... will focus on the role of NACHT, leucin-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome in the pathophysiology of sepsis. NLRP3 inflammasome is a multiproteic intracellular complex activated by infectious pathogens through a two-step process resulting in the release of the pro-inflammatory...

.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...

.... The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD + metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging...

...Cheng-Yi Chen; Chia-Yu Chen; Chang-Ching Liu; Chie-Pein Chen Preterm labor is associated with inflammation and infection. The mechanisms underlying the role of omega-3 fatty acid in inflammasome activation and prevention of preterm labor remain unknown. We hypothesized that omega-3 fatty acid can...

... research. Evaluation of the major cytokine/s involved in monogenic autoinflammatory disorders may point to distinctions between conditions within the same pathway. The gain of function mutations in inflammasome forming proteins that lead to disease can be presumed to cause an increase in IL-1β processing...

...Stacy Robertson; Gonzalo J. Martínez; Cloe A. Payet; Jennifer Y. Barraclough; David S. Celermajer; Christina Bursill; Sanjay Patel Inflammasome activation, with subsequent release of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, has recently been implicated in atherosclerosis...

... apoptosis induced by a range of common stressors. Glucocorticoids, which are ubiquitously elevated for a prolonged period postoperatively, generated increased levels of mitochondrial reactive oxygen species, activated caspase-1 and mature interleukin (IL)-1β in human lymphocytes, suggesting inflammasome...

... the inflammasome, a molecular machine that produces IL (interleukin)-1β in response to cholesterol crystal accumulation in macrophages. The CARD8 (caspase recruitment domain 8) protein modulates this process by suppressing caspase 1 and the transcription factor NF-κB (nuclear factor κB). The expression of CARD8...