...Poul F. GEERTSEN; Hans VON DER MAASE; Niels Vidiendal OLSEN; Niels FOGH-ANDERSEN; Steen Levin NIELSEN; Paul P. LEYSSAC 1. Renal haemodynamics, lithium and sodium clearance were measured in 14 patients treated with recombinant interleukin-2 for metastatic renal cell carcinoma. 2. Patients were...

...- and sevenfold increment in T cells and a 17- and eightfold increment in large granular lymphocyte proliferative response. 3. Both cell types internalized more lipoprotein when they were stimulated with interleukin 2. Chylomicrons and low-density lipoprotein internalization was increased threefold and very low...

...D. J. Deehan; S. D. Heys; J. Broom; O. Eremin; P. H. Whiting 1. The T-cell-derived cytokine interleukin-2 may be used to reverse the immune suppression associated with major surgery. However, both major surgical procedures and recombinant interleukin-2 therapy are known to induce renal dysfunction...

... was measured in healthy subjects and in patients with metastatic colorectal cancer before and during infusion of recombinant interleukin-2. Rates of protein synthesis were compared with thymidine uptake in vitro and phenotypic analysis of lymphocytes. 2. The median rate of lymphocyte protein synthesis in four...

...Felix Stockenhuber; Michaela Keil; Christian Wurnig; Robert W. Kurz; Michael Gottsauner-Wolf; Peter Balcke 1. Serum levels of erythropoietin and the immune parameters tumour necrosis factor-α, soluble interleukin-2 receptor, interleukin-2, interleukin-6 and interferon-γ were measured in patients...

... by fatty acids was similar to that previously reported for rat lymphocytes with one exception: oleate did not inhibit human lymphocyte proliferation. 5. The proliferation of T-lymphocytes is dependent upon their ability to synthesize and secrete the cytokine, interleukin-2. In the presence of mitogen...

... interleukin-1α (10 4 –10 5 units) implants induced a qualitatively similar but less intense response. 3. In contrast, recombinant human interleukin-2 (10 2 –10 4 units) implants resulted in early lymphocytic vasculitis (4 days) and the development of a predominantly lymphoid lesion comprised of lymphoblasts...