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Keywords: insulin resistance
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Articles
Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Thiago Gomes Heck, Mauricio Krause, Paulo Ivo Homem de Bittencourt Jr.
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (02): 85–113.
Published: 23 January 2025
... insulin resistance and type-2 diabetes onset. A logistic model (five-parameter logistic) showed progressive HSR decline, with HFD mice exhibiting earlier ΔHSP70 reduction ( t 1/2 = 3.14 weeks) compared with NC mice ( t 1/2 = 8.24 weeks), highlighting compromised anti-inflammatory capacity in both groups...
Includes: Supplementary data
Articles
Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D 1 R expression
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1391–1407.
Published: 07 September 2023
...Yu Tao; Wenbin Luo; Yue Chen; Caiyu Chen; Shengnan Chen; Xiaoping Li; Ken Chen; Chunyu Zeng Exercise has been recommended as a nonpharmaceutical therapy to treat insulin resistance (IR). Previous studies showed that dopamine D 1 -like receptor agonists, such as fenoldopam, could improve peripheral...
Includes: Supplementary data
Articles
Soumyalekshmi Nair, Valeska Ormazabal, Flavio Carrion, Aase Handberg, H David McIntyre, Carlos Salomon
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1311–1332.
Published: 31 August 2023
...-mediated EV cross-talk serving as central components in GDM pathophysiology. This review focuses on the role of the placenta in the pathophysiology of GDM and explores the possibilities and prospects of targeting the placenta to address insulin resistance and placental dysfunction in GDM. Additionally, we...
Articles
Alena Karnošová, Veronika Strnadová, Blanka Železná, Jaroslav Kuneš, Petr Kašpárek, Lenka Maletínská
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (10): 847–862.
Published: 31 May 2023
.... In addition, reduced insulin pathway signaling proteins in NPFFR2 KO mice fed a HFD resulted in the development of hypothalamic insulin resistance. HFD feeding did not cause liver steatosis in NPFFR2 KO mice of either sex, but NPFFR2 KO male mice fed a HFD had lower body weights, white adipose tissues...
Includes: Supplementary data
Articles
In Collection
Reproductive Physiology and Disease
Laura B James-Allan, Frederick J Rosario, Lana Madi, Kelsey Barner, Soumyalekshmi Nair, Andrew Lai, Flavio Carrion, Theresa L Powell, Carlos Salomon, Thomas Jansson
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1535–1549.
Published: 03 November 2022
... agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. glucose homeostasis insulin resistance microparticles pancreatic beta cell Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset during pregnancy [ 1...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
Articles
James T. Pearson, Hamish P. Thambyah, Mark T. Waddingham, Tadakatsu Inagaki, Vijayakumar Sukumaran, Jennifer P. Ngo, Connie P.C. Ow, Takashi Sonobe, Yi Ching Chen, Amanda J. Edgley, Yutaka Fujii, Cheng-Kun Du, Dong-Yun Zhan, Keiji Umetani, Darren J. Kelly, Hirotsugu Tsuchimochi, Mikiyasu Shirai
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (2): 327–346.
Published: 22 January 2021
... A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation...
Includes: Supplementary data
Articles
In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
, Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
... leading to protection from pathological muscle remodelling and muscle insulin resistance. In contrast, there is relatively little evidence to support the protective role of ACE2 in skeletal muscle. The potential contribution of endogenous ACE2 to the regulation of Ang 1-7-mediated protection...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2789.
Published: 02 November 2020
... © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Green tea polyphenols insulin receptor substrate-1 insulin resistance obesity protein kinase C-θ Zucker fatty rats The Editorial Office has been made aware of potential issues...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2117–2135.
Published: 21 August 2020
...Frédéric Clarembeau; Georgia Bale; Nicolas Lanthier End-stage chronic liver diseases are often associated with insulin resistance (IR) and diabetes mellitus (DM). Indeed, to quantify insulin sensitivity the euglycemic clamp technique was utilized, allowing the following to be stated: in small...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1167–1180.
Published: 27 May 2020
...) levels. Homoeostasis model assessment of insulin resistance (HOMA-IR), a measure of insulin resistance, was lower ( P <0.01) in GTP-treated animals compared with ZF controls. Moreover, insulin-stimulated glucose uptake by isolated soleus muscle was increased ( P <0.05) in GTP-ZF rats compared...
