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1-14 of 14
Keywords: iron
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (3): 219–237.
Published: 02 February 2023
...; however, genetic factors, host responses and infection also play an important role. Accumulating evidence highlights a role for iron dyshomeostasis and cellular iron accumulation in the lung as a key contributing factor in the development and pathogenesis of COPD. Recent studies have also shown...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (5): 503–524.
Published: 11 April 2006
...Joann M. McDermid; Andrew M. Prentice There are many lines of evidence illustrating that iron plays a pivotal role in modulating the battle for survival between mammalian hosts and their pathogens. Each displays considerable genetic investment in a wide range of mechanisms for acquiring...
Includes: Supplementary data
Articles
N. I. WEIJL, T. J. ELSENDOORN, R. M. W. MOISON, E. G. W. M. LENTJES, R. BRAND, H. M. BERGER, S. OSANTO
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (5): 475–484.
Published: 01 May 2004
...N. I. WEIJL; T. J. ELSENDOORN; R. M. W. MOISON; E. G. W. M. LENTJES; R. BRAND; H. M. BERGER; S. OSANTO Non-protein bound iron (NPBI) is able to catalyse oxidative reactions, causing damage to vital structures. Adverse effects induced by cisplatin seem, in part, to be mediated by free radicals...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (3): 239–247.
Published: 24 January 2001
...Mark J. BURKITT; Lesley MILNE; Alaeddin RAAFAT In the presence of ferrous ions (Fe 2+ ), the anti-tumour agent bleomycin will induce DNA degradation. Degradation of DNA into substances detectable by the thiobarbituric acid test has been used previously for the detection of iron in a form...
Articles
Graham P. Butcher, Nigel Deighton, Roger M. Batt, Boliang Ding, Susan Haywood, John Hoffman, Malcolm J. Jackson, Martyn C. R. Symons, Jonathan M. Rhodes
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (3): 339–348.
Published: 01 March 1993
... year period of dietary supplementation with alcohol, iron, or alcohol and iron. In alcohol-fed, iron-fed and alcohol- and iron-fed animals, mild histological damage was seen on light microscopy and evidence of mitochondrial and nuclear injury was identified by electron microscopy. 2. Subcellular...
Articles
Michele Matter, Tessa Stittfall, John Graves, Kathryn Myburgh, Brett Adams, Peter Jacobs, Timothy D. Noakes
Journal:
Clinical Science
Clin Sci (Lond) (1987) 72 (4): 415–422.
Published: 01 April 1987
...Michele Matter; Tessa Stittfall; John Graves; Kathryn Myburgh; Brett Adams; Peter Jacobs; Timothy D. Noakes 2 10 1986 24 10 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 blood lactate folate folate therapy iron iron therapy lactate turnpoint...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (6): 649–653.
Published: 01 June 1983
...D. A. Rowley; B. Halliwell 1. Superoxide and hydrogen peroxide are formed by activated phagocytes and react together in the presence of iron salts to form the hydroxyl radical, which attacks hyaluronic acid. Ascorbic acid also interacts with hydrogen peroxide and iron salts to form hydroxyl radical...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1983) 64 (5): 551–553.
Published: 01 May 1983
... that ferroxidase deficiency contributes to radical damage in the rheumatoid joint. 5 11 1982 16 12 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 caeruloplasmin synovial fluid rheumatoid arthritis iron ferroxidase Clinical Science (1983)64.551-553 SHORT...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (4): 321–325.
Published: 01 April 1980
...F. M. J. Zuyderhoudt; G. G. A. Jörning; J. G. De Haan; G. Samson; J. Van Gool 1. d-Galactosamine-HCl induces toxic hepatitis in the rat and was used as a model to study some aspects of iron metabolism during liver cell damage. Some changes in iron metabolism were similar to those encountered...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1978) 54 (1): 99–106.
Published: 01 January 1978
...M. J. Pippard; S. T. Callender; D. J. Weatherall 1. Urinary iron excretion after desferrioxamine has been examined in nine patients with different iron-loading anaemias. Particular attention has been paid to individual variation in response and the kinetics of iron removal in order to determine...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 53 (2): 111–115.
Published: 01 August 1977
... and may exert additional effects by promoting cytochrome P 450 turnover. 9 11 1976 7 2 1977 © 1977 The Biochemical Society and the Medical Research Society 1977 haem hexachlorobenzene iron porphyria Clinical Science and Molecular Medicine (1977) 53,111-1 15. Effects...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1977) 52 (5): 509–521.
Published: 01 May 1977
...H. L. Bonkowsky; Joanne S. Pomeroy 1. We have studied activity of δ-aminolaevulinate synthase in needle liver biopsy specimens obtained from 12 human cirrhotic subjects, five subjects who had ingested anticonvulsants and from control subjects. Liver iron concentrations and quantitative urinary...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1976) 50 (3): 145–152.
Published: 01 March 1976
...G. P. White; R. Bailey-Wood; A. Jacobs 1. The effect of iron chelators on iron uptake, ferritin and total protein synthesis was studied in cultured Chang cells. Desferrioxamine depressed ferritin synthesis and completely inhibited iron uptake by ferritin protein. Rhodotorulic acid reduced iron...
Articles
Journal:
Clinical Science
Clin Sci Mol Med (1975) 48 (5): 441–451.
Published: 01 May 1975
..., kidney or spleen ferritin. Reticulocyte ferritin appears to have similar characteristics to heart ferritin. 2. Serum ferritin from normal subjects and patients with various degrees of iron load, leukaemia or liver disease all have a much lower affinity for the anion-exchange column than any tissue...