... therapies. Inflammation has emerged as a potential contributor to the pathogenesis of HFpEF. Many of the risk factors for HFpEF are also associated with chronic inflammation, such as obesity, hypertension, aging, and renal dysfunction. A large amount of preclinical evidence suggests that immune cells...

...Bethany L. Goodlett; Dakshnapriya Balasubbramanian; Shobana Navaneethabalakrishnan; Sydney E. Love; Emily M. Luera; Sunitha Konatham; Valorie L. Chiasson; Sophie Wedgeworth; Joseph M. Rutkowski; Brett M. Mitchell Background: Hypertension (HTN) is associated with renal proinflammatory immune cell...

... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...

... (LT), and/or death. From a pathogenic point of view, exhaustion of drug metabolizing pathways, cell death mechanisms, activation of local immune cells, such as Kupffer cells, and recruitment of inflammatory leukocytes including monocytes and lymphocytes are key drivers of DILI progression. Taking...

... of both maternal and fetal morbidity and mortality, and there are no effective clinical treatments for pre-eclampsia aside from delivery. The development of pre-eclampsia is characterized by maladaptation of the maternal immune system, excessive inflammation and endothelial dysfunction. We have reported...

... 24 3 2015 • Cytokines drive the initiation and progression of the tissue-damaging immune response in IBDs (inflammatory bowel diseases), and are the prime therapeutic targets for these debilitating diseases. • IL (interleukin)-34, a cytokine produced by many cell types, is highly...

...Daniel Grimm; Maximilian Heeg; Robert Thimme Owing to the major limitations of current antiviral therapies in HBV (hepatitis B virus) infection, there is a strong need for novel therapeutic approaches to this major health burden. Stimulation of the host's innate and adaptive immune responses...

... proteases with many physiological functions beyond incretin degradation, including effects on the endocrine and immune systems. The role of DPP-4 on the immune system relates to its extra-enzymatic activities. The intracytosolic enzymes DPP-8 and DPP-9 are recently discovered DPP-4 family members. Although...

... mutations in the cellular genome. Cancers usually arise in individuals who fail to resolve their infection and who retain oncogene expression for years or decades. In most individuals, immune regression eventually leads to clearance of the virus, or to its maintenance in a latent or asymptomatic state...

...H. T. Cook; V. Cattell © 1996 The Biochemical Society and the Medical Research Society 1996 immune complex diseases immunity inflammation mediators nitric oxide nitric oxide synthase Clinical Science (1996) 91, 37M84 (Printed in Great Britain) Editorial Review 375 Role of nitric...