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Keywords: inflammasome
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Articles
Clin Sci (Lond) (2023) 137 (5): 333–351.
Published: 01 March 2023
... will focus on the role of NACHT, leucin-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome in the pathophysiology of sepsis. NLRP3 inflammasome is a multiproteic intracellular complex activated by infectious pathogens through a two-step process resulting in the release of the pro-inflammatory...
Articles
Articles
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
.... The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD + metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging...
Articles
Clin Sci (Lond) (2018) 132 (20): 2221–2239.
Published: 29 October 2018
...Cheng-Yi Chen; Chia-Yu Chen; Chang-Ching Liu; Chie-Pein Chen Preterm labor is associated with inflammation and infection. The mechanisms underlying the role of omega-3 fatty acid in inflammasome activation and prevention of preterm labor remain unknown. We hypothesized that omega-3 fatty acid can...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (17): 1901–1924.
Published: 05 September 2018
...) pyrin domain containing 3 (NLRP3), and the consequence of NF-κB dysfunction on inflammasome activation cannot be discounted. Key players in the regulation of NF-κB are also implicated in the regulation of NLRP3, as seen with A20 and the possible role of inflammasome activation in the inflammatory...
Articles
Articles
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
... apoptosis induced by a range of common stressors. Glucocorticoids, which are ubiquitously elevated for a prolonged period postoperatively, generated increased levels of mitochondrial reactive oxygen species, activated caspase-1 and mature interleukin (IL)-1β in human lymphocytes, suggesting inflammasome...
Includes: Supplementary data
Articles