...: 826–32) were examined. The optimum pH of the enzymic activity against human angiotensinogen was 5.5 for both plasma and renal human renin in the hRN8-12 mice. Plasma concentrations of human active and inactive renin in the plasma of hRN8-12 mice were 16.7 ± 2.8 and 79.9 ± 14.0 pmol of angiotensin 1 h...

...Arne Høj Nielsen; Arne Johannessen; Knud Poulsen 1. The plasma concentration of inactive renin was two-to three-fold higher in male than in female mice independently of whether mice of strains with low (BALB/c) or high (Theiller) content of active renin in the submandibular salivary glands were...

...Yoichi Imamura; Kunio Hiwada; Tatsuo Kokubu 1. We separated inactive renin in human plasma into two types, adsorbed and non-adsorbed, by chromatography on a concanavalin A-Sepharose column. About 75% of fresh plasma inactive renin was adsorbed to the column, and the rest passed through it. Non...

... sodium intake. 2. Whether inactive renin was activated by acid or trypsin, it tended to be increased by 50–100% in unilateral renal ischaemia patients compared with essential hypertension. Active renin was increased two- to four-fold in unilateral renal ischaemia patients compared with those...

...Robert C. Franks; Francis Bodola; Robert D. Renthal; Robert H. Hayashi 1. Inactive renin was isolated from human amniotic fluid by chromatography with DEAE-cellulose, pepstatin-aminobutyl-agarose, octylagarose and Cibacron Blue F3GA columns. 2. Before and after isolation from amniotic fluid...

...M. H. De Keijzer; A. P. Provoost; F. H. M. Derkx 1. Rat plasma was subjected at 4°C to various treatments known to convert inactive renin into its active form in human plasma. 2. No statistical differences in plasma renin concentration were found when the levels after the various treatments were...

...H. K. Richards; A. R. Noble; K. A. Munday 1. The effect of the β-adrenoceptor agonist isoprenaline on the secretion of active and inactive renin was investigated in two preparations. 2. in ten urethane-anaesthetized rabbits isoprenaline, given as a renal artery infusion, had relatively minor...

... in an active form. Clinical Science (1980) 59,35~-36s 35s Active and inactive renin in individual juxtaglomerular apparatuses A. G I L L I E S , T . M O R G A N A N D W. F I T Z G I B B O N Faculty of Medicine, University of Newcastle. N S . W., Australia Summary Methods 1. Renin was measured in individual...

...A. M. Kappelgaard; J. Giese; H. Ibsen; M. Damkjær Nielsen; A. Rabøl 1. In plasma samples from normal subjects and patients with untreated essential hypertension, the concentration of inactive renin (as measured after acidification) was on average 4–5 times higher than the concentration of active...

... and decreased by indomethacin. The latter also blunted the increase of active renin after stimuli. 3. Inactive renin was slightly increased by orthostasis, but was not significantly influenced by acute administration of frusemide or inhibition of prostaglandin synthesis by indomethacin. 4. The results show...

...Brenda Leckie; J. J. Brown; R. Fraser; K. Kyle; A. F. Lever; J. J. Morton; J. I. S. Robertson 1. A patient presented with mild hypertension, a raised plasma total renin concentration but a normal plasma angiotensin II concentration. The discrepancy was due to a high concentration of inactive renin...

... to some of the plasma protease inhibitors; q-macroglobulin, inter-a-trypsin inhibitor and G- antithrombin. It was also bound to a,- and &lipo- protein, albumin and an unidentified plasma pro- tein. No binding was seen to more than 50 other studied plasma proteins. Key words: inactive renin, protease...

...F. H. M. Derkx; R. P. Verhoeven; G. J. Wenting; A. J. Man in 't Veld; M. A. D. H. Schalekamp 1. Active and acid-activable inactive renin were measured in renal venous and arterial plasma of 18 patients with essential hypertension (EHT) and 19 patients with renovascular hypertension (RVHT). In seven...

...B. J. Leckie 1. The protease inhibitors Trasylol and soya-bean trypsin inhibitor prevented the activation of plasma inactive renin by acid. 2. N -Ethylmaleimide inhibited acid-activation to some extent but o -phenanthroline had no effect. 3. Acid-activation of the inactive renin in human plasma...

... acid activation cryoactivation inactive renin neutral serine proteases protease inhibitors Clinical Science and Molecular Medicine (1978) 55,135s-138s Activation of inactive plasma renin: evidence that both cryoactivation and acid-activation work by liberating a neutral serine protease from...