Articles
In Collection
Clinical and translational research highlights
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (6): 571–592.
Published: 18 March 2020
... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects...
Includes: Supplementary data
Articles
Chayodom Maneechote, Siripong Palee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
...Chayodom Maneechote; Siripong Palee; Nattayaporn Apaijai; Sasiwan Kerdphoo; Thidarat Jaiwongkam; Siriporn C. Chattipakorn; Nipon Chattipakorn Obese insulin resistance impairs cardiac mitochondrial dynamics by increasing mitochondrial fission and decreasing mitochondrial fusion, leading...
Articles
Wei Cao, Meng Shi, Liling Wu, Jiaxin Li, Zhichen Yang, Youhua Liu, Christopher S. Wilcox, Fan Fan Hou
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... Adipose tissue High fat diet Insulin resistance Renin-angiotensin system Salt Sympathetic reflex Obesity is characterized by excessive accumulation of white adipose tissue due to an imbalance between food intake and energy expenditure [ 1 ]. People with obesity often have insulin resistance...
Includes: Supplementary data
Articles
Kenneth Verboven, Rudi Stinkens, Dominique Hansen, Inez Wens, Ines Frederix, Bert O. Eijnde, Johan W.E. Jocken, Gijs H. Goossens, Ellen E. Blaak
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1685–1698.
Published: 14 August 2018
... sensitive (IS) ( n =10), obese IS ( n =10), and obese insulin resistant (IR) ( n =10) men. Obese men participated in a 12-week exercise training intervention to determine the effects on SCAT lipolysis. Abdominal SCAT extracellular glycerol concentration and blood flow (ATBF) were investigated using...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (11): 1085–1095.
Published: 05 June 2018
... the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS). We...
Articles
Frank J. Ong, Basma A. Ahmed, Stephan M. Oreskovich, Denis P. Blondin, Tahniyah Haq, Norman B. Konyer, Michael D. Noseworthy, Francois Haman, Andre C. Carpentier, Katherine M. Morrison, Gregory R. Steinberg
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
Includes: Supplementary data
Articles
Eleni Rebelos, Brenno Astiarraga, Roberto Bizzotto, Andrea Mari, Maria Laura Manca, Alex Gonzalez, Armando Mendez, Claudia A. Martinez, Barry E. Hurwitz, Ele Ferrannini
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2901–2910.
Published: 04 December 2017
...Eleni Rebelos; Brenno Astiarraga; Roberto Bizzotto; Andrea Mari; Maria Laura Manca; Alex Gonzalez; Armando Mendez; Claudia A. Martinez; Barry E. Hurwitz; Ele Ferrannini Previous work has shown that potentiation of insulin release is impaired in non-diabetic insulin resistance; we tested...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (22): 2701–2704.
Published: 06 November 2017
...Amalia Gastaldelli Whether non-alcoholic fatty liver disease (NAFLD) precedes insulin resistance (IR) or IR preludes/causes NAFLD has been long debated. Recent studies have shown that there are two phenotypes of NAFLD, ‘genetic’ vs ‘metabolic’ NAFLD. The former patients are more at risk...
Articles
Bram Brouwers, Vera B. Schrauwen-Hinderling, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne Bruls, Dennis Dahlmans, Michael Roden, Matthijs K.C. Hesselink, Patrick Schrauwen
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1905–1917.
Published: 07 July 2017
...), hepatic insulin resistance index (HIR i ) ( r =0.576, P =0.001), and Δ R d ( r =−0.653, P <0.001) correlated with IHL content. Individuals with NAFL suffer from metabolic perturbations to a similar degree as T2DM patients. NAFL is an important feature leading to severe insulin resistance and should...
Articles
Yong Luo, Ling Li, Xiaohui Xu, Tong Wu, Mengliu Yang, Cheng Zhang, Huaming Mou, Tingting Zhou, Yanjun Jia, Chenrongrong Cai, Hua Liu, Gangyi Yang, Xianxiang Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (3): 239–246.
Published: 18 January 2017
... demonstrated the relationship of circulating BMP-9 levels with insulin resistance (IR) or Type 2 diabetes mellitus (T2DM) in humans. The objective of the present study was to investigate the relationship between BMP-9 and IR in cross-sectional and interventional studies. Circulating BMP-9 levels were analysed...
