Search Results | Clinical Science

1-43 of 43

Sort by

Sort Order Select

Articles

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis, Saray Sánchez, Giulio Berti, Belen Pan-Castillo, Anke Nijhuis, Shameer Mehta, Liliane Eleid, Hannah Gordon, Radha Gadhok, Christopher Kimberley, Annamaria Minicozzi, Joanne Chin-Aleong, Roger Feakins, Robert Kypta, James Oliver Lindsay, Andrew Silver

Clin Sci (Lond) (2022) 136 (19): 1405–1423.

DOI: https://doi.org/10.1042/CS20210889

Published: 14 October 2022

...Amy Lewis; Saray Sánchez; Giulio Berti; Belen Pan-Castillo; Anke Nijhuis; Shameer Mehta; Liliane Eleid; Hannah Gordon; Radha Gadhok; Christopher Kimberley; Annamaria Minicozzi; Joanne Chin-Aleong; Roger Feakins; Robert Kypta; James Oliver Lindsay; Andrew Silver Intestinal fibrosis and stricture...

View article titled, Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Includes: Supplementary data

Articles

Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon

Daniel G. Couch, Chris Tasker, Elena Theophilidou, Jonathan N. Lund, Saoirse E. O’Sullivan

Clin Sci (Lond) (2017) 131 (21): 2611–2626.

DOI: https://doi.org/10.1042/CS20171288

Published: 25 October 2017

... colon Cannbinoids Gut inflammation Intestine In health, the gut absorbs nutrients from the lumenal environment into the sterile submucosa without absorbing noxious material, such as bacteria and lipopolysaccharide. The barrier between lumen and submucosa is formed by epithelial cells, which...

View article titled, Cannabidiol and palmitoylethanolamide are anti-inflammatory in the acutely inflamed human colon

Articles

Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice

Qiankun Zhu, Guizhen He, Jie Wang, Yukang Wang, Wei Chen

Clin Sci (Lond) (2017) 131 (11): 1123–1136.

DOI: https://doi.org/10.1042/CS20170074

Published: 17 May 2017

...) injuries. However, the effect of ALDH2 in intestinal I/R is unknown. The present study was set up to determine whether an ALDH2 agonist, Alda-1, could alleviate intestinal injury after gut I/R. In a mouse model of intestinal I/R injury, histological grading, proinflammatory cytokines, oxidative stress...

View article titled, Pretreatment with the ALDH2 agonist Alda-1 reduces intestinal injury induced by ischaemia and reperfusion in mice

Articles

A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Neil A. Mabbott

Clin Sci (Lond) (2015) 129 (7): 529–531.

DOI: https://doi.org/10.1042/CS20150364

Published: 03 July 2015

...Neil A. Mabbott In the intestine, a single layer of epithelial cells sealed together at their apical surfaces by tight junctions helps to prevent the luminal commensal and pathogenic micro-organisms and their toxins from entering host tissues. The intestinal epithelium also helps to maintain...

View article titled, A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

Articles

Age-associated modifications of intestinal permeability and innate immunity in human small intestine

Angela L. Man, Eugenio Bertelli, Silvia Rentini, Mari Regoli, Graham Briars, Mario Marini, Alastair J. M. Watson, Claudio Nicoletti

Clin Sci (Lond) (2015) 129 (7): 515–527.

DOI: https://doi.org/10.1042/CS20150046

Published: 03 July 2015

...Angela L. Man; Eugenio Bertelli; Silvia Rentini; Mari Regoli; Graham Briars; Mario Marini; Alastair J. M. Watson; Claudio Nicoletti The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7–12 years), adult (20–40...

View article titled, Age-associated modifications of intestinal permeability and innate immunity in human small intestine

Includes: Supplementary data

Articles

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease

Stephanie Zwicker, Gisele L. Martinez, Madeleen Bosma, Marco Gerling, Reuben Clark, Mirjam Majster, Jan Söderman, Sven Almer, Elisabeth A. Boström

Clin Sci (Lond) (2015) 129 (3): 281–290.

