... across cell membranes after alkali administration, leading to the phenomenon of ‘paradoxical’ intracellular acidosis, has been held responsible for some of these adverse effects. 2. Changes in intracellular pH in suspensions of leucocytes from healthy volunteers were monitored using a fluorescent...

... and hypertension) is present in cells from non-insulin-dependent diabetes patients with microalbuminuria, a known risk factor for cardiovascular and renal disease, is unknown. We therefore examined intracellular pH and calcium changes after acute exposure to insulin and angiotensin II in cultured skin fibroblasts...

...J. E. Davies; L. L. Ng 1. Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by simvastatin leads to inhibition of both cell growth and Na + /H + antiport activity. The effect of simvastatin on intracellular pH and Na + /H + antiport activity was therefore studied on an adherent cell line...

...Campbell H. Thompson; Paul D. Syme; E. Mark Williams; John G. G. Ledingham; George K. Radda 1. The effect of bicarbonate administration on the intracellular pH of rat skeletal muscle was examined by using 31 P n.m.r. 2. Bicarbonate administered intraperitoneally caused a significant intracellular...

...Ashley S. Izzard; David H. MacIver; Edward J. Cragoe; Anthony M. Heagerty 1. In order to examine the effects of experimental hypertension on intracellular pH in mesenteric resistance arteries, intracellular pH was measured in mesenteric resistance arteries from rats with coarctation 72 h, 9 days...

...D. J. A. Goldsmith; L. Poston; M. Watson; J. Morris; P. J. Hilton; E. J. Cragoe 1. Leucocyte Na + /H + exchange and intracellular pH were investigated in physiological buffer containing bicarbonate. 2. The amiloride analogue 5-( N,N -hexamethylene) amiloride (1 × 10 −5 mol/l), an inhibitor of Na...

...T. A. D. Cadoux-Hudson; B. Rajagopalan; J. G. G. Ledingham; G. K. Radda 1. The aim of this investigation was to measure the change in intracellular pH of human brain in vivo in response to hypercapnia. 2. Five healthy male subjects inspired air for 20 min and then 5% CO 2 /95% O 2 for 30 min...

... is present. Key words: acid-base balance, chronic obstructive lung disease, intracellular bicarbonate, intracellular pH, magnesium, muscle metabolism, potassium, sodium. Abbreviations: ARF, acute respiratory failure; [Cl-I,, extracellular [chloride] (mmol/l of extracellu- lar water); [Cl-1, intracellular...

...-7.1 to about 6.8 after 2 h occlusion. Muscle pH was essentially normalized within 20 min after restoration of the blood flow. energy metabolism intracellular pH ischaemia knee operation skeletal muscle 31 12 1984 3 1 1985 © 1985 The Biochemical Society and the Medical...

... skeletal buffering of non-volatile acids produced endogenously in nephrectomized rats. 25 7 1978 5 2 1979 © 1979 The Biochemical Society and the Medical Research Society 1979 acidosis bone buffering colchicine diphosphonate intracellular pH Clinical Science (1979) 51,19-23...

... intracellular pH lactate Clinical Science and Molecular Medicine (1978) 55,183-188 Mechanism of the effect of varying Pco, on gluconeogenesis from lactate in the perfused rat liver R. A. ILES , P. G. BARON A N D R. D. C O H E N The Metabolic and Endocrine Unit, The London Hospital Medical College...

...P. G. Baron; R. A. Iles; R. D. Cohen 1. The effects of varying P co 2 on lactate uptake and intracellular pH (pH l ) were studied in the isolated rat liver perfused with differing concentrations of lactate. 2. In general, pH l and lactate uptake are inversely related to P co 2 , and pH l...

...K. Sahlin; A. Alvestrand; J. Bergström; E. Hultman 1. A method for measuring intracellular pH and bicarbonate concentration of human muscle is described. 2. Muscle biopsies from the quadriceps muscle of 13 healthy subjects at rest were analysed for acid-labile carbon dioxide and volume of extra...

...G. E. Levin; D. N. Baron 1. Human leucocytes were isolated from venous blood and resuspended in the subject's plasma. 2. Intracellular pH measurements were made in vitro by the dimethyloxazolidinedione technique in 13 healthy subjects and in 11 subjects with renal failure and metabolic acidosis. 3...

...A. Tizianello; G. De Ferrari; G. Gurreri; N. Acquarone 1. Whole-body intracellular pH (pH 1 ) was measured by the 14 C-labelled DMO method in twenty-four control subjects, eighteen normal subjects with induced acute metabolic alkalosis, ten normal subjects with induced acute metabolic acidosis...

... Society 1975 ammonia extracellular pH intracellular pH brain Clinical Science and Molecular Medicine (1975) 48, 33-37. The distribution of ammonia between extracellular and intracellular compartments of the rat brain B. HIND FELT Department of Neurology and the Brain Research Laboratory...

...M. H. Lloyd; R. A. Iles; B. R. Simpson; J. M. Strunin; J. M. Layton; R. D. Cohen 1. The relationship between extracellular pH (pH e ), intracellular pH (pH i ) and lactate uptake was studied in the isolated perfused rat liver during simulated metabolic acidosis. 2. pH i fell to a considerably less...