Includes: Supplementary data
Articles
Rikke Kruse, Andreas J.T. Pedersen, Jonas M. Kristensen, Stine J. Petersson, Jørgen F.P. Wojtaszewski, Kurt Højlund
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1603–1614.
Published: 08 August 2016
...Matthias Blüher The worldwide obesity epidemic has become a major health concern, because it contributes to higher mortality due to an increased risk for noncommunicable diseases including cardiovascular diseases, type 2 diabetes, musculoskeletal disorders and some cancers. Insulin resistance may...
Articles
Xia Kang, Along Hou, Rui Wang, Da Liu, Wei Xiang, Qingyun Xie, Bo Zhang, Lixia Gan, Wei Zheng, Hongming Miao
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1257–1268.
Published: 13 June 2016
... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...
Includes: Supplementary data
Articles
Daniel J. Cuthbertson, Fariba Shojaee-Moradie, Victoria S. Sprung, Helen Jones, Christopher J.A. Pugh, Paul Richardson, Graham J. Kemp, Mark Barrett, Nicola C. Jackson, E. Louise Thomas, Jimmy D. Bell, A. Margot Umpleby
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (2): 93–104.
Published: 09 December 2015
... (hepatic, skeletal muscle, adipose tissue) insulin resistance (IR). Exercise is an effective treatment for lowering liver fat but its effect on IR in NAFLD is unknown. We aimed to determine whether supervised exercise in NAFLD would reduce liver fat and improve hepatic and peripheral (skeletal muscle...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1083–1096.
Published: 13 October 2015
... inflammation, which also manifests within metabolic tissues such as adipose tissue and liver. This metabolic inflammation can promote insulin resistance and dysglycaemia. However, the obesity and metabolic disease-related immune responses that are compartmentalized in the intestinal environment do...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1025–1036.
Published: 18 September 2015
...Lina Zhao; Zhuo Fu; Jing Wu; Kevin W. Aylor; Eugene J. Barrett; Wenhong Cao; Zhenqi Liu Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance...
Articles
Tong-Yan Liu, Chang-Xiang Shi, Run Gao, Hai-Jian Sun, Xiao-Qing Xiong, Lei Ding, Qi Chen, Yue-Hua Li, Jue-Jin Wang, Yu-Ming Kang, Guo-Qing Zhu
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (10): 839–850.
Published: 19 August 2015
..., induces the browning of white adipose tissue, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of irisin on gluconeogenesis and glycogenesis in hepatocytes with insulin resistance, and its therapeutic role in type...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (5): 405–414.
Published: 11 June 2015
...Camilla Kappe; Liselotte Fransson; Petra Wolbert; Henrik Ortsäter Evidence indicates that subtle abnormalities in GC (glucocorticoid) plasma concentrations and/or in tissue sensitivity to GCs are important in the metabolic syndrome, and it is generally agreed that GCs induce insulin resistance...
Includes: Supplementary data
Articles
Mauricio Krause, Patricia Martins Bock, Hilton Kenji Takahashi, Paulo Ivo Homem De Bittencourt, Jr, Philip Newsholme
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 789–803.
Published: 19 March 2015
... (eHSP70) has a pro-inflammatory function, resulting in local and systemic inflammation. We have recently identified a divergence in the levels of eHSP70 and iHSP70 in subjects with diabetes compared with healthy subjects and also reported that eHSP70 was correlated with insulin resistance and pancreatic β...
Articles
Tomás Meroño, Fernando Brites, Carolane Dauteuille, Marie Lhomme, Martín Menafra, Alejandra Arteaga, Marcelo Castro, María Soledad Saez, Esteban González Ballerga, Patricia Sorroche, Jorge Rey, Philippe Lesnik, Juan Andrés Sordá, M. John Chapman, Anatol Kontush, Jorge Daruich
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (9): 609–618.
Published: 11 February 2015
... efflux and antioxidative activity) were studied. IO patients compared with controls exhibited insulin resistance (HOMA-IR (homoeostasis model assessment-estimated insulin resistance): +93%, P < 0.001). Metabolic profiles differed across HFE genotypes. C282Y homozygotes ( n =7) presented a reduced β...
