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Keywords: innate immunity
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Clin Sci (Lond) (2023) 137 (5): 333–351.
Published: 01 March 2023
.... Correspondence: Fabienne Venet ( fabienne.venet@chu-lyon.fr ) 21 11 2022 15 02 2023 16 02 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 adaptive immunity inflammasome innate immunity NLRP3 SARS-Co-V2 sepsis...
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Clin Sci (Lond) (2020) 134 (19): 2645–2664.
Published: 16 October 2020
... of the experimental data is associated with weak clinical long-term studies of the existence of a similar regulation of tissue or plasma ACE2 in human subjects. angiotensin II angiotensin-(1-7) cardiovascular disease coronavirus chymase innate immunity Since December 2019, coronavirus disease 2019...
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Clin Sci (Lond) (2019) 133 (14): 1549–1565.
Published: 17 July 2019
...Jan Černý; Ilja Stříž The innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of ‘privileged’ adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes ‘steal the show...
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Clin Sci (Lond) (2017) 131 (16): 2183–2199.
Published: 31 July 2017
... Society 2017 diabetic nephropathy inflammation innate immunity Diabetic nephropathy is the most prevalent chronic kidney disease and is the major cause of end-stage renal disease (ESRD) worldwide. This is predominantly due to the growing incidence of Type 2 diabetes associated with obesity...
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Clin Sci (Lond) (2017) 131 (16): 2145–2159.
Published: 24 July 2017
.... bone marrow macrophages inflammation innate immunity non alcoholic fatty liver disease necroptosis Toll-like receptors Among patients with non-alcoholic fatty liver disease (NAFLD), adverse liver outcomes are confined to those (10–25%) with steatohepatitis (non-alcoholic steatohepatitis...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (4): 269–283.
Published: 20 January 2017
... components. The innate immune response provides the first line of defence and is crucial to the outcome of infection. Airway epithelial cells are the first cell type to encounter the virus in the lungs, providing antiviral and chemotactic molecules that shape the ensuing immune response by rapidly recruiting...
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Clin Sci (Lond) (2011) 120 (10): 441–450.
Published: 28 January 2011
...Alessandro Lambiase; Alessandra Micera; Marta Sacchetti; Flavio Mantelli; Stefano Bonini The ocular surface is the first line of defence in the eye against environmental microbes. The ocular innate immune system consists of a combination of anatomical, mechanical and immunological defence...
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Clin Sci (Lond) (2009) 116 (6): 479–492.
Published: 12 February 2009
.... In spite of our greater understanding of this complication, the intimate mechanisms leading to the development and progression of renal injury are not well understood. New perspectives in activated innate immunity and inflammation appear to be relevant factors in the pathogenesis of diabetes. Moreover...
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Clin Sci (Lond) (2008) 114 (7): 457–466.
Published: 29 February 2008
...Mark G. Swain The innate immune system represents a critical first line of host response to infectious, injurious and inflammatory insults. NKT cells (natural killer T-cells) are an important, but relatively poorly understood, component of the innate immune response. Moreover, NKT cells...
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Clin Sci (Lond) (2008) 114 (5): 347–360.
Published: 01 February 2008
...E. Ann Misch; Thomas R. Hawn Although several lines of evidence suggest that variation in human inflammation is genetically controlled, the genes which regulate these responses are largely unknown. TLRs (Toll-like receptors) mediate recognition of microbes, regulate activation of the innate immune...
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Clin Sci (Lond) (2006) 110 (1): 21–35.
Published: 12 December 2005
... functioning of the innate immune system, and may have further importance in the integration of this system with the adaptive immune response. Recent interest has focused on the influence of inflamed tissues on the recruitment and phenotypic modulation of cells of the adaptive immune system and, indeed...