DOI: https://doi.org/10.1042/CS20150176

Published: 15 May 2015

... conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differentiation factors such as CSF-1 (colony-stimulating factor 1) in homoeostasis and inflammation. IL (interleukin)-34 has recently been discovered as a second ligand for CSF-1R (CSF-1 receptor...

View article titled, Interleukin 34: a new modulator of human and experimental inflammatory bowel disease

Includes: Supplementary data

Articles

Interleukin-34 sustains inflammatory pathways in the gut

Eleonora Franzè, Ivan Monteleone, Maria Laura Cupi, Pamela Mancia, Flavio Caprioli, Irene Marafini, Alfredo Colantoni, Angela Ortenzi, Federica Laudisi, Giuseppe Sica, PierPaolo Sileri, Francesco Pallone, Giovanni Monteleone

Clin Sci (Lond) (2015) 129 (3): 271–280.

DOI: https://doi.org/10.1042/CS20150132

Published: 08 May 2015

... propria mononuclear cells) isolated from normal colon by TNF-α (tumour necrosis factor α) and TLR (Toll-like receptor) ligands and was down-regulated in intestinal biopsies and LPMCs of IBD patients upon treatment with infliximab. Treatment of normal LPMCs with IL-34 increased TNF-α expression in an ERK1...

View article titled, Interleukin-34 sustains inflammatory pathways in the gut

Includes: Supplementary data

Articles

Pyrrolidine dithiocarbamate protects the small bowel from warm ischaemia/reperfusion injury of the intestine: the role of haem oxygenase

Ismail H. Mallick, Marc C. Winslet, Alexander M. Seifalian

Clin Sci (Lond) (2006) 111 (6): 373–380.

DOI: https://doi.org/10.1042/CS20060119

Published: 14 November 2006

...Ismail H. Mallick; Marc C. Winslet; Alexander M. Seifalian IR (ischaemia/reperfusion) injury of the intestine occurs commonly during abdominal surgery. We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion...

View article titled, Pyrrolidine dithiocarbamate protects the small bowel from warm ischaemia/reperfusion injury of the intestine: the role of haem oxygenase

Articles

Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis

Maaike J. BRUINS, Nicolaas E.P. DEUTZ, Peter B. SOETERS

Clin Sci (Lond) (2003) 104 (2): 127–141.

DOI: https://doi.org/10.1042/cs1040127

Published: 10 January 2003

..., The Netherlands (e-mail maaike.bruins@unilever.com ). 3 10 2002 1 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 branched-chain amino acids endotoxaemia enteral nutrition fasting glucose metabolism intestine liver muscle protein metabolism swine...

View article titled, Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis

Articles

Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-κB activity

Dan D. HERSHKO, Bruce W. ROBB, Eric S. HUNGNESS, Guangju LUO, Xialing GUO, Per-Olof HASSELGREN

Clin Sci (Lond) (2002) 103 (4): 381–390.

DOI: https://doi.org/10.1042/cs1030381

Published: 03 September 2002

...Dan D. HERSHKO; Bruce W. ROBB; Eric S. HUNGNESS; Guangju LUO; Xialing GUO; Per-Olof HASSELGREN Previous studies have suggested that the production of interleukin-6 (IL-6) is increased in the intestinal mucosa during inflammation, and that nuclear factor-κB (NF-κB) is an important regulator...

View article titled, Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-κB activity

Articles

Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1)

Kaname SAIDA, Naoko KOMETANI, Tsuyoshi UCHIDE, Youji MITSUI

Clin Sci (Lond) (2002) 103 (s2002): 84S–89S.

DOI: https://doi.org/10.1042/CS103S084S

Published: 01 September 2002

...Kaname SAIDA; Naoko KOMETANI; Tsuyoshi UCHIDE; Youji MITSUI Vasoactive intestinal contractor (VIC)/endothelin-2 (ET2) is a vasoactive peptide hormone comprising 21 amino acids. The complete nucleotide sequence of the full-length gene encoding preproVIC (PPVIC) was determined. The PPVIC gene...

