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Keywords: ischaemia
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Articles

Does extracellular cardiac troponin I play a pathogenic role independently of autoantibodies?

Charles S. Redwood
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (24): 2277–2278.
https://doi.org/10.1042/CS20160493
Published: 10 November 2016
...Charles S. Redwood Cardiac troponin I (cTnI) is a key component of the Ca 2+ -regulatory mechanism of cardiac contractility. It is released into the circulation upon ischaemia and has become established as one of the principal diagnostic biomarkers of myocardial damage. The release of cTnI results...
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Articles

Protective actions of des-acylated ghrelin on brain injury and blood–brain barrier disruption after stroke in mice

Jacqueline M. Ku, Mohammadali Taher, Kai Yee Chin, Tom Barsby, Victoria Austin, Connie H.Y. Wong, Zane B. Andrews, Sarah J. Spencer, Alyson A. Miller
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (17): 1545–1558.
https://doi.org/10.1042/CS20160077
Published: 26 July 2016
... ischaemia/reperfusion-induced brain injury and swelling, and BBB disruption, by reducing oxidative and/or nitrosative damage. 2 2 2016 26 5 2016 13 6 2016 14 6 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 Stroke...
View article titled, Protective actions of des-acylated ghrelin on brain injury and blood–brain barrier disruption after stroke in mice
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Articles

The relevance of epigenetics to occlusive cerebral and peripheral arterial disease

Smriti Murali Krishna, Alexandra Fay Trollope, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (9): 537–558.
https://doi.org/10.1042/CS20140491
Published: 27 January 2015
... therapies for patients. These include the small therapeutic window in conditions such as acute stroke and critical limb ischaemia, since interventions introduced in such patients need to act rapidly and be safe in elderly patients with many co-morbidities. Pre-clinical animal experiments have also reported...
View article titled, The relevance of epigenetics to occlusive cerebral and peripheral arterial disease
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Articles

A novel vasculo-angiogenic effect of cilostazol mediated by cross-talk between multiple signalling pathways including the ERK/p38 MAPK signalling transduction cascade

Ting-Hsing Chao, Shih-Ya Tseng, Yi-Heng Li, Ping-Yen Liu, Chung-Lung Cho, Guey-Yueh Shi, Hua-Lin Wu, Jyh-Hong Chen
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (3): 147–159.
https://doi.org/10.1042/CS20110432
Published: 05 April 2012
... angiogenesis. In the present study, we have investigated the effect of cilostazol in promoting angiogenesis and vasculogenesis in a hindlimb ischaemia model and have also examined its potential mechanism of action in vitro and in vivo . We found that cilostazol treatment significantly increased colony...
View article titled, A novel vasculo-angiogenic effect of cilostazol mediated by cross-talk between multiple signalling pathways including the ERK/p38 MAPK signalling transduction cascade
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Articles

Inducible cardiac ischaemia is related to a decrease in the whole-blood Toll-like receptor 2 and 4 response

Ellen H. A. M. Elsenberg, Dik Versteeg, Jan-Willem Sels, Pieter-Jan J. Vlaar, Monique G. G. Hobbelink, Maarten-Jan M. Cramer, Dominique P. V. de Kleijn, René A. Tio, Bart J. G. L. de Smet, Pieter A. Doevendans, Imo E. Hoefer, Gerard Pasterkamp
Journal: Clinical Science
Clin Sci (Lond) (2012) 122 (11): 527–533.
https://doi.org/10.1042/CS20110323
Published: 10 February 2012
... is negatively correlated with fractional flow reserve, suggesting that chronic ischaemia can elicit an enhanced inflammatory response. In the present study, we assessed the association between leucocyte TLR-2 and TLR-4 responsiveness and pre-existent and inducible ischaemia in patients undergoing SPECT (single...
View article titled, Inducible cardiac <span class="search-highlight">ischaemia</span> is related to a decrease in the whole-blood Toll-like receptor 2 and 4 response
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Articles

Effect of ischaemic exercise training of a normal limb on angiogenesis of a pathological ischaemic limb in rabbits

Mei Shen, Jing Gao, Jianan Li, Juan Su
Journal: Clinical Science
Clin Sci (Lond) (2009) 117 (5): 201–208.
https://doi.org/10.1042/CS20080212
Published: 03 August 2009
... a 3 cm 2 square on the angiogram. The centre dot of the square was on the proximal end of femoral artery ligation sites. Three separate observers, blinded to the treatment regimen, counted the number of collaterals included within the square. angiogenesis collateralization ischaemia ischaemic...
View article titled, Effect of ischaemic exercise training of a normal limb on angiogenesis of a pathological ischaemic limb in rabbits
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Articles

Ischaemia and insulin, but not ischaemia and contraction, act synergistically in stimulating muscle glucose uptake in vivo in humans

Marlies Bosselaar, Paul Smits, Cees J. Tack
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (2): 157–164.
https://doi.org/10.1042/CS20080087
Published: 15 December 2008
...Marlies Bosselaar; Paul Smits; Cees J. Tack Ischaemia, like muscle contraction, has been reported to induce skeletal muscle glucose uptake in in vitro models. This stimulating effect appears independent of insulin and is probably mediated by activation of AMPK (AMP-activated protein kinase...
View article titled, <span class="search-highlight">Ischaemia</span> and insulin, but not <span class="search-highlight">ischaemia</span> and contraction, act synergistically in stimulating muscle glucose uptake in vivo in humans
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Articles

Is the mineralocorticoid receptor a potential target for stroke prevention?

