.... Correspondence: Fabienne Venet ( [email protected] ) 21 11 2022 15 02 2023 16 02 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 adaptive immunity inflammasome innate immunity NLRP3 SARS-Co-V2 sepsis...

... fatality rates in males outstripping that of females by nearly two-fold. This male sex-specific predilection in COVID-19-related mortality is deemed to be multifold (e.g. higher rates of tobacco smoking and alcohol consumption; sex-driven innate immunity differences). As reviewed by us [ 18 ] the mapping...

... diabetes inflammation innate immunity neutrophil elastase Type 1 diabetes is one of the most frequent and life-debilitating autoimmune disorders caused by the selective destruction of the insulin-producing β cells located in pancreatic Langerhans’ islets [ 1 ]. Although the incidence of Type 1...

...Jan Černý; Ilja Stříž The innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of ‘privileged’ adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes ‘steal the show...

... a common structure and mechanism of toxicity of SPOs regardless of their native protein, it is reasonable to speculate that SPOs contribute to sepsis pathogenesis by promoting inflammation through FPR signaling and activation of the innate immune system as has been shown in AD [ 23 ]. This hypothesis has...

... ]. Correspondence: Greg Tesch ( [email protected] ) 02 06 2017 04 07 2017 10 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 diabetic nephropathy inflammation innate immunity A large number of rat and mouse...

... innate immunity non alcoholic fatty liver disease necroptosis Toll-like receptors Among patients with non-alcoholic fatty liver disease (NAFLD), adverse liver outcomes are confined to those (10–25%) with steatohepatitis (non-alcoholic steatohepatitis, NASH) [ 1 ]. The essential difference...

...Piyali Chatterjee; Valorie L. Chiasson; Geetha Seerangan; Eugene De Guzman; Moheb Milad; Kelsey R. Bounds; Olga Gasheva; Richard P. Tobin; Mohamad Hatahet; Shelley Kopriva; Kathleen A. Jones; M. Karen Newell-Rogers; Brett M. Mitchell Excessive innate immune system activation and inflammation during...

... components. The innate immune response provides the first line of defence and is crucial to the outcome of infection. Airway epithelial cells are the first cell type to encounter the virus in the lungs, providing antiviral and chemotactic molecules that shape the ensuing immune response by rapidly recruiting...

... of innate immune cellular sources, intracellular IL-17A staining was performed. In the present study, we demonstrate that CS exposure primes natural killer (NK), natural killer T (NKT) and γδ T-cells to produce more IL-17A protein and CS alone increased the frequency of IL17 + γδ T-cells in the lung...

... the upper disc was glued to the mucosal side of the biopsy by histoacryl adhesive. A hallmark feature of aging is immunosenescence and the functional decline of the adaptive and innate immune system resulting in compromised immunity to microbial pathogens and increased frequency of cancer [ 1 , 2...

... contribute to adverse ventricular remodelling. Such inflammation is initiated by molecular danger signals released by damaged myocardium, which induce innate immune responses by activating toll-like receptors (TLRs). Detrimental roles have been recently reported for TLR2, TLR3 and TLR4. The role of other...

...Vincent P.W. Scholtes; Dik Versteeg; Jean-Paul P.M. de Vries; Imo E. Hoefer; Arjan H. Schoneveld; Pieter R. Stella; Pieter A.F.M. Doevendans; Karlijn J.K. van Keulen; Dominique P.V. de Kleijn; Frans L. Moll; Gerard Pasterkamp The innate immune response elicited by activation of TLRs (Toll-like...

...Alessandro Lambiase; Alessandra Micera; Marta Sacchetti; Flavio Mantelli; Stefano Bonini The ocular surface is the first line of defence in the eye against environmental microbes. The ocular innate immune system consists of a combination of anatomical, mechanical and immunological defence...

.... In spite of our greater understanding of this complication, the intimate mechanisms leading to the development and progression of renal injury are not well understood. New perspectives in activated innate immunity and inflammation appear to be relevant factors in the pathogenesis of diabetes. Moreover...

...Mark G. Swain The innate immune system represents a critical first line of host response to infectious, injurious and inflammatory insults. NKT cells (natural killer T-cells) are an important, but relatively poorly understood, component of the innate immune response. Moreover, NKT cells...

...E. Ann Misch; Thomas R. Hawn Although several lines of evidence suggest that variation in human inflammation is genetically controlled, the genes which regulate these responses are largely unknown. TLRs (Toll-like receptors) mediate recognition of microbes, regulate activation of the innate immune...

... functioning of the innate immune system, and may have further importance in the integration of this system with the adaptive immune response. Recent interest has focused on the influence of inflamed tissues on the recruitment and phenotypic modulation of cells of the adaptive immune system and, indeed...