View article titled, Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1)

Articles

Effect of Sepsis on Mucosal Protein Synthesis in Different Parts of the Gastrointestinal Tract in Rats

Takashi Higashiguchi, Yoshifumi Noguchi, William O'Brien, Kenneth Wagner, Josef E. Fischer, Per-Olof Hasselgren

Clin Sci (Lond) (1994) 87 (2): 207–211.

DOI: https://doi.org/10.1042/cs0870207

Published: 01 August 1994

... and puncture, the protein synthesis rates were increased by 40–85% in the mucosa of the small and large intestine and the rectum, whereas in the gastric mucosa, the protein synthesis rate was reduced by approximately 40%. 5. The results suggest that mucosal protein synthesis rates differ in the various regions...

View article titled, Effect of Sepsis on Mucosal Protein Synthesis in Different Parts of the Gastrointestinal Tract in Rats

Articles

Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Sylvia Heeneman, Nicolaas E. P. Deutz

Clin Sci (Lond) (1993) 85 (4): 437–444.

DOI: https://doi.org/10.1042/cs0850437

Published: 01 October 1993

... amino acids and ammonia and production of urea by the liver were determined concomitantly. 2. Methionine sulphoximine treatment for 4 days resulted in a 50% decrease in arterial glutamine concentration. Although the glutamine consumption and the intracellular glutamine concentration of the intestine...

View article titled, Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats

Articles

Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

N. E. P. Deutz, P. L. M. Reijven, G. Athanasas, P. B. Soeters

Clin Sci (Lond) (1992) 83 (5): 607–614.

DOI: https://doi.org/10.1042/cs0830607

Published: 01 November 1992

... metabolism possibly represents an indication of increased substrate utilization by the immune system. © 1992 The Biochemical Society and the Medical Research Society 1992 Clinical Science (1992) 83, 607-614 (Printed in Great Britain) Post-operative changes in hepatic, intestinal, splenic and muscle...

View article titled, Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

Articles

Transport and metabolism of 6-thioguanine and 6-mercaptopurine in mouse small intestine

J. R. Bronk, Norma Lister, M. I. Shaw

Clin Sci (Lond) (1988) 74 (6): 629–638.

DOI: https://doi.org/10.1042/cs0740629

Published: 01 June 1988

...J. R. Bronk; Norma Lister; M. I. Shaw 1. The transport of 6-thioguanine and 6-mercaptopurine has been studied with isolated jejunal loops of mouse small intestine. H.p.l.c. was used to identify and quantify the thiopurines and their metabolites in the serosal secretions. 2. When the lumen...

View article titled, Transport and metabolism of 6-thioguanine and 6-mercaptopurine in mouse small intestine

Articles

Epithelial cell proliferation and intestinal absorptive function during starvation and refeeding in the rat

R. A. Goodlad, J. A. Plumb, N. A. Wright

Clin Sci (Lond) (1988) 74 (3): 301–306.

DOI: https://doi.org/10.1042/cs0740301

Published: 01 March 1988

...R. A. Goodlad; J. A. Plumb; N. A. Wright 1. Intestinal epithelial cell production and intestinal absorption were measured in fed, starved and refed rats. 2. Four days' starvation significantly decreased the crypt cell production rate (CCPR), absorption, small intestinal length and crypt cell...

View article titled, Epithelial cell proliferation and intestinal absorptive function during starvation and refeeding in the rat

Articles

A comparison of the structural integrity of several commonly used preparations of rat small intestine in vitro

Jane A. Plumb, David Burston, Terry G. Baker, Michael L. G. Gardner

Clin Sci (Lond) (1987) 73 (1): 53–59.

