...Yan Tang; Yao Shi; Yifei Gao; Xiaomeng Xu; Ting Han; Jingxin Li; Chuanyong Liu Inflammatory bowel disease (IBD) is a chronic intestinal inflammation, but the accurate etiology remains to be elucidated. Increasing evidence has shown that macrophages polarize to different phenotypes depending...

...Katharine G. Harris; Eugene B. Chang Inflammatory bowel diseases (IBD) are a group of chronic diseases of increasing worldwide prevalence characterized by gastrointestinal (GI) inflammation leading to debilitating symptoms and complications. The contribution of the intestinal microbiota...

... in colitic mice through an AMP-activated protein kinase-independent mechanism. Expression of active form of AMP-activated protein kinase was reduced in inflammatory bowel disease patients and treatment of mucosal cells of such patients with metformin enhanced AMP-activated protein kinase activation...

... inflammation inflammatory bowel disease Cardiotrophin-1 (CT-1) is a 21.5-kDa member of the IL-6 family of cytokines that was named after its ability to stimulate the growth of cultured cardiac myocytes [ 1 ]. CT-1 acts by binding to a specific receptor complex containing gp130 and leukemia inhibitory...

... in this tissue include homoeostatic regulation of intestinal cell proliferation/differentiation and modulation of inflammation associated with inflammatory bowel disease and colon cancer. Analysis of mouse epithelial cells in the intestine and colon has clearly demonstrated that ligand activation of PPARβ/δ...

... or beneficial to one without disadvantage to the other. Animal model and clinical studies suggest that IBD (inflammatory bowel disease) may develop in a susceptible individual when the normal host–bacterial relationship is dysregulated. In addition to rodent models, this article reviews studies that have...

...Mimoun EL YOUSFI; Denis BREUILLÉ; Isabelle PAPET; Stéphanie BLUM; Marc ANDRÉ; Laurent MOSONI; Philippe DENIS; Caroline BUFFIÈRE; Christiane OBLED Inflammatory bowel diseases (IBDs) are associated with an increased whole-body protein turnover. In certain drug-induced experimental models of IBD...

...S. P. PEREIRA; J. M. RHODES; B. J. CAMPBELL; D. KUMAR; I. M. BAIN; G. M. MURPHY; R. H. DOWLING 1. One hypothesis for the link between inflammatory bowel disease and primary sclerosing cholangitis is that neutrophil activators, such as bacterial chemotactic peptides or neutrophil granule products...

.... Hyperleptinaemia may mediate the anorexia and weight loss which is observed in chronic infections and inflammatory conditions. 2. Plasma leptin and soluble tumour necrosis factor receptor (sTNF-r55) concentrations were measured in patients with inflammatory bowel disease and acquired immunodeficiency syndrome...

...-dependent diabetes mellitus and Graves' disease. 3. Genome screens have also been completed in some of the non-organ-specific autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease and psoriasis. Many candidate genes have also been investigated although these are predominantly...

... synthesis de novo and the first step in platelet-activating factor degradation have been investigated for the first time in incubates of normal human colon mucosa and in inflamed mucosa from patients with inflammatory bowel disease. 3. In the presence of 100 μmol/l CDP-choline and 100 μmol/l hexadecyl...

...S. M. Greenfield; A. Hamblin; N. A. Punchard; R. P. H. Thompson 1. The expression of leucocyte antigens CD11/CD18 and complement receptor 1 was studied on the circulating leucocytes of 13 patients with inflammatory bowel disease and 13 age- and sex-matched healthy control subjects. 2. Monoclonal...

...Y. R. Mahida; M. Ceska; F. Effenberger; L. Kurlak; I. Lindley; C. J. Hawkey 1. We studied neutrophil-activating peptide-1/interleukin-8 in inflammatory bowel disease. 2. Mucosal levels of neutrophil-activating peptide-1/ interleukin-8 were significantly higher in patients with active ulcerative...

...S. J. S. Ryde; D. Clements; W. D. Evans; R. Motley; W. D. Morgan; C. Evans; J. Rhodes; J. E. Compston 1. Serial measurements of total body calcium have been made by prompt γ-neutron activation analysis in 13 patients with inflammatory bowel disease over a mean period of 23 months. Changes in spinal...

... Crohn's disease inflammatory bowel disease ulcerative colitis zinc Clinical Science (1988) 75,277-283 277 Zinc status in inflammatory bowel disease C. C. AINLEY, J. CASON, L. K. CARLSSON, B. M. SLAVIN AND R. P. H. THOMPSON Gastrointestinal Laboratory, The Rayne Institute, and Department of Chemical...

... in inflammatory bowel disease. The ratios of oleic acid to stearic acid and to palmitic acid were lower in inflammatory bowel disease. 4. The alteration in the fatty acid profile may partly explain the increased synthesis of eicosanoids in colonic mucosa in inflammatory bowel disease. 4 3 1987 27 3...