... interleukin-1 renin-angiotensin system Hypertension (HT) is one of the most important cause of deaths worldwide. Improved treatment strategies for HT, including antihypertensive agents, have increased survival rates. However, hypertensive patients with renal injury are at increased risk for death...

... of the initiating event, the peripheral tissue macrophage can induce an inflammatory response through the release of the prototypical pro-inflammatory cytokines IL-1 (interleukin-1) β and TNF (tumour necrosis factor) α [ 1 ]. These cytokines act on endothelial cells to induce the expression of adhesion molecules...

... gene expression in human osteoblast-like cells. The clinical relevance of our findings requires further investigation. bone metabolism fatty acids interleukin-1 macrophage colony-stimulating factor osteoblasts tumour necrosis factor-. Correspondence: Professor Bruno Baggio (e...

... the effect of endotoxaemia and sepsis on brain interleukin-1 and interleukin-6 expression. 2. Male A/J mice were injected subcutaneously with lipopolysaccharide (10 mg/kg) or an equal volume of saline as control. Sepsis was induced by caecal ligation and puncture (CLP); control mice underwent sham-operation...

... of interleukin 1, tumour necrosis factor and interleukin 6 were investigated in Kupffer cells derived from both young and old animals. 3. Basal production of biological response modifiers was low in cells of both young and old rats. Lipopolysaccharide stimulated production of the same types of monokines...

... and butter for 4 and 8 weeks on subsequent cytokine production by peritoneal macrophages of rats. 4. Tumour necrosis factor production in response to a lipopolysaccharide stimulus and interleukin-1 and interleukin-6 production in response to a tumour necrosis factor challenge were studied. 5. All fats...

... and histologically normal mucosa. 2. Addition of interleukin-1 stimulated release of greater quantities of all these inflammatory mediators, including interleukin-1 itself, from inflamed and normal mucosa. 3. Blockade of cyclo-oxygenase with indomethacin or of lipoxygenase with ICI 207968 or of phospholipase A 2...

...Giulio Pioli; Guiseppina Basini; Mario Pedrazzoni; Giovanni Musetti; Vittorio Ulietti; Donatella Bresciani; Paola Villa; Alberto Bacchi; David Hughe; Graham Russell; Mario Passeri 1. We studied the changes in interleukin-1 and interleukin-6 secretion by peripheral blood mononuclear cells from 12...

...Rhys D. Evans; Vera Ilic; Dermot H. Williamson 1. Administration of tumour necrosis factor (cachectin) and of interleukin-1-α increased the plasma level of non-esterified fatty acids in fed rats, and in the case of interleukin-1-α the blood glycerol level was also increased, suggesting stimulation...

... capacity, per cent saturation of transferrin and serum ferritin level. 4. A significant increase in interleukin-1-type activity was demonstrated immediately and 24 h after exercise ( P <0.01). 5. It is concluded that the metabolic sequelae of sustained exercise are similar, but not analogous...

...-immunization. 3. The effect of rhIL-1β may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development...

... for EVA-bovine serum albumin (0.5–12.5 mg) implants. 5. These observations suggest that continuous endogenous local release of interleukin-1 or interleukin-2 in vivo is sufficient for the development of specific pathological features characterizing chronic immuno-inflammatory diseases. 1 6 1988 6...

...C. I. Westacott; J. T. Whicher; C. W. Hutton; P. A. Dieppe 1. Increased spontaneous production of interleukin-1, measured as lymphocyte-activating factor activity, was seen in unstimulated monocytes from systemic sclerosis patients. 2. Inhibitory activity to interleukin-1 was seen in both normal...

...J. R. Weinberg; D. J. M. Wright; A. Guz 1. The cardiovascular effects of intravenous injections of interleukin-1 (IL-1) and tumour necrosis factor (TNF) have been investigated in the conscious rabbit. They have been compared with the effects of bacterial lipopolysaccharide (LPS) because both IL-1...

...J. C. W. M. Holtslag; H. J. Moshage; J. F. van Pelt; J. A. G. M. Kleuskens; F. W. J. Gribnau; S. H. Yap 1. Monocytic products, especially interleukin-1 (IL-1), play an important role in the acute-phase response. Prostaglandins have been shown to act as second messengers in several physiological...