DOI: https://doi.org/10.1042/cs0730053

Published: 01 July 1987

...Jane A. Plumb; David Burston; Terry G. Baker; Michael L. G. Gardner 1. The structural integrities of various preparations of rat small intestine for the study of absorption in vitro have been compared after incubation or perfusion. 2. Perfused intestines removed from anaesthetized rats, and thus...

View article titled, A comparison of the structural integrity of several commonly used preparations of rat small intestine in vitro

Articles

Effects of sodium replacement on uptake of the dipeptide glycylsarcosine by hamster jejunum in vitro

D. Burston, D. M. Matthews

Clin Sci (Lond) (1987) 73 (1): 61–68.

DOI: https://doi.org/10.1042/cs0730061

Published: 01 July 1987

... doubtful whether transport of this peptide into the intestinal cells is by co-transport with Na + , and the whole matter of Na + -dependence of intestinal peptide transport is in question. 12 1 1987 26 1 1987 © 1970 The Biochemical Society and the Medical Research Society 1970...

View article titled, Effects of sodium replacement on uptake of the dipeptide glycylsarcosine by hamster jejunum in vitro

Articles

Absorption of 5-fluorouracil and related pyrimidines in rat small intestine

J. R. Bronk, Norma Lister, Susan Lynch

Clin Sci (Lond) (1987) 72 (6): 705–716.

DOI: https://doi.org/10.1042/cs0720705

Published: 01 June 1987

...J. R. Bronk; Norma Lister; Susan Lynch 1. The transport of 5-fluorouracil, uracil and thymine has been studied with isolated jejunal loops of rat small intestine. High performance liquid chromatography was used to identify the pyrimidines and measure their concentrations. 2. When the lumen...

View article titled, Absorption of 5-fluorouracil and related pyrimidines in rat small intestine

Articles

The relationship between intestinal crypt cell production and intestinal water absorption measured in vitro in the rat

R. A. Goodlad, J. A. Plumb, N. A. Wright

Clin Sci (Lond) (1987) 72 (3): 297–304.

DOI: https://doi.org/10.1042/cs0720297

Published: 01 March 1987

...R. A. Goodlad; J. A. Plumb; N. A. Wright 1. In studies on intestinal adaptation it is often important to obtain contemporaneous data on the rate of cell production and the functional status of the intestine. 2. The measure of the rate of accumulation of vincristine arrested metaphases...

View article titled, The relationship between intestinal crypt cell production and intestinal water absorption measured in vitro in the rat

Articles

Alterations of intestinal membrane-bound enzymes in three types of hypertensive rats

M. Gilles-Baillien, P. G. Carlier, G. L. Rorive

Clin Sci (Lond) (1986) 70 (6): 617–626.

DOI: https://doi.org/10.1042/cs0700617

Published: 01 June 1986

... found. These differences occur in the young prehypertensive SHR as well as in the adult animal. 3. In the DOCA-treated rat, the only significant alteration in crude membrane fractions is a decreased Mg 2+ -ATPase activity at all regions of intestinal mucosa. In purified jejunal brush-border membranes...

View article titled, Alterations of intestinal membrane-bound enzymes in three types of hypertensive rats

Articles

Uptake of a Series of Neutral Dipeptides Including l-Alanyl-l-Alanine, Glycylglycine and Glycylsarcosine by Hamster Jejunum in Vitro

D. M. Matthews, D. Burston

Clin Sci (Lond) (1984) 67 (5): 541–549.

DOI: https://doi.org/10.1042/cs0670541

Published: 01 November 1984

... completely inhibit uptake of L-valyl-L-valine. There may be more than one uptake system for intact peptides, but we cannot yet suggest an explanation for all the results on inhibitions of uptake. Key words: absorption kinetics, competition for absorption, intestine, peptide absorption. Introduction We have...

