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Keywords: hypertrophy
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Articles
Clin Sci (Lond) (2024) 138 (18): 1173–1177.
Published: 18 September 2024
... and enhanced systolic function with no evidence of arrhythmia in IGF1R model, as well as ventricular hypertrophy and decreased systolic function with intermittent atrial fibrillation in DCM-dnPI3K model. Novel findings obtained from the left atrial (LA) characterization of female mice revealed...
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Clin Sci (Lond) (2020) 134 (5): 513–527.
Published: 09 March 2020
... smooth muscle cell (VSMC) hypertrophy and phenotype changes, in the absence of extracellular matrix (ECM) proteins accumulation. Accordingly, treatment with an IL-17A neutralizing antibody diminished SMA remodeling in a model of angiotensin II (Ang II) infusion. Moreover, in vitro studies in VSMCs...
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Clin Sci (Lond) (2017) 131 (13): 1375–1392.
Published: 23 June 2017
... the mutation rate is low, and screens have failed to detect PLN mutations [ 39 , 40 ]. arrhythmogenic right ventricular (ARVC) cardiomyocyte cardiomyopathy dilated cardiomyopathy (DCM) heart failure hypertrophic cardiomyopathy (HCM) hypertrophy primary cardiomyopathy restrictive cardiomyopathy...
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Clin Sci (Lond) (2016) 130 (10): 747–759.
Published: 01 April 2016
... variability between patients and the dynamic nature of pregnancy hampers interpretation of smaller studies, but some facts are consistent. Gestational cardiac hypertrophy and a physical shift of the heart contribute to changes in the ECG. There are also electrical changes such as an increased heart rate...
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Clin Sci (Lond) (2014) 127 (7): 435–448.
Published: 17 June 2014
... of calcineurin expression in cardiac fibroblasts and reduce myocardial apoptosis through lowering of mitochondrial permeability in cardiomyocytes, finally achieving the goal of improving heart failure. apoptosis calcineurin fibrosis histamine H 2 receptor hypertrophy • Mast cell...
Includes: Supplementary data
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Clin Sci (Lond) (2010) 119 (11): 453–463.
Published: 17 August 2010
... (renin–angiotensin–aldosterone system) to exert its effects. In numerous genetically modified animal models, non-specific or organ-targeted ET-1 overexpression causes intense organ damage, especially hypertrophy and fibrosis, in the absence of haemodynamic changes, confirming a local activity of the ET...
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Clin Sci (Lond) (2010) 118 (2): 137–145.
Published: 19 October 2009
... in the process of hypertrophy. In the present study, we have investigated the relationship between GDF15 gene variants and left ventricular hypertrophy in human essential hypertension. A community-based hypertensive population sample of 1527 individuals (506 men and 1021 women) was genotyped for three GDF15...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
..., but the role of individual signalling proteins in the pathogenesis of various cardiovascular diseases is still being elucidated. In the present review, the role of the MAPKs ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase) and p38 MAPK in cardiac hypertrophy, cardiac remodelling after...
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Clin Sci (Lond) (2002) 103 (s2002): 148S–151S.
Published: 01 September 2002
... the influence of various agonists or physical stress that, in the long term, also lead to development of hypertrophy. Previously, we identified three different Cl - channel activities in neonatal rat cardiomyocytes: (i) Ca 2+ regulated, (ii) cAMP regulated (cystic fibrosis transmembrane conductance regulator Cl...
Articles
Clin Sci (Lond) (2002) 102 (4): 411–416.
Published: 04 March 2002
...Leong L. NG; Russell J. O'BRIEN; Bettina DEMME; Sonja JENNINGS Cardiotrophin-1 (CT-1) leads to a specific form of ventricular hypertrophy characterized by sarcomeres added in series, and has been reported to be elevated in heart failure. Previous competitive assays for CT-1 necessitate...
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Clin Sci (Lond) (2001) 101 (1): 79–85.
Published: 12 June 2001
...Jenny A. DEAGUE; Catherine M. WILSON; Leeanne E. GRIGG; Stephen B. HARRAP Left ventricular hypertrophy is an independent cardiovascular risk factor. In hypertensives, the pattern of hypertrophy is influenced by central haemodynamic characteristics. Central haemodynamics may also determine...
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Clin Sci (Lond) (1999) 97 (3): 377–383.
Published: 06 August 1999
... hypertrophy left ventricle M-mode, population 377Clinical Science (1999) 97, 377 383 (Printed in Great Britain) Discrepancies between echocardiographic measurements of left ventricular mass in a healthy adult population Jenny A. DEAGUE Catherine M. WILSON , Leeanne E. GRIGG and Stephen B. HARRAP...
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Clin Sci (Lond) (1996) 90 (6): 447–452.
Published: 01 June 1996
... ventricular tachycardia. 6. Myocardium distant from infarction in patients with ischaemic heart disease has a normal pattern of connexin43 gap junction distribution, but has a 47% reduction in gap junction surface area per unit cell volume, and a 30% reduction per cell. 7. In hypertrophied myocardium from...
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Clin Sci (Lond) (1992) 83 (5): 575–581.
Published: 01 November 1992
...Martin Muntzel; Thierry Hannedouche; Roberte Niesor; Laure-Helène Nöel; Jean-Claude Souberbielle; Bernard Lacour; Tilman Drüeke 1. To determine whether treatment with octreotide, a somatostatin analogue, may diminish or prevent long-term diabetic renal hypertrophy and nephropathy, uninephrectomized...
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Clin Sci (Lond) (1990) 79 (5): 523–530.
Published: 01 November 1990
... and in the WIS 75.1 ± 7.8 mmHg ( P < 0.001). 6. These data indicate the presence of marked vascular and cardiac hypertrophy in the SHR at a very early period in its development. Blood pressure is elevated and there is no overactivity of the renin system. We conclude that, at this time...
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Clin Sci (Lond) (1989) 77 (2): 205–211.
Published: 01 August 1989
... diameter of oesophageal veins caudal to the sclerosing site, but did not affect the media thickness. 6. The results suggest that, in oesophageal and mesen- teric veins, portal pressure is a primary determinant of media thickness but not of lumen diameter. Key words: contractility, hypertrophy, mesenteric...
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Clin Sci Mol Med (1976) 51 (6): 551–555.
Published: 01 December 1976
... and the Medical Research Society 1976 deoxyribonucleic acid diabetes hyperplasia hypertrophy kidney ribonucleic acid Clinical Science and Molecular Medicine (1976) 51, 551-555. Renal hypertrophy in streptozotocin-diabetic rats K. SEYER-HANSEN Second University Clinic of Internal Medicine...