... of the existing strong associations between iron overload and iron deficiency with cardiomyopathy. Free iron is highly-redox reactive and can participate in a redox reaction that leads to the generation of reactive oxygen species (ROS). ROS include not only a range of free radicals such as superoxide...

...Tomás Meroño; Fernando Brites; Carolane Dauteuille; Marie Lhomme; Martín Menafra; Alejandra Arteaga; Marcelo Castro; María Soledad Saez; Esteban González Ballerga; Patricia Sorroche; Jorge Rey; Philippe Lesnik; Juan Andrés Sordá; M. John Chapman; Anatol Kontush; Jorge Daruich Iron overload (IO) has...

.... 3. In the pancreas the level of pancreatitis-associated protein mRNA was also increased by alcohol and iron overload, but not by paracetamol. 4. In the small intestine expression of pancreatitis-associated protein mRNA was higher in normal ileum than in duodenum. In the ileum pancreatitis-associated...

...Sergio De Marchi; Emanuela Cecchin 1. A randomized, partial-crossover study was conducted in uraemic patients with dialysis-associated anaemia and transfusional iron overload to evaluate the effects of desferrioxamine chelation therapy and of recombinant human erythropoietin treatment on hepatic...

...M. Wagstaff; M. Worwood; A. Jacobs 1. The ferritin content of iron-overloaded tissues was higher than that of normal tissues. There was also an increased iron content of ferritin extracted from these tissues. 2. In the limited number of tissues that we examined haemosiderin deposition appeared...

...A. D. Heys; T. L. Dormandy 1. Iron-overloaded spleens from thalassaemic subjects showed a greatly increased susceptibility to free-radical oxidation (peroxidation) in vitro. 2. Iron content was the main but not the only variable governing susceptibility. Added ascorbate had a dose-dependent action...

... in the proportion of circulating ferritin which does not bind to concanavalin A. Such an increase has been found in sera from patients with iron overload. 30 5 1978 24 8 1978 © 1979 The Biochemical Society and the Medical Research Society 1979 concanavalin A ferritin serum ferritin...

... patients with iron overload than in those from other patient groups. 3. Lysosomes from the livers of patients with iron overload were strikingly more fragile than those of control subjects as demonstrated by assays of latent and sedimentable N -acetyl-β-glucosaminidase. 4. Lysosomal integrity...