View article titled, Uptake of a Series of Neutral Dipeptides Including l-Alanyl-l-Alanine, Glycylglycine and Glycylsarcosine by Hamster Jejunum in Vitro

Articles

Uptake of l-valyl-l-Valine and Glycylsarcosine by Hamster Jejunum in Vitro

D. Burston, R. A. Wapnir, E. Taylor, D. M. Matthews

Clin Sci (Lond) (1982) 62 (6): 617–626.

DOI: https://doi.org/10.1042/cs0620617

Published: 01 June 1982

... than the more lipophilic l-leucyl-l-leucine, but do suggest how such a situation could arise. absorption kinetics competition for absorption intestine peptide absorption © 1982 The Biochemical Society and the Medical Research Society 1982 9 11 1981 12 1 1982 Clinical...

View article titled, Uptake of l-valyl-l-Valine and Glycylsarcosine by Hamster Jejunum in Vitro

Articles

Diurnal Variation in the Intestinal Toxicity of 5-Fluorouracil in the Rat

M. L. G. Gardner, Jane A. Plumb

Clin Sci (Lond) (1981) 61 (6): 717–722.

DOI: https://doi.org/10.1042/cs0610717

Published: 01 December 1981

...M. L. G. Gardner; Jane A. Plumb 1. Water absorption rates by small intestine in vitro and the incidence of diarrhoea in vivo were estimated after 5-fluorouracil was injected into rats at various times of day and night. 2. Impairment of water absorption and the incidence of diarrhoea were minimal...

View article titled, Diurnal Variation in the Intestinal Toxicity of 5-Fluorouracil in the Rat

Articles

The Influence of Carbohydrate Gelling Agents on Rat Intestinal Transport of Monosaccharides and Neutral Amino Acids in Vitro

B. Elsenhans, U. Süfke, R. Blume, W. F. Caspary

Clin Sci (Lond) (1980) 59 (5): 373–380.

DOI: https://doi.org/10.1042/cs0590373

Published: 01 November 1980

...B. Elsenhans; U. Süfke; R. Blume; W. F. Caspary 1. In the present investigation with rings of everted rat small intestine, carbohydrate gelling agents (plant polysaccharides) such as guaran, pectin, tragacanth, carubin and carrageenan were employed to study their direct effect on intestinal...

View article titled, The Influence of Carbohydrate Gelling Agents on Rat Intestinal Transport of Monosaccharides and Neutral Amino Acids in Vitro

Articles

Influx of Glycylsarcosine and l-Lysyl-l-Lysine into Hamster Jejunum in Vitro

E. Taylor, D. Burston, D. M. Matthews

Clin Sci (Lond) (1980) 58 (3): 221–225.

DOI: https://doi.org/10.1042/cs0580221

Published: 01 March 1980

...). 13 7 1979 8 11 1979 © 1980 The Biochemical Society and the Medical Research Society 1980 absorption kinetics competition for absorption intestine peptide absorption Clinical Science (1980) 58.221-225 Influx of glycylsarcosine and L-lysyl-L-lysine into hamster jejunum in vitro...

View article titled, Influx of Glycylsarcosine and l-Lysyl-l-Lysine into Hamster Jejunum in Vitro

Articles

Interaction of Amino Acids with Glycyl-l-leucine Hydrolysis and Transport in Monkey Small Intestine

V. Ganapathy, A. N. Radhakrishnan

Clin Sci (Lond) (1979) 57 (6): 521–527.

DOI: https://doi.org/10.1042/cs0570521

Published: 01 December 1979

...V. Ganapathy; A. N. Radhakrishnan 1. There are two saturable transport processes in the monkey small intestine for glycyl-l-leucine, one with K max 1 μmol min −1 g −1 wet weight of tissue and an affinity constant ( k t ) of 5 mmol/l, and the other with V max. 3·9 μmol min −1 g −1 wet weight...

View article titled, Interaction of Amino Acids with Glycyl-l-leucine Hydrolysis and Transport in Monkey Small Intestine

Articles

Release of Dipeptide Hydrolase Activities from Rat Small Intestine Perfused in Vitro and in Vivo

M. L. G. Gardner, Jane A. Plumb

Clin Sci (Lond) (1979) 57 (6): 529–534.

