1-20 of 20
Keywords: insulin secretion
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Clin Sci (Lond) (2020) 134 (12): 1449–1456.
Published: 18 June 2020
... secretory defect of pancreatic β-cells, owing to disrupted insulin exocytosis, to an extent explains β-cell dysfunction in HCV-infected or CHC milieu. HCV infection negatively regulates first-phase and second-phase insulin secretion by impinging on PKD-dependent insulin secretory granule fission at trans...
Articles
Articles
Articles
Clin Sci (Lond) (2017) 131 (3): 247–260.
Published: 18 January 2017
...Dan Zhang; Wing Yan So; Yi Wang; Shang Ying Wu; Qianni Cheng; Po Sing Leung G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120 plays a direct regulatory role in islet β-cell insulin secretion...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (21): 1901–1911.
Published: 22 September 2016
... insulin secretion by promoting β-cell Ca 2+ influx and cAMP production. After 4-week continuous exposure, a hypoglycaemic property of Netrin-1 was demonstrated, which is probably attributable to improved β-cell function, shown as increased insulin content and preproinsulin mRNA expression. Enhanced islet...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 124 (7): 467–478.
Published: 07 December 2012
... respectively) stimulates insulin secretion in vitro . There is evidence that the ECS is overactive in Type 2 diabetes, impairing glucose homoeostasis, but little is known about whether it is implicated in islet dysfunction. Therefore the aim of the present study was to investigate the effect of chronic...
Articles
Articles
Articles
Articles
Articles
Articles
Clin Sci (Lond) (2007) 112 (1): 27–42.
Published: 01 December 2006
..., unsaturated fatty acids from glucose-exposed islets represents a novel mechanism for modulating GSIS (glucose-stimulated insulin secretion) from pancreatic β-cells. Hyperlipidaemia is frequently associated with insulin resistance, a condition that is associated with hyperglycaemia and hyperinsulinaemia...
Articles
Articles
Clin Sci (Lond) (1999) 97 (4): 429–436.
Published: 24 August 1999
... Research Society © 1999 1999 C-peptide gastric-inhibiting polypeptide glucagon-like peptide incretin mechanism insulin secretion intestinal hormones postprandial insulinaemia splanchnic blood flow 429Clinical Science (1999) 97, 429 436 (Printed in Great Britain) Splanchnic...
Articles
Clin Sci (Lond) (1993) 85 (3): 327–335.
Published: 01 September 1993
.... The present study was undertaken (a) to measure the antinatriuretic effect of insulin under physiologi- ~~ ~ Key words: antinatriuresis, blood pressure, insulin secretion, potassium. Abbreviations: BP, blood pressure; DBP, diastolic blood pressure; FFA, free fatty acids; HR, heart rate; O G l l , oral glucase...
Articles
Articles
Clin Sci (Lond) (1991) 81 (5): 685–690.
Published: 01 November 1991
... maintains elevated insulin secretion rates and may, therefore, blunt the ability of insulin to regulate its own secretion in this condition. Clinical Science (1991) 81,685-690 685 Feedback inhibition of insulin secretion in type 2 diabetes C. BAYNES, V. ANYAOKU, D. G. JOHNSTON AND R. S. ELKELES Unit...
Articles
Clin Sci (Lond) (1991) 81 (1): 101–106.
Published: 01 July 1991
... sulphonylurea derivatives act by increasing B-cell glucose sensitivity. 2. We assessed the effect of gliclazide on glucose-stimulated insulin secretion in eight healthy volunteers. Sixty minute hyperglycaemic glucose clamps (blood glucose levels of 8, 11 and 32 mmol/l) were performed, with and without prior...
Articles
Clin Sci (Lond) (1986) 71 (6): 665–673.
Published: 01 December 1986
... of glucose disposal to insulin; S g , net insulin independent glucose disposal; ϕ 1 , the integral concentration of insulin delivered during the first phase of insulin secretion relative to the initial increase in glucose concentration above a model-derived threshold; ϕ 2 the sensitivity of the rate of rise...
Articles
Clin Sci (Lond) (1985) 68 (5): 567–572.
Published: 01 May 1985
... to increasing concentrations of glucose with a sigmoidal curve for insulin release. 19 11 1984 26 11 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 human islets human pancreatic slices insulin biosynthesis insulin secretion tissue culture Clinical Science...