... of the most studied matricellular proteins is cellular communication network-2 (CCN2), also called connective tissue growth factor (CTGF), currently considered as a fibrotic marker and a potential therapeutic target. Integrins connect the ECM proteins to the actin cytoskeleton and several downstream signaling...

... by fibroblast activation and fibrosis of the skin and internal organs. Alterations in cell–integrin interaction are sufficient to initiate profibrotic processes. SSc fibroblasts express both αvβ3 and αvβ5 integrins and their activation induces myofibroblasts differentiation. The aim of the present study...

.... Adhesion molecules can be further divided into four subfamilies: the integrins, the selectins, the cadherins and the immunoglobulin superfamily. This article will review our current knowledge of the integrin family of adhesion receptors, focusing principally on their role in the pathogenesis of human...

... stem cells can be isolated both in vitro and direct from the epidermis as they express high levels of functional β 1 integrin family receptors for extracellular matrix proteins. 2. The evidence for integrins as stem cell markers and the insights that have been gained into stem cell behaviour...

...John Savill © 1992 The Biochemical Society and the Medical Research Society 1992 apoptosis integrins thrombospondin Clinical Science (1992) 83, 64%55 (Printed in Great Britain) 649 Glaxo/M RS Young Investigator Prize Macrop hage recognition of senescent neu t rop hi Is John SAVILL...