DOI: https://doi.org/10.1042/cs0570529

Published: 01 December 1979

...M. L. G. Gardner; Jane A. Plumb 1. Hydrolase activities against three dipeptides were measured in mucosal cytoplasm in unperfused intestines and in mucosal cytoplasm, luminal effluents and serosal secretions after perfusion in vitro and in vivo for 1 h. Intestines in vitro were prepared both from...

View article titled, Release of Dipeptide Hydrolase Activities from Rat Small Intestine Perfused in Vitro and in Vivo

Articles

Effects of ‘Elemental’ Diets on Absorptive and Enzymic Activities and on 5-Fluorouracil Toxicity in Rat Small Intestine

M. L. G. Gardner, R. C. Heading

Clin Sci (Lond) (1979) 56 (3): 243–249.

DOI: https://doi.org/10.1042/cs0560243

Published: 01 March 1979

...M. L. G. Gardner; R. C. Heading 1. Water absorption and cytoplasmic dipeptidase activities were determined in isolated rat small intestine after animals had fed on various ‘elemental’ diets or a standard rat diet and after a single injection of 5-fluorouracil. 2. Vivonex diets were associated...

View article titled, Effects of ‘Elemental’ Diets on Absorptive and Enzymic Activities and on 5-Fluorouracil Toxicity in Rat Small Intestine

Articles

Kinetics of Mucosal Influx of Glycylsarcosine, Glycine and Leucine into Hamster Jejunum and Ileum in Vitro

H. P. Schedl, D. Burston, E. Taylor, D. M. Matthews

Clin Sci (Lond) (1979) 56 (1): 25–31.

DOI: https://doi.org/10.1042/cs0560025

Published: 01 January 1979

...H. P. Schedl; D. Burston; E. Taylor; D. M. Matthews 1. This paper describes an investigation of the kinetics of influx of the dipeptide glycylsarcosine and the amino acids glycine and l-leucine into rings of everted hamster small intestine in vitro , in proximal and distal small intestine (jejunum...

View article titled, Kinetics of Mucosal Influx of Glycylsarcosine, Glycine and Leucine into Hamster Jejunum and Ileum in Vitro

Articles

Influx of Two Dipeptides, Glycylsarcosine and l-glutamyl-l-glutamic Acid, into hamster Jejunum in Vitro

D. M. Matthews, R. H. Gandy, E. Taylor, D. Burston

Clin Sci (Lond) (1979) 56 (1): 15–23.

DOI: https://doi.org/10.1042/cs0560015

Published: 01 January 1979

... of one of the peptides by a system unavailable to the other. 13 3 1978 24 7 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 absorption kinetics competition for absorption intestine peptide absorption simple diffusion Clinical Science (1979) 56,15-23...

View article titled, Influx of Two Dipeptides, Glycylsarcosine and l-glutamyl-l-glutamic Acid, into hamster Jejunum in Vitro

Articles

The Effects of Prednisolone on the Rat Enterocyte at a Subcellular Level

R. M. Batt, G. Wells, T. J. Peters

Clin Sci Mol Med (1978) 55 (5): 435–443.

DOI: https://doi.org/10.1042/cs0550435

Published: 01 November 1978

... The Biochemical Society and the Medical Research Society 1978 brush border enterocyte ileum intestine jejunum steroid subcellular fractionation Clinical Science and Molecular Medicine (1 978) 55,435-443 The effects of prednisolone on the rat enterocyte at a subcellular level R . M. B A T T , G. W E...

View article titled, The Effects of Prednisolone on the Rat Enterocyte at a Subcellular Level

Articles

Analytical Subcellular Fractionation Studies on Enterocytes from the Jejunum and Ileum of the Rat and Some Properties of Brush-Border Alkaline Phosphatase

R. M. Batt, T. J. Peters

Clin Sci Mol Med (1978) 55 (2): 157–165.

