.... The central nervous system (CNS) in general, and the hypothalamus in particular, are intricately involved in the development and maintenance of hypertension. Over the last several decades, the understanding of the brain's role in the development of hypertension has dramatically increased. This brief review...

... (AMPK) has been revealed as one of the key molecules modulating energy homoeostasis. Indeed, AMPK appears to be essential for translating nutritional and energy requirements into generation of an adequate neuronal response, particularly in two areas of the brain, the hypothalamus and the hindbrain...

...Priya Sumithran; Joseph Proietto Although weight loss can usually be achieved by restricting food intake, the majority of dieters regain weight over the long-term. In the hypothalamus, hormonal signals from the gastrointestinal tract, adipose tissue and other peripheral sites are integrated...

.... In addition, alteration of AMPK signalling in the hypothalamus, which may function as a sensor of nutrient availability, integrating multiple nutritional and hormonal signals, may have a key role in the appearance of the MS. AMP-dependent kinase (AMPK) fatty acid oxidation hypothalamus lipid metabolic...

... balance, whereas adiponectin and resistin exert opposing effects on glucose and lipids. Understanding the actions of adipocyte hormones will provide novel insights into the pathophysiology and treatment of obesity. adiponectin adipose tissue hypothalamus leptin neuropeptide resistin Leptin...

... glutamatergic receptors hypothalamus Long Evans rats posterior pituitary supraoptic nucleus vasopressin 162S Clinical Science (2002) 103 (Suppl. 48), 162S 166S (Printed in Great Britain) Modulation of ETB receptor-induced arginine- vasopressin secretion by N-methyl-D-aspartate (NMDA) and c-aminobutyric...

... hypo- thalamic and extrahypothalamic sites, including the perifornical hypothalamus, the PVN and other medial hypothalamic nuclei [7]. Several studies have shown that NPY stimulates insulin release when injected into the third cerebral ventricle or into the NTS [8-11]. If animals are not allowed...

... by this sequence may therefore play an important role in the maintenance of vascular tone. 5 7 1993 21 7 1993 © 1993 The Biochemical Society and the Medical Research Society 1993 amylin calcitonin calcitonin-gene-related peptide hypothalamus islet amyloid polypeptide lung receptor...

... explain the decreased febrile responses observed. 6 3 1991 21 3 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 fever hypothalamus prostaglandin E 2 ChicalScience(l991) 81, 313-317 313 Effect of age on hypothalamic prostaglandin E, production...

... any peptide differences between obese and lean rats might be due to the overweight condition per se , separate groups of obese rats were food-restricted to reduce their body weight to lean values. 2. Concentrations of neuromedin B, a bombesin-like peptide, in the central hypothalamus were...

... 1990 2 8 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 gastric mucosal injury 5-hydroxytryptamine hypothalamus vagal adrenergic stimulation vasoconstriction Clinical Science (1991) 80,59-64 59 Mechanism of reserpine-induced acute gastric mucosal...

... females with methimazole in the drinking water. In two groups goitrpgen treatment continued for 3 or 10 weeks postnatally. 3. Methimazole treatment in utero did not produce significant changes in noradrenaline, dopamine or tyrosine content in either the hypothalamus or striatum. 4. Three weeks' postnatal...

.... These observations lend support to the hypothesis that sodium and the sympathetic nervous system have synergistic effects in the pathogenesis of hypertension in the SHR. © 1982 The Biochemical Society and the Medical Research Society 1982 central noradrenergic activity hypothalamus noradrenaline sodium...

...- chiasmatic nuclei in the regulation of salt and water balance. Key words: brain lesions, hypothalamus, salt hypertension, sodium metabolism. Correspondence: Dr Silvia Azar, University of Minnesota Hospitals, Box 112, Mayo Memorial Building, 420 Delaware St. S.E., Minneapolis, Min- nesota 55455, USA...

...I. Kobrin; R. Ebstein; D. Ben-Ishay 1. The noradrenaline-induced accumulation of cyclic AMP is decreased in both the anterior and the posterior hypothalamus of hypertension-prone as compared with resistant rats, but is similar in the cortex. 2. The nonadrenaline-induced accumulation of cyclic AMP...

...M. M. Kilcoyne; D. L. Hoffman; E. A. Zimmerman 1. By immunoperoxidase technique, immunoreactive angiotensin II (ANG II) was located in the cell bodies of many magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus and their pathways to median eminence and posterior...

.... © 1980 The Biochemical Society and the Medical Research Society 1980 haemodynamics hypothalamus obesity plasma volume Clinical Science (1980) 59,397s-399s 397s Haemodynamic changes associated with obesity and high blood pressure in rats with ventromedial hypothalamic lesions E. R E I S I...

... hypothalamic noradrenaline and lower adrenaline than resistant rats. 3. In response to a high salt diet brain-stem noradrenaline increased in sensitive rats and resistant rats exhibited a decrease on the same diet. Key words: brain stem, catecholamines, hypothalamus, salt sensitivity. Introduction Dahl salt...

...G. Stock; H. Stumpf; K. H. Schlör 1. Stimulation of the central amygdala, posterolateral hypothalamus and locus coeruleus in cats resulted in a sustained increase in arterial pressure, an increase in heart rate, with a poststimulation bradycardia and an increase in peripheral resistance...

... to adult levels. Peak numbers of receptors were up to 10 times the adult numbers. 3. The midbrain and thalamus-hypothalamus had maximum numbers of angiotensin II receptors at 2 weeks of age, whereas the rest of the brain regions had maximum numbers at 1 week. 4. Saralasin-infusion experiments suggested...

...M. Iijima; Y. Kitamura; N. Yamamoto; H. Kawamura; T. Yasugi; M. Hatano 1. Intravenous administration of angiotensin II reduced the adrenaline content, increased the catechol- O -methyltransferase activity, and decreased the monoamine oxidase activity of the rat hypothalamus. 2. Intraventricularly...

...H. Struyker Boudier; G. Smeets; G. Brouwer; J. Van Rossum 1. Various drugs were injected stereotactically into the brain of anaesthetized rats. 2. Noradrenaline injected into the area of the nucleus of the tractus solitarius in the lower brain stem or into the far anterior hypothalamus/pre-optic...

.... The pathological significance of the neural control of renin release has been discussed. © 1975 The Biochemical Society and the Medical Research Society 1975 aortic stenosis diuretics hypothalamus orthostasis renin sympathetic system Clinical Science and Molecular Medicine (1975) 48,215s-223s...

...A. Philippu 1. Cats were anaesthetized with pentobarbitone sodium. The hypothalamus was superfused with drugs through a push-pull cannula and electrically stimulated with the non-insulated tip of the cannula. In another series of experiments, the hypothalamus was stimulated with a monopolar...