; J. Stocks; G. Holdsworth © 1982 The Biochemical Society and the Medical Research Society 1982 apolipoproteins C-apoproteins. high-density lipoproteins hypertriglyceridaemia lipoproteins triglyceride-rich lipoproteins. very-low-density lipoproteins Clinical Science...

...J. P. D. Reckless; J. Stocks; G. Holdsworth; D. J. Galton; A. J. Suggett; K. W. Walton 1. A variant very-low-density lipoprotein was associated with severe hypertriglyceridaemia. Urea—polyacrylamide gel electrophoresis of the tetramethylurea-soluble apolipoproteins of these very-low-density...

... hypertriglyceridaemia appears to be frequently associated with divergent abnormalities of the metabolism of the major high-density lipoprotein apoproteins. 31 1 1980 13 6 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 apoprotein AI apoprotein AII high-density...

...P. Clifton-Bligh; D. J. Galton 1. The esterification of exogenous palmitate to diglyceride and triglyceride in adipocytes was studied in obese and diabetic patients with and without hypertriglyceridaemia. The rate of esterification correlated significantly with the triglyceride content...

...J. K. Huttunen; C. Ehnholm; M. Kekki; E. A. Nikkilä 1. A selective immunochemical method was used to measure post-heparin plasma lipoprotein lipase and hepatic lipase activity in eighty-two normal subjects and in twenty patients with type IIb, IV or V hypertriglyceridaemia. In twenty-six normal...

... in origin. They also suggest that if reduced clearance is a factor in the hypertriglyceridaemia sometimes seen in malabsorption, it is due to an enzyme deficit rather than a substrate defect. 29 11 1973 © 1974 The Biochemical Society and the Medical Research Society 1974 post-heparin...