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Keywords: hypoxia inducible factor 1α
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Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model

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Adriana L. Burgueño, Tomas F. Gianotti, Noelia G. Mansilla, Carlos J. Pirola, Silvia Sookoian
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (1): 53–63.
https://doi.org/10.1042/CS20120151
Published: 07 September 2012
... into the molecular events underlying the association between liver enzymes and CVD, we developed an HFD (high-fat diet)-induced NAFLD in the SHR (spontaneously hypertensive rat) and its control WKY (Wistar–Kyoto) rat strain. We hypothesized that hepatic induction of Hif1a (hypoxia-inducible factor 1α) might...
View article titled, Cardiovascular disease is associated with high-fat-diet-induced liver damage and up-regulation of the hepatic expression of hypoxia-inducible factor 1α in a rat model
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Includes: Supplementary data