Jessica M. Osmond, Christine' S. Rigsby, Anne M. Dorrance
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (1): 37–47.
https://doi.org/10.1042/CS20070155
Published: 30 November 2007
... 18 6 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 aldosterone collagen deposition epidermal growth factor receptor (EGFR) ischaemia mineralocorticoid receptor (MR) stroke vascular smooth muscle cell Stroke is a leading cause of morbidity...
View article titled, Is the mineralocorticoid receptor a potential target for stroke prevention?
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Articles

A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart

Kazuto Nakamura, Masataka Sata, Hiroshi Iwata, Yoshiki Sakai, Yasunobu Hirata, Kiyotaka Kugiyama, Ryozo Nagai
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (12): 607–616.
https://doi.org/10.1042/CS20060301
Published: 14 May 2007
... ameliorated left ventricular enlargement after 28 days and improved survival rate. In conclusion, our results indicate that ONO-1301 up-regulated endogenous growth factors and promoted angiogenesis in response to acute ischaemia. Therefore ONO-1301 might have a therapeutic potential in treating ischaemic...
View article titled, A synthetic small molecule, ONO-1301, enhances endogenous growth factor expression and augments angiogenesis in the ischaemic heart
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Articles

Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction

Jorge Berlanga, Danay Cibrian, Luis Guevara, Heberto Dominguez, Jose S. Alba, Alina Seralena, Gerardo Guillén, Ernesto López-Mola, Pedro López-Saura, Alberto Rodriguez, Brumny Perez, Diana Garcia, Nelson S. Vispo
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (4): 241–250.
https://doi.org/10.1042/CS20060103
Published: 17 January 2007
... quantitative histopathology, local IGF-I (insulin-growth factor-I) expression and oxidative stress markers. GHRP6 treatment did not have any influence on mortality during surgery associated with rhythm and conductance disturbances during ischaemia. Infarct mass and thickness were reduced by 78% and 50...
View article titled, Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction
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Articles

Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells

Minami Abe, Masataka Sata, Etsu Suzuki, Ryo Takeda, Masao Takahashi, Hiroaki Nishimatsu, Daisuke Nagata, Kenji Kangawa, Hisayuki Matsuo, Ryozo Nagai, Yasunobu Hirata
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (6): 381–387.
https://doi.org/10.1042/CS20060137
Published: 14 November 2006
... of adrenomedullin on collateral formation and circulating bone-marrow-derived cells after acute tissue ischaemia. Bone marrow of 8–10-week-old female C57BL/6J mice was replaced with that from GFP (green fluorescent protein) transgenic mice (GFP mice). At 8 weeks after transplantation, hindlimb ischaemia was induced...
View article titled, Effects of adrenomedullin on acute <span class="search-highlight">ischaemia</span>-induced collateral development and mobilization of bone-marrow-derived cells
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Articles

The endothelin-1 receptor antagonist bosentan protects against ischaemia/reperfusion-induced endothelial dysfunction in humans

Felix BÖHM, Magnus SETTERGREN, Adrian T. GONON, John PERNOW
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (4): 357–363.
https://doi.org/10.1042/CS20040317
Published: 22 March 2005
...Felix BÖHM; Magnus SETTERGREN; Adrian T. GONON; John PERNOW Endothelial dysfunction may contribute to the extent of ischaemia/reperfusion injury. ET (endothelin)-1 receptor antagonism protects against myocardial ischaemia/reperfusion injury in animal models. The present study investigated whether...
View article titled, The endothelin-1 receptor antagonist bosentan protects against <span class="search-highlight">ischaemia</span>&#x2F;reperfusion-induced endothelial dysfunction in humans
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Articles

B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke

Rajesh ULLEGADDI, Hilary J. POWERS, Salah E. GARIBALLA
Journal: Clinical Science
Clin Sci (Lond) (2004) 107 (5): 477–484.
https://doi.org/10.1042/CS20040134
Published: 26 October 2004
[email protected] ). 30 4 2004 21 7 2004 28 7 2004 28 7 2004 The Biochemical Society 2004 B-group vitamin C-reactive protein homocysteine ischaemia stroke malondialdehyde total antioxidant capacity Stroke is the third most common cause of death in most Western...
View article titled, B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke
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Articles

Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy

Yoshinori SEKO, Shuichi FUKUDA, Ryozo NAGAI
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (5): 439–442.
https://doi.org/10.1042/CS20030365
Published: 01 May 2004
... endothelial proliferation and suppress tumour growth. However, to date, little is known about the pathophysiology of endostatin in ischaemia/reperfusion. To investigate the mechanisms of angiogenesis induced by myocardial ischaemia/reperfusion in more detail, we studied the