DOI: https://doi.org/10.1042/cs0550157

Published: 01 August 1978

... fragility. 12 10 1977 13 3 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 alkaline phosphatase brush border enterocyte ileum intestine jejunum subcellular fractionation Clinical Science and Molecular Medicine (1978) 55,157-165 Analytical subcellular...

View article titled, Analytical Subcellular Fractionation Studies on Enterocytes from the Jejunum and Ileum of the Rat and Some Properties of Brush-Border Alkaline Phosphatase

Articles

Intestinal Transport of Salt and Water

L. A. Turnberg

Clin Sci Mol Med (1978) 54 (4): 337–348.

DOI: https://doi.org/10.1042/cs0540337

Published: 01 April 1978

...L. A. Turnberg © 1978 The Biochemical Society and the Medical Research Society 1978 intestine intestine sodium transport Clinical Science and Molecular Medicine (1978) 54,337-348 EDITORIAL REVIEW Intestinal transport of salt and water L. A. TURNBERG Department of Medicine, Hope...

View article titled, Intestinal Transport of Salt and Water

Articles

Changes in Absorptive and Peptide Hydrolase Activities in Rat Small Intestine after Administration of 5-Fluorouracil

M. L. G. Gardner, R. R. Samson, R. C. Heading

Clin Sci Mol Med (1978) 54 (4): 411–418.

DOI: https://doi.org/10.1042/cs0540411

Published: 01 April 1978

...M. L. G. Gardner; R. R. Samson; R. C. Heading 1. Glucose absorption, water absorption and dipeptide hydrolase activities have been determined in isolated rat small intestine at 1, 3, 5 and 21 days after a single intraperitoneal injection of 5-fluorouracil. 2. Absorption rates and enzyme activities...

View article titled, Changes in Absorptive and Peptide Hydrolase Activities in Rat Small Intestine after Administration of 5-Fluorouracil

Articles

Coeliac Disease: The Abolition of Gliadin Toxicity by Enzymes from Aspergillus Niger

J. J. Phelan, Fiona M. Stevens, B. McNicholl, P. F. Fottrell, C. F. McCarthy

Clin Sci Mol Med (1977) 53 (1): 35–43.

DOI: https://doi.org/10.1042/cs0530035

Published: 01 July 1977

... used to assess the toxicity of the carbohydrase-treated gliadin. 3. Gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. 4. The primary structure of the gliadin proteins was not altered by the enzyme treatment. 2 11 1976 2 2 1977 © 1977...

View article titled, Coeliac Disease: The Abolition of Gliadin Toxicity by Enzymes from Aspergillus Niger

Articles

Intestinal Absorption of Glycine and Glycyl-L-Proline in the Rat

R. C. Heading, H. P. Schedl, L. D. Stegink, D. L. Miller

Clin Sci Mol Med (1977) 52 (6): 607–614.

DOI: https://doi.org/10.1042/cs0520607

Published: 01 June 1977

... as free amino acid. This reflux of glycine and proline was not proportional to their concentrations in the mucosa. 2 8 1976 14 2 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 absorption glycine glycyl-l-proline intestine peptide Clinical Science...

View article titled, Intestinal Absorption of Glycine and Glycyl-L-Proline in the Rat

Articles

The Mechanism for Small-Bowel Adaptation in Lactating Rats

Elwyn Elias, R. H. Dowling

Clin Sci Mol Med (1976) 51 (5): 427–433.

DOI: https://doi.org/10.1042/cs0510427

Published: 01 November 1976

...Elwyn Elias; R. H. Dowling 1. To study the relative contributions of luminal nutrition, bile and pancreatic secretions and hormonal factors in intestinal adaptation, lactation hyperphagia was chosen as a model for increased luminal nutrition, either alone (intestinal transection control group...

