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1-8 of 8
Keywords: inflammasome
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (5): 333–351.
Published: 01 March 2023
... will focus on the role of NACHT, leucin-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome in the pathophysiology of sepsis. NLRP3 inflammasome is a multiproteic intracellular complex activated by infectious pathogens through a two-step process resulting in the release of the pro-inflammatory...
Articles
Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...
Articles
Danlin Liu, Gavin Richardson, Fehmi M. Benli, Catherine Park, João V. de Souza, Agnieszka K. Bronowska, Ioakim Spyridopoulos
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
.... The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD + metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (20): 2221–2239.
Published: 29 October 2018
...Cheng-Yi Chen; Chia-Yu Chen; Chang-Ching Liu; Chie-Pein Chen Preterm labor is associated with inflammation and infection. The mechanisms underlying the role of omega-3 fatty acid in inflammasome activation and prevention of preterm labor remain unknown. We hypothesized that omega-3 fatty acid can...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1901–1924.
Published: 05 September 2018
...) pyrin domain containing 3 (NLRP3), and the consequence of NF-κB dysfunction on inflammasome activation cannot be discounted. Key players in the regulation of NF-κB are also implicated in the regulation of NLRP3, as seen with A20 and the possible role of inflammasome activation in the inflammatory...
Articles
Stacy Robertson, Gonzalo J. Martínez, Cloe A. Payet, Jennifer Y. Barraclough, David S. Celermajer, Christina Bursill, Sanjay Patel
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1237–1246.
Published: 13 June 2016
...Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis...
Includes: Supplementary data
Articles
Mark R. Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N. Karmali, S. Ramani Moonesinghe, Fares S. Haddad, Michael G. Mythen, Mervyn Singer, Gareth L. Ackland
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... apoptosis induced by a range of common stressors. Glucocorticoids, which are ubiquitously elevated for a prolonged period postoperatively, generated increased levels of mitochondrial reactive oxygen species, activated caspase-1 and mature interleukin (IL)-1β in human lymphocytes, suggesting inflammasome...
Includes: Supplementary data
Articles
Geena Varghese Paramel, Lasse Folkersen, Rona J. Strawbridge, Ali Ateia Elmabsout, Eva Särndahl, Pia Lundman, Jan-Håkan Jansson, Göran K. Hansson, Allan Sirsjö, Karin Fransén
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (8): 401–407.
Published: 14 June 2013
... the inflammasome, a molecular machine that produces IL (interleukin)-1β in response to cholesterol crystal accumulation in macrophages. The CARD8 (caspase recruitment domain 8) protein modulates this process by suppressing caspase 1 and the transcription factor NF-κB (nuclear factor κB). The expression of CARD8...