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Keywords: imatinib mesylate
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Articles

Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells

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Rikard G. Fred, Santosh Kumar Boddeti, Marcus Lundberg, Nils Welsh
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (1): 17–28.
https://doi.org/10.1042/CS20130560
Published: 27 August 2014
... Biochemical Society 2015 • Imatinib mesylate could be used in the treatment of diabetes, but the mechanisms by which it promotes its effects are not characterized. • We have observed in the present study that imatinib, besides inhibiting PDGFR-induced LRP1 phosphorylation, also increases...
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Articles

Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

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Robert Hägerkvist, Leif Jansson, Nils Welsh
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (1): 65–71.
https://doi.org/10.1042/CS20070122
Published: 30 November 2007
... disposal rates were calculated using Steeles equation [ 16 ]. © The Authors Journal compilation © 2008 Biochemical Society 2008 glucose disposal high-fat diet imatinib mesylate insulin sensitivity Type 2 diabetes Imatinib mesylate, also known as Gleevec or STI571, is a selective...
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