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Keywords: imatinib
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Clin Sci (Lond) (2010) 118 (4): 241–247.
Published: 09 November 2009
...Dariush Mokhtari; Nils Welsh Altered tyrosine kinase signalling has been implicated in several diseases, paving the way for the development of small-molecule TKIs (tyrosine kinase inhibitors). TKIs such as imatinib, sunitinib and dasatinib are clinically used for treating chronic myeloid leukaemia...
Clin Sci (Lond) (2006) 111 (4): 233–249.
Published: 13 September 2006
..., is of major importance in the development of many haematological malignancies. An understanding of the mechanisms by which BCR - ABL contributes to the pathogenesis of chronic myeloid leukaemia led to the development of imatinib, the first of several tyrosine kinase inhibitors to enter clinical trials...