Includes: Supplementary data
Articles
Hongming Miao, Juanjuan Ou, Xuan Zhang, Yujuan Chen, Bingzhong Xue, Hang Shi, Lixia Gan, Liqing Yu, Houjie Liang
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (8): 493–506.
Published: 23 January 2015
... with a FOXO1 inhibitor, an antioxidant that inhibits FOXO1 or IL-1 receptor antagonist alleviates chronic inflammation and insulin resistance in high-fat diet (HFD)-fed mice. Collectively, our data suggest that obesity-associated factors such as NEFA and lipopolysaccharide (LPS) probably adopt this vicious...
Includes: Supplementary data
Articles
Mariëtte R. Boon, Leontine E. H. Bakker, Mariëlle C. Haks, Edwin Quinten, Gert Schaart, Lianne Van Beek, Yanan Wang, Linda Van Schinkel, Vanessa Van Harmelen, A. Edo Meinders, Tom H. M. Ottenhoff, Ko Willems Van Dijk, Bruno Guigas, Ingrid M. Jazet, Patrick C. N. Rensen
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (2): 143–151.
Published: 19 September 2014
... <0.001) levels together with homoeostasis model assessment of insulin resistance (HOMA-IR) (+48%, P <0.001), suggesting development of insulin resistance (IR). Furthermore, the HFHC-diet markedly increased HTG (+118%, P <0.001) and plasma CETP levels (+21%, P <0.001), a marker of liver...
Includes: Supplementary data
Articles
Vanessa Legry, Derrick M. Van Rooyen, Barbara Lambert, Christine Sempoux, Laurence Poekes, Regina Español-Suñer, Olivier Molendi-Coste, Yves Horsmans, Geoffrey C. Farrell, Isabelle A. Leclercq
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (7): 507–518.
Published: 25 June 2014
...)] are hepatic complications of the metabolic syndrome. Endoplasmic reticulum (ER) stress is proposed as a crucial disease mechanism in obese and insulin-resistant animals (such as ob/ob mice) with simple steatosis, but its role in NASH remains controversial. We therefore evaluated the role of ER stress...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (2): 91–100.
Published: 17 March 2014
... resistance in Type 2 diabetic mice resulting from the inhibition of Kupffer cells [ 19 ]. However, the precise effects and molecular mechanisms of GdCl 3 on hepatocytes and the liver are poorly understood. In the present study, we have assessed the effects of GdCl 3 on insulin resistance...
Articles
Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (10): 739–752.
Published: 03 February 2014
... aging is associated with a low-grade inflammation and IR (insulin resistance), we aimed to: (i) analyse the concentration of eHSP72 in elderly people and determine correlation with insulin resistance, and (ii) determine the effects of eHSP72 on β-cell function and viability in human and rodent...
Articles
Valérie Lebrun, Olivier Molendi-Coste, Nicolas Lanthier, Christine Sempoux, Patrice D. Cani, Nico van Rooijen, Peter Stärkel, Yves Horsmans, Isabelle A. Leclercq
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (11): 501–511.
Published: 25 July 2013
... (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression. In NAFLD, steatosis, lipotoxicity and liver inflammation participate to hepatic insulin resistance. The aim of the present study was to verify...
Includes: Supplementary data
Articles
María Cecilia Castro, Flavio Francini, Guillermo Schinella, Claudia Inés Caldiz, María Guillermina Zubiría, Juan José Gagliardino, María Laura Massa
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (12): 681–692.
Published: 10 August 2012
.... Gagliardino (email [email protected] ). 16 12 2011 25 6 2012 28 6 2012 28 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 apocynin fructose hepatic metabolic disorder insulin resistance NADPH oxidase pre-diabetes • The growing...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (9): 545–546.
Published: 13 July 2012
.... These results suggest that TRAIL could be an exciting new therapeutic for treating obesity, but further studies are required to determine its major mechanisms of action. References 1 Hardy O. T. Czech M. P. Corvera S. What causes the insulin resistance underlying obesity? Curr. Opin...
Articles
Stella Bernardi, Giorgio Zauli, Christos Tikellis, Riccardo Candido, Bruno Fabris, Paola Secchiero, Mark E. Cooper, Merlin C. Thomas
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (9): 547–555.
