... for the proliferation, migration and invasion of HCC cells without affecting apoptosis and necrosis, and PLD1 overexpression was sufficient to promote those effects. By using HCC xenograft models, we demonstrated that therapeutic inhibition of PLD1 attenuated tumour growth and epithelial–mesenchymal transition (EMT...

... and invasion, which was abrogated by miR-92b inhibition. Reversion-inducing, cysteine-rich protein with kazal motifs (RECK) was identified as the direct and functional target of miR-92b in osteosarcoma. Importantly, restoring RECK expression abrogated increases in cell growth, motility and invasiveness induced...

...Wei Gao; Jimmy Yu-Wai Chan; Thian-Sze Wong Curcumin suppresses proliferation, migration, invasion, metastasis and angiogenesis and induces apoptosis by regulating multiple signalling pathways and miRNAs in a wide variety of human malignancies. miRNAs play crucial roles in various steps...

...]. Initiation of invasive and metastatic cascades is triggered by degra- dation of basement membrane components by specific proteinases. Endothelin-1 (ET-1) is a peptide produced primarily by vascular cells and in elevated amounts by different cancer cells [2]. We have demonstrated pre- viously that ET-1...