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Keywords: immune response
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Clin Sci (Lond) (2023) 137 (9): 707–725.
Published: 05 May 2023
... activation can result in tissue injury and can paradoxically render the host more vulnerable to subsequent infection, especially if the inflammatory state is both severe and prolonged [ 4 , 24 , 25 ]. hormones immune response mitochondria organ dysfunction sepsis stress response Sepsis...
Clin Sci (Lond) (2022) 136 (8): 521–535.
Published: 21 April 2022
... by Portland Press Limited on behalf of the Biochemical Society 2022 Colorectal cancer immune response molecular mechanisms Tumour budding Colorectal cancer (CRC) is the third most diagnosed cancer and the second most lethal malignancy worldwide [ 1 ]. A high level of heterogeneity...
Clin Sci (Lond) (2017) 131 (14): 1713–1721.
Published: 30 June 2017
... hyperresponsiveness (AHR) and inflammation are triggered following hMPV infection, and hMPV is able to persist in vivo by inhibiting innate immune responses and causing aberrant adaptive responses. In this review, we discuss the prevalence of hMPV infection in pediatric and adult populations and its potential role...
Clin Sci (Lond) (2015) 129 (5): 395–404.
Published: 11 June 2015
... is involved in HBV-related cellular immune responses. Cluster of differentiation (CD)4 + T-cells from peripheral blood were derived from healthy volunteers, resolved HBV individuals and chronic active hepatitis B patients and stimulated with CD3/28-conjugated beads. We analysed mRNA and protein levels of IL...
Clin Sci (Lond) (2012) 122 (4): 143–159.
Published: 14 October 2011
...Masahiko Mihara; Misato Hashizume; Hiroto Yoshida; Miho Suzuki; Masashi Shiina IL (interleukin)-6, which was originally identified as a B-cell differentiation factor, is a multifunctional cytokine that regulates the immune response, haemopoiesis, the acute phase response and inflammation. IL-6...
Clin Sci (Lond) (2007) 113 (2): 65–77.
Published: 13 June 2007
...Thais Martins de Lima; Renata Gorjão; Elaine Hatanaka; Maria Fernanda Cury-Boaventura; Erica Paula Portioli Silva; Joaquim Procopio; Rui Curi Fatty acids (FAs) have been shown to alter leucocyte function and thus to modulate inflammatory and immune responses. In this review, the effects of FAs...
Clin Sci (Lond) (2007) 112 (3): 141–155.
Published: 03 January 2007
... interact with several pathways in the host's immune response and disrupt pathogen-associated pattern recognition pathways, interfere with cellular immunoregulation via CD81 binding and subvert the activity of NK (natural killer) cells as well as CD4 + and CD8 + T-cells. Finally, HCV-specific T-cells become...
Clin Sci (Lond) (2006) 111 (2): 93–106.
Published: 13 July 2006
... anticancer immune responses, very few have reached mainstream clinical use. A new approach introduced over the last few years is to use immunostimulatory mAbs (monoclonal antibodies) to boost weak endogenous antitumour immune responses to levels which are therapeutic. Such agonistic or antagonistic mAbs bind...
Includes: Supplementary data
Clin Sci (Lond) (2006) 110 (3): 305–314.
Published: 10 February 2006
... is associated with increased risk for the development of peptic ulcer disease, gastric adenocarcinoma and gastric lymphoma. The development of a sustained gastric inflammatory and immune response to infection appears to be pivotal for the development of disease. During its long co-existence with humans, H...
Clin Sci (Lond) (2000) 98 (1): 71–79.
Published: 23 November 1999
... of pathology on the changes associated with knee surgery. Factor analysis provided a useful summary of the data. arthroplasty catecholamines cortisol cytokines hormones immune response surgery Correspondence: Dr G. M. Hall (e-mail g.hall@sghms.ac.uk ). 10 5 1999 11 8 1999 21...