View article titled, The Mechanism for Small-Bowel Adaptation in Lactating Rats

Articles

Absorption of Galactose by the Rat Small Intestine in Vivo : Proximal—Distal Kinetic Gradients and a New Method to Express Absorption Per Enterocyte

R. M. Batt, T. J. Peters

Clin Sci Mol Med (1976) 50 (6): 499–509.

DOI: https://doi.org/10.1042/cs0500499

Published: 01 June 1976

...R. M. Batt; T. J. Peters 1. The absorption in vivo of d-galactose by the rat small intestine has been examined in proximal jejunum and distal ileum by use of a recirculation—perfusion technique. 2. Multiple sequential perfusions over 4 h produced no subsequent functional or morphological damage...

View article titled, Absorption of Galactose by the Rat Small Intestine in Vivo : Proximal—Distal Kinetic Gradients and a New Method to Express Absorption Per Enterocyte

Articles

Effects of Prednisolone on the Small Intestinal Mucosa of the Rat

R. M. Batt, T. J. Peters

Clin Sci Mol Med (1976) 50 (6): 511–523.

DOI: https://doi.org/10.1042/cs0500511

Published: 01 June 1976

... absorption corticosteroids enterocyte enzymology galactose ileum intestine jejunum kinetics morphology phlorrhizin prednisolone Clinical Science and Molecular Medicine (1976) 50, 51 1-523. Effects of prednisolone on the small intestinal mucosa of the rat R. M. BATT AND T. J. PETERS Royal...

View article titled, Effects of Prednisolone on the Small Intestinal Mucosa of the Rat

Articles

Analytical Subcellular Fractionation Studies on Rat Liver and on Isolated Jejunal Enterocytes with Special Reference to the Separation of Lysosomes, Peroxisomes and Mitochondria

T. J. Peters, H. Shio

Clin Sci Mol Med (1976) 50 (5): 355–366.

DOI: https://doi.org/10.1042/cs0500355

Published: 01 May 1976

... and enterocytes were compared. Key words: brush borders, cytosol, enterocytes, intestine, liver, lysosomes, microsomes, mito- chondria, peroxisomes, subcellular fractionation. Introduction There have been several previous attempts to perform subcellular fractionation of cells of the small intestine but most...

View article titled, Analytical Subcellular Fractionation Studies on Rat Liver and on Isolated Jejunal Enterocytes with Special Reference to the Separation of Lysosomes, Peroxisomes and Mitochondria

Articles

The Interrelations of Faecal Ammonia, pH and Bicarbonate: Evidence of Colonic Absorption of Ammonia by Non-Ionic Diffusion

P. F. Down, L. Agostini, J. Murison, O. M. Wrong

Clin Sci (1972) 43 (1): 101–114.

DOI: https://doi.org/10.1042/cs0430101

Published: 01 July 1972

... reaction that continues to generate unionized ammonia. 18 2 1972 © 1972 The Biochemical Society and the Medical Research Society 1972 faeces colon intestine pH ammonia bicarbonate absorption Clinical Science (1972) 43, 101-114. THE INTERRELATIONS O F FAECAL AMMONIA, pH...

View article titled, The Interrelations of Faecal Ammonia, pH and Bicarbonate: Evidence of Colonic Absorption of Ammonia by Non-Ionic Diffusion

Articles

Intestinal Ammonia in Uraemia: The Effect of a Urease Inhibitor, Acetohydroxamic Acid

J. D. Swales, J. D. Tange, D. J. Evans

Clin Sci (1972) 42 (1): 105–112.

DOI: https://doi.org/10.1042/cs0420105

Published: 01 January 1972

...J. D. Swales; J. D. Tange; D. J. Evans 1. The effects of intestinal ammonia in uraemia have been studied by administering a urease inhibitor, acetohydroxamic acid, to bilaterally nephrectomized rats. 2. Ammonia concentration was significantly decreased in the colon although it remained slightly...

View article titled, Intestinal Ammonia in Uraemia: The Effect of a Urease Inhibitor, Acetohydroxamic Acid

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only