Published: 13 July 2012
... ]. apoptosis high-fat diet inflammation insulin resistance obesity treatment tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) Type 2 diabetes mellitus © The Authors Journal compilation © 2012 Biochemical Society 2012 10 4 2012 14 5 2012 23 5 2012 23 5 2012...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (4): 259–270.
Published: 30 April 2012
...Julio Cesar Fraulob; Vanessa Souza-Mello; Marcia Barbosa Aguila; Carlos Alberto Mandarim-de-Lacerda The aim of the present study was to evaluate the effects of ST (rosuvastatin) and GZ (rosiglitazone) on IR (insulin resistance) and on liver as well as adipose tissue in mice fed on an HF (high-fat...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
... mediate insulin resistance [ 88 , 89 ]. ROS can also be produced during β-oxidation of fatty acids, especially as a by-product of peroxisomal acyl-CoA oxidase activity. Additionally, ROS can be produced by dedicated enzymes, such as NADPH oxidase [ 86 ], present in phagocytic cells, where ROS...
Articles
Satish C. Kalhan, John Edmison, Susan Marczewski, Srinivasan Dasarathy, Lourdes L. Gruca, Carole Bennett, Clarita Duenas, Rocio Lopez
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (4): 179–189.
Published: 04 May 2011
... with estimates of whole body rate of protein turnover and urea synthesis in clinically stable biopsy-confirmed subjects with NASH (non-alcoholic steatohepatitis). Subjects with NASH were more insulin-resistant and had significantly higher plasma concentrations of usCRP (ultrasensitive C-reactive protein), TNFα...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (7): 297–305.
Published: 13 December 2010
... herbal extract insulin resistance metabolic syndrome thiazolidinedione visceral obesity The metabolic syndrome represents a cluster of cardiometabolic risk determinants, including central adiposity, insulin resistance, glucose intolerance, dyslipidaemia and hypertension. The metabolic...
Articles
Bárbara Maiztegui, María I. Borelli, Viviana G. Madrid, Héctor Del Zotto, María A. Raschia, Flavio Francini, María L. Massa, Luis E. Flores, Oscar R. Rebolledo, Juan J. Gagliardino
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (2): 73–80.
Published: 08 October 2010
... (homoeostasis model assessment) for insulin resistance], HOMA-β (HOMA for β-cell function) and liver triacylglycerol content were measured. Pancreas immunomorphometric analyses were also performed. IGT (impaired glucose tolerance), plasma triacylglycerol, fructosamine and insulin levels, HOMA-IR and HOMA-β...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (8): 313–322.
Published: 06 July 2010
... endothelial function flow-mediated vasodilatation heart rate variability insulin resistance Over the past few years, it has been appreciated that blood flow through metabolically active tissues is regulated, and that this may relate to cardiovascular and metabolic health [ 1 , 2 ]. One such tissue...
Articles
Thomas Forst, Matthias M. Weber, Mirjam Löbig, Ute Lehmann, Jürgen Müller, Cloth Hohberg, Christiane Friedrich, Winfried Fuchs, Andreas Pfützner
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (8): 345–351.
Published: 06 July 2010
.... Fasting blood samples were taken at baseline and after 24 weeks of treatment for the measurement of plasma glucose, HbA 1c , insulin, intact proinsulin, adiponectin, Hct (haematocrit) and the assessment of erythrocyte deformability. adiponectin erythrocyte deformability insulin resistance...
Articles
Vanessa Souza-Mello, Bianca M. Gregório, Fernando S. Cardoso-de-Lemos, Laís de Carvalho, Márcia B. Aguila, Carlos A. Mandarim-de-Lacerda
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (6): 239–250.
Published: 08 June 2010
...). Conversely, all drug treatments resulted in significant weight loss, a reversal of insulin resistance, islet and adipocyte hypertrophy, and alleviated hepatic steatosis. Only the HF-T and HF-TS groups had body weights similar to the SC group at the end of the experiment, and the latter treatment reversed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (10): 761–770.
Published: 15 April 2009
...Lisa J. Moran; Samantha K. Hutchison; Caroline Meyer; Sophia Zoungas; Helena J. Teede PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial...
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