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Keywords: insulin secretion
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Articles
Clin Sci (Lond) (2020) 134 (12): 1449–1456.
Published: 18 June 2020
... secretory defect of pancreatic β-cells, owing to disrupted insulin exocytosis, to an extent explains β-cell dysfunction in HCV-infected or CHC milieu. HCV infection negatively regulates first-phase and second-phase insulin secretion by impinging on PKD-dependent insulin secretory granule fission at trans...
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Clin Sci (Lond) (2017) 131 (3): 247–260.
Published: 18 January 2017
...Dan Zhang; Wing Yan So; Yi Wang; Shang Ying Wu; Qianni Cheng; Po Sing Leung G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120 plays a direct regulatory role in islet β-cell insulin secretion...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (21): 1901–1911.
Published: 22 September 2016
... insulin secretion by promoting β-cell Ca 2+ influx and cAMP production. After 4-week continuous exposure, a hypoglycaemic property of Netrin-1 was demonstrated, which is probably attributable to improved β-cell function, shown as increased insulin content and preproinsulin mRNA expression. Enhanced islet...
Includes: Supplementary data
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Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... respectively) stimulates insulin secretion in vitro . There is evidence that the ECS is overactive in Type 2 diabetes, impairing glucose homoeostasis, but little is known about whether it is implicated in islet dysfunction. Therefore the aim of the present study was to investigate the effect of chronic...
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Clin Sci (Lond) (2007) 112 (1): 27–42.
Published: 01 December 2006
... characteristic of the fasted state [ 48 ]. In fact, circulating fatty acids are essential for an efficient glucose stimulation of insulin release after prolonged fasting in humans and rats [ 58 , 59 ]. A recent advance in the understanding of the mechanism(s) by which NEFAs modulate insulin secretion...
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Clin Sci (Lond) (1999) 97 (4): 429–436.
Published: 24 August 1999
... in the extrasplanchnic tissues. Thus, in the basal state, the Key words : C-peptide, gastric-inhibiting polypeptide, glucagon-like peptide, incretin mechanism, insulin secretion, intestinal hormones, postprandial insulinaemia, splanchnic blood flow. extrasplanchnic tissues account for 30 40% of whole- body insulin...
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Clin Sci (Lond) (1993) 85 (3): 327–335.
Published: 01 September 1993
.... The present study was undertaken (a) to measure the antinatriuretic effect of insulin under physiologi- ~~ ~ Key words: antinatriuresis, blood pressure, insulin secretion, potassium. Abbreviations: BP, blood pressure; DBP, diastolic blood pressure; FFA, free fatty acids; HR, heart rate; O G l l , oral glucase...
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Clin Sci (Lond) (1991) 81 (5): 685–690.
Published: 01 November 1991
... maintains elevated insulin secretion rates and may, therefore, blunt the ability of insulin to regulate its own secretion in this condition. Clinical Science (1991) 81,685-690 685 Feedback inhibition of insulin secretion in type 2 diabetes C. BAYNES, V. ANYAOKU, D. G. JOHNSTON AND R. S. ELKELES Unit...
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Clin Sci (Lond) (1991) 81 (1): 101–106.
Published: 01 July 1991
... sulphonylurea derivatives act by increasing B-cell glucose sensitivity. 2. We assessed the effect of gliclazide on glucose-stimulated insulin secretion in eight healthy volunteers. Sixty minute hyperglycaemic glucose clamps (blood glucose levels of 8, 11 and 32 mmol/l) were performed, with and without prior...
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Clin Sci (Lond) (1986) 71 (6): 665–673.
Published: 01 December 1986
... of glucose disposal to insulin; S g , net insulin independent glucose disposal; ϕ 1 , the integral concentration of insulin delivered during the first phase of insulin secretion relative to the initial increase in glucose concentration above a model-derived threshold; ϕ 2 the sensitivity of the rate of rise...
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Clin Sci (Lond) (1985) 68 (5): 567–572.
Published: 01 May 1985
... to increasing concentrations of glucose with a sigmoidal curve for insulin release. 19 11 1984 26 11 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 human islets human pancreatic slices insulin biosynthesis insulin secretion tissue culture Clinical Science...