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Keyword: intestine
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Articles
Clin Sci (Lond) (2017) 131 (21): 2611-2626.
Published: 25 October 2017
... colon Cannbinoids Gut inflammation Intestine In health, the gut absorbs nutrients from the lumenal environment into the sterile submucosa without absorbing noxious material, such as bacteria and lipopolysaccharide. The barrier between lumen and submucosa is formed by epithelial cells, which...
Articles
Clin Sci (Lond) (2017) 131 (11): 1123-1136.
Published: 17 May 2017
...) injuries. However, the effect of ALDH2 in intestinal I/R is unknown. The present study was set up to determine whether an ALDH2 agonist, Alda-1, could alleviate intestinal injury after gut I/R. In a mouse model of intestinal I/R injury, histological grading, proinflammatory cytokines, oxidative stress...
Articles
Clin Sci (Lond) (2015) 129 (7): 529-531.
Published: 03 July 2015
...Neil A. Mabbott In the intestine, a single layer of epithelial cells sealed together at their apical surfaces by tight junctions helps to prevent the luminal commensal and pathogenic micro-organisms and their toxins from entering host tissues. The intestinal epithelium also helps to maintain...
Articles
Clin Sci (Lond) (2015) 129 (7): 515-527.
Published: 03 July 2015
...Angela L. Man; Eugenio Bertelli; Silvia Rentini; Mari Regoli; Graham Briars; Mario Marini; Alastair J. M. Watson; Claudio Nicoletti The physical and immunological properties of the human intestinal epithelial barrier in aging are largely unknown. Ileal biopsies from young (7–12 years), adult (20–40...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (3): 281-290.
Published: 15 May 2015
... conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differentiation factors such as CSF-1 (colony-stimulating factor 1) in homoeostasis and inflammation. IL (interleukin)-34 has recently been discovered as a second ligand for CSF-1R (CSF-1 receptor...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (3): 271-280.
Published: 08 May 2015
...-regulated in LPMCs (lamina propria mononuclear cells) isolated from normal colon by TNF-α (tumour necrosis factor α) and TLR (Toll-like receptor) ligands and was down-regulated in intestinal biopsies and LPMCs of IBD patients upon treatment with infliximab. Treatment of normal LPMCs with IL-34 increased TNF...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2006) 111 (6): 373-380.
Published: 14 November 2006
...Ismail H. Mallick; Marc C. Winslet; Alexander M. Seifalian IR (ischaemia/reperfusion) injury of the intestine occurs commonly during abdominal surgery. We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion. In...
Articles
Clin Sci (Lond) (2003) 104 (2): 127-141.
Published: 10 January 2003
... Netherlands (e-mail maaike.bruins@unilever.com ). 3 10 2002 1 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 branched-chain amino acids endotoxaemia enteral nutrition fasting glucose metabolism intestine liver muscle protein metabolism swine...
Articles
Clin Sci (Lond) (2002) 103 (4): 381-390.
Published: 03 September 2002
...Dan D. HERSHKO; Bruce W. ROBB; Eric S. HUNGNESS; Guangju LUO; Xialing GUO; Per-Olof HASSELGREN Previous studies have suggested that the production of interleukin-6 (IL-6) is increased in the intestinal mucosa during inflammation, and that nuclear factor-κB (NF-κB) is an important regulator of the...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 84S-89S.
Published: 01 September 2002
...Kaname SAIDA; Naoko KOMETANI; Tsuyoshi UCHIDE; Youji MITSUI Vasoactive intestinal contractor (VIC)/endothelin-2 (ET2) is a vasoactive peptide hormone comprising 21 amino acids. The complete nucleotide sequence of the full-length gene encoding preproVIC (PPVIC) was determined. The PPVIC gene...
Articles
Clin Sci (Lond) (1994) 87 (2): 207-211.
Published: 01 August 1994
... puncture, the protein synthesis rates were increased by 40–85% in the mucosa of the small and large intestine and the rectum, whereas in the gastric mucosa, the protein synthesis rate was reduced by approximately 40%. 5. The results suggest that mucosal protein synthesis rates differ in the various regions...
Articles
Clin Sci (Lond) (1993) 85 (4): 437-444.
Published: 01 October 1993
... amino acids and ammonia and production of urea by the liver were determined concomitantly. 2. Methionine sulphoximine treatment for 4 days resulted in a 50% decrease in arterial glutamine concentration. Although the glutamine consumption and the intracellular glutamine concentration of the intestine...
Articles
Clin Sci (Lond) (1992) 83 (5): 607-614.
Published: 01 November 1992
... splenic metabolism possibly represents an indication of increased substrate utilization by the immune system. 5 6 1992 29 6 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 amino acids ammonia blood flow glucose glutamine intestine lactate liver...
Articles
Clin Sci (Lond) (1988) 74 (6): 629-638.
Published: 01 June 1988
...J. R. Bronk; Norma Lister; M. I. Shaw 1. The transport of 6-thioguanine and 6-mercaptopurine has been studied with isolated jejunal loops of mouse small intestine. H.p.l.c. was used to identify and quantify the thiopurines and their metabolites in the serosal secretions. 2. When the lumen of the...
Articles
Clin Sci (Lond) (1988) 74 (3): 301-306.
Published: 01 March 1988
...R. A. Goodlad; J. A. Plumb; N. A. Wright 1. Intestinal epithelial cell production and intestinal absorption were measured in fed, starved and refed rats. 2. Four days' starvation significantly decreased the crypt cell production rate (CCPR), absorption, small intestinal length and crypt cell...
Articles
Clin Sci (Lond) (1987) 73 (1): 53-59.
Published: 01 July 1987
...Jane A. Plumb; David Burston; Terry G. Baker; Michael L. G. Gardner 1. The structural integrities of various preparations of rat small intestine for the study of absorption in vitro have been compared after incubation or perfusion. 2. Perfused intestines removed from anaesthetized rats, and thus...
Articles
Clin Sci (Lond) (1987) 73 (1): 61-68.
Published: 01 July 1987
... doubtful whether transport of this peptide into the intestinal cells is by co-transport with Na + , and the whole matter of Na + -dependence of intestinal peptide transport is in question. 12 1 1987 26 1 1987 © 1970 The Biochemical Society and the Medical Research Society 1970...
Articles
Clin Sci (Lond) (1987) 72 (6): 705-716.
Published: 01 June 1987
...J. R. Bronk; Norma Lister; Susan Lynch 1. The transport of 5-fluorouracil, uracil and thymine has been studied with isolated jejunal loops of rat small intestine. High performance liquid chromatography was used to identify the pyrimidines and measure their concentrations. 2. When the lumen of the...
Articles
Clin Sci (Lond) (1987) 72 (3): 297-304.
Published: 01 March 1987
...R. A. Goodlad; J. A. Plumb; N. A. Wright 1. In studies on intestinal adaptation it is often important to obtain contemporaneous data on the rate of cell production and the functional status of the intestine. 2. The measure of the rate of accumulation of vincristine arrested metaphases in...
Articles
Clin Sci (Lond) (1986) 70 (6): 617-626.
Published: 01 June 1986
... found. These differences occur in the young prehypertensive SHR as well as in the adult animal. 3. In the DOCA-treated rat, the only significant alteration in crude membrane fractions is a decreased Mg 2+ -ATPase activity at all regions of intestinal mucosa. In purified jejunal brush-border membranes...
Articles
Clin Sci (Lond) (1984) 67 (5): 541-549.
Published: 01 November 1984
... and the Medical Research Society 1984 absorption kinetics competition for absorption intestine peptide absorption Clinical Science (1984) 67, 541-549 541 I Jptake of a series of neutral dipeptides including L-alanyl-L- alanine, glycylglycine and glycylsarcosine by hamster jejunum in vitro...
Articles
Clin Sci (Lond) (1982) 62 (6): 617-626.
Published: 01 June 1982
... than the more lipophilic l-leucyl-l-leucine, but do suggest how such a situation could arise. 9 11 1981 12 1 1982 © 1982 The Biochemical Society and the Medical Research Society 1982 absorption kinetics competition for absorption intestine peptide absorption Clinical...
Articles
Clin Sci (Lond) (1981) 61 (6): 717-722.
Published: 01 December 1981
...M. L. G. Gardner; Jane A. Plumb 1. Water absorption rates by small intestine in vitro and the incidence of diarrhoea in vivo were estimated after 5-fluorouracil was injected into rats at various times of day and night. 2. Impairment of water absorption and the incidence of diarrhoea were minimal in...
Articles
Clin Sci (Lond) (1980) 59 (5): 373-380.
Published: 01 November 1980
...B. Elsenhans; U. Süfke; R. Blume; W. F. Caspary 1. In the present investigation with rings of everted rat small intestine, carbohydrate gelling agents (plant polysaccharides) such as guaran, pectin, tragacanth, carubin and carrageenan were employed to study their direct effect on intestinal...
Articles
Clin Sci (Lond) (1980) 58 (3): 221-225.
Published: 01 March 1980
...). 13 7 1979 8 11 1979 © 1980 The Biochemical Society and the Medical Research Society 1980 absorption kinetics competition for absorption intestine peptide absorption Clinical Science (1980) 58.221-225 Influx of glycylsarcosine and L-lysyl-L-lysine into hamster jejunum in vitro...
Articles
Clin Sci (Lond) (1979) 57 (6): 521-527.
Published: 01 December 1979
...V. Ganapathy; A. N. Radhakrishnan 1. There are two saturable transport processes in the monkey small intestine for glycyl-l-leucine, one with K max 1 μmol min −1 g −1 wet weight of tissue and an affinity constant ( k t ) of 5 mmol/l, and the other with V max. 3·9 μmol min −1 g −1 wet weight of...
Articles
Clin Sci (Lond) (1979) 57 (6): 529-534.
Published: 01 December 1979
...M. L. G. Gardner; Jane A. Plumb 1. Hydrolase activities against three dipeptides were measured in mucosal cytoplasm in unperfused intestines and in mucosal cytoplasm, luminal effluents and serosal secretions after perfusion in vitro and in vivo for 1 h. Intestines in vitro were prepared both from...
Articles
Clin Sci (Lond) (1979) 56 (3): 243-249.
Published: 01 March 1979
...M. L. G. Gardner; R. C. Heading 1. Water absorption and cytoplasmic dipeptidase activities were determined in isolated rat small intestine after animals had fed on various ‘elemental’ diets or a standard rat diet and after a single injection of 5-fluorouracil. 2. Vivonex diets were associated with...
Articles
Clin Sci (Lond) (1979) 56 (1): 25-31.
Published: 01 January 1979
...H. P. Schedl; D. Burston; E. Taylor; D. M. Matthews 1. This paper describes an investigation of the kinetics of influx of the dipeptide glycylsarcosine and the amino acids glycine and l-leucine into rings of everted hamster small intestine in vitro , in proximal and distal small intestine (jejunum...
Articles
Clin Sci (Lond) (1979) 56 (1): 15-23.
Published: 01 January 1979
... mmol/l) there is appreciable uptake of one of the peptides by a system unavailable to the other. 13 3 1978 24 7 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 absorption kinetics competition for absorption intestine peptide absorption simple...
Articles
Clin Sci Mol Med (1978) 55 (5): 435-443.
Published: 01 November 1978
... Biochemical Society and the Medical Research Society 1978 brush border enterocyte ileum intestine jejunum steroid subcellular fractionation Clinical Science and Molecular Medicine (1 978) 55,435-443 The effects of prednisolone on the rat enterocyte at a subcellular level R . M. B A T T , G. W E...
Articles
Clin Sci Mol Med (1978) 55 (2): 157-165.
Published: 01 August 1978
... fragility. 12 10 1977 13 3 1978 © 1978 The Biochemical Society and the Medical Research Society 1978 alkaline phosphatase brush border enterocyte ileum intestine jejunum subcellular fractionation Clinical Science and Molecular Medicine (1978) 55,157-165 Analytical subcellular...
Articles
Clin Sci Mol Med (1978) 54 (4): 337-348.
Published: 01 April 1978
...L. A. Turnberg © 1978 The Biochemical Society and the Medical Research Society 1978 intestine intestine sodium transport Clinical Science and Molecular Medicine (1978) 54,337-348 EDITORIAL REVIEW Intestinal transport of salt and water L. A. TURNBERG Department of Medicine, Hope...
Articles
Clin Sci Mol Med (1978) 54 (4): 411-418.
Published: 01 April 1978
...M. L. G. Gardner; R. R. Samson; R. C. Heading 1. Glucose absorption, water absorption and dipeptide hydrolase activities have been determined in isolated rat small intestine at 1, 3, 5 and 21 days after a single intraperitoneal injection of 5-fluorouracil. 2. Absorption rates and enzyme activities...
Articles
Clin Sci Mol Med (1977) 53 (1): 35-43.
Published: 01 July 1977
... used to assess the toxicity of the carbohydrase-treated gliadin. 3. Gliadin treated with carbohydrases did not damage the intestinal mucosa of the coeliac patients. 4. The primary structure of the gliadin proteins was not altered by the enzyme treatment. 2 11 1976 2 2 1977 © 1977 The...
Articles
Clin Sci Mol Med (1977) 52 (6): 607-614.
Published: 01 June 1977
... free amino acid. This reflux of glycine and proline was not proportional to their concentrations in the mucosa. 2 8 1976 14 2 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 absorption glycine glycyl-l-proline intestine peptide Clinical Science...
Articles
Clin Sci Mol Med (1976) 51 (5): 427-433.
Published: 01 November 1976
...Elwyn Elias; R. H. Dowling 1. To study the relative contributions of luminal nutrition, bile and pancreatic secretions and hormonal factors in intestinal adaptation, lactation hyperphagia was chosen as a model for increased luminal nutrition, either alone (intestinal transection control group) or...
Articles
Clin Sci Mol Med (1976) 50 (6): 499-509.
Published: 01 June 1976
...R. M. Batt; T. J. Peters 1. The absorption in vivo of d-galactose by the rat small intestine has been examined in proximal jejunum and distal ileum by use of a recirculation—perfusion technique. 2. Multiple sequential perfusions over 4 h produced no subsequent functional or morphological damage in...
Articles
Clin Sci Mol Med (1976) 50 (6): 511-523.
Published: 01 June 1976
... Society 1976 absorption corticosteroids enterocyte enzymology galactose ileum intestine jejunum kinetics morphology phlorrhizin prednisolone Clinical Science and Molecular Medicine (1976) 50, 51 1-523. Effects of prednisolone on the small intestinal mucosa of the rat R. M. BATT AND T...
Articles
Clin Sci Mol Med (1976) 50 (5): 355-366.
Published: 01 May 1976
... 1975 © 1976 The Biochemical Society and the Medical Research Society 1976 brush borders cytosol enterocytes intestine liver lysosomes microsomes mitochondria peroxisomes subcellular fractionation Clinical Science and Molecular Medicine (1976) 50, 355-366. Analytical subcellular...
Articles
Clin Sci (1972) 43 (1): 101-114.
Published: 01 July 1972
... reaction that continues to generate unionized ammonia. 18 2 1972 © 1972 The Biochemical Society and the Medical Research Society 1972 faeces colon intestine pH ammonia bicarbonate absorption Clinical Science (1972) 43, 101-114. THE INTERRELATIONS O F FAECAL AMMONIA, pH AND...
Articles
Clin Sci (1972) 42 (1): 105-112.
Published: 01 January 1972
...J. D. Swales; J. D. Tange; D. J. Evans 1. The effects of intestinal ammonia in uraemia have been studied by administering a urease inhibitor, acetohydroxamic acid, to bilaterally nephrectomized rats. 2. Ammonia concentration was significantly decreased in the colon although it remained slightly...