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Keywords: insulin secretion
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Articles
Clin Sci (Lond) (2020) 134 (12): 1449–1456.
Published: 18 June 2020
... secretory defect of pancreatic β-cells, owing to disrupted insulin exocytosis, to an extent explains β-cell dysfunction in HCV-infected or CHC milieu. HCV infection negatively regulates first-phase and second-phase insulin secretion by impinging on PKD-dependent insulin secretory granule fission at trans...
Articles
Clin Sci (Lond) (2020) 134 (5): 529–542.
Published: 13 March 2020
...-infected C/O Tg mice, not only in diabetic individuals but also in individuals with impaired fasting glucose levels. Both first-phase and second-phase insulin secretion were impaired, at least partially due to the reduction of exocytosis of secretory insulin-containing granules following HCV infection. Up...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (2): 351–365.
Published: 30 January 2019
... aged. In addition, the absence of SPARC worsens high-fat diet-induced diabetes in mice. Interestingly, although SPARC −/− mice on high-fat diet were sensitive to insulin they showed an impaired insulin secretion capacity. Of note, the expression of glucose transporter 2 in islets of SPARC −/− mice...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (3): 247–260.
Published: 18 January 2017
...Dan Zhang; Wing Yan So; Yi Wang; Shang Ying Wu; Qianni Cheng; Po Sing Leung G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120 plays a direct regulatory role in islet β-cell insulin secretion...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (21): 1901–1911.
Published: 22 September 2016
... insulin secretion by promoting β-cell Ca 2+ influx and cAMP production. After 4-week continuous exposure, a hypoglycaemic property of Netrin-1 was demonstrated, which is probably attributable to improved β-cell function, shown as increased insulin content and preproinsulin mRNA expression. Enhanced islet...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... respectively) stimulates insulin secretion in vitro . There is evidence that the ECS is overactive in Type 2 diabetes, impairing glucose homoeostasis, but little is known about whether it is implicated in islet dysfunction. Therefore the aim of the present study was to investigate the effect of chronic...
Articles
Clin Sci (Lond) (2012) 122 (8): 375–384.
Published: 14 December 2011
...Lin Wu; Anna Olverling; Zhen Huang; Leif Jansson; Hongfen Chao; Xin Gao; Åke Sjöholm GLP-1 (glucagon-like peptide 1) and its mimetic exendin-4 are used against Type 2 diabetes. C-peptide has also proven promising to enhance insulin action. Since insulin secretion in vivo can be rapidly tuned...
Articles
Clin Sci (Lond) (2011) 121 (3): 107–117.
Published: 15 April 2011
..., and BRIN–BD11 cells were used to evaluate cAMP production and insulin secretion. Acute glucose-lowering and insulinotropic actions were evaluated in Swiss TO mice. Subchronic studies on glucose homoeostasis, insulin secretion, food intake and bodyweight were evaluated in ob/ob mice. Liraglutide, N -AcGIP...
Articles
Clin Sci (Lond) (2009) 117 (9): 321–330.
Published: 01 September 2009
... of the glucose- and amino-acid-responsive clonal insulin-secreting cell line BRIN-BD11. Aralar1 overexpression increased long-term (24 h) and acute (20 min) glucose- and amino-acid-stimulated insulin secretion, cellular glucose metabolism, L -alanine and L -glutamine consumption, cellular ATP and glutamate...
Articles
Clin Sci (Lond) (2009) 116 (4): 341–351.
Published: 15 January 2009
... exposure to amino acids. The present study examined the effects of prolonged exposure of β-cells to the metabolizable amino acid L -alanine. Basal insulin release or cellular insulin content were not significantly altered by alanine culture, but acute alanine-induced insulin secretion was suppressed by 74...
Articles
Clin Sci (Lond) (2007) 112 (1): 69–76.
Published: 01 December 2006
... this is achieved remain elusive. To this end, we have studied whether these drugs influence insulin secretion in vivo through effects on islet blood perfusion. Captopril (3 mg/kg of body weight), irbesartan (3 mg/kg of body weight) and pravastatin (0.5 mg/kg of body weight) were injected intravenously...
Articles
Clin Sci (Lond) (2007) 112 (1): 27–42.
Published: 01 December 2006
... , 59 ]. A recent advance in the understanding of the mechanism(s) by which NEFAs modulate insulin secretion in vivo is the discovery of high levels of expression of the membrane-bound G-protein-coupled receptor GPR40, a putative NEFA receptor in human and animal islet β-cell preparations [ 60...
Articles
Clin Sci (Lond) (2005) 109 (5): 447–455.
Published: 24 October 2005
..., secretory function and the integrity of insulin-secreting cells. Specific amino acids may therefore play a key role in β-cell function in vivo . Correspondence: Professor Philip Newsholme (email philip.newsholme@ucd.ie ). 5 5 2005 24 6 2005 27 7 2005 27 7 2005...
Includes: Supplementary data
Articles
Clin Sci (Lond) (1999) 97 (4): 429–436.
Published: 24 August 1999
... Research Society © 1999 1999 C-peptide gastric-inhibiting polypeptide glucagon-like peptide incretin mechanism insulin secretion intestinal hormones postprandial insulinaemia splanchnic blood flow 429Clinical Science (1999) 97, 429 436 (Printed in Great Britain) Splanchnic...
Articles
Clin Sci (Lond) (1993) 85 (3): 327–335.
Published: 01 September 1993
.... The present study was undertaken (a) to measure the antinatriuretic effect of insulin under physiologi- ~~ ~ Key words: antinatriuresis, blood pressure, insulin secretion, potassium. Abbreviations: BP, blood pressure; DBP, diastolic blood pressure; FFA, free fatty acids; HR, heart rate; O G l l , oral glucase...
Articles
Clin Sci (Lond) (1992) 83 (5): 597–605.
Published: 01 November 1992
...Yolanta T. Kruszynska; Janet Munro; Philip D. Home; Neil McIntyre 1. To examine the contributions of hypersecretion and decreased insulin clearance to the hyperinsulinaemia of cirrhosis, insulin secretion was calculated over the day from serum C-peptide concentrations and C-peptide metabolic...
Articles
Clin Sci (Lond) (1991) 81 (5): 685–690.
Published: 01 November 1991
... maintains elevated insulin secretion rates and may, therefore, blunt the ability of insulin to regulate its own secretion in this condition. 13 5 1991 13 6 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 C-peptide insulin secretion type 2 diabetes...
Articles
Clin Sci (Lond) (1991) 81 (1): 101–106.
Published: 01 July 1991
... sulphonylurea derivatives act by increasing B-cell glucose sensitivity. 2. We assessed the effect of gliclazide on glucose-stimulated insulin secretion in eight healthy volunteers. Sixty minute hyperglycaemic glucose clamps (blood glucose levels of 8, 11 and 32 mmol/l) were performed, with and without prior...
Articles
Clin Sci (Lond) (1986) 71 (6): 665–673.
Published: 01 December 1986
... of glucose disposal to insulin; S g , net insulin independent glucose disposal; ϕ 1 , the integral concentration of insulin delivered during the first phase of insulin secretion relative to the initial increase in glucose concentration above a model-derived threshold; ϕ 2 the sensitivity of the rate of rise...
Articles
Clin Sci (Lond) (1985) 68 (5): 567–572.
Published: 01 May 1985
... to increasing concentrations of glucose with a sigmoidal curve for insulin release. 19 11 1984 26 11 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 human islets human pancreatic slices insulin biosynthesis insulin secretion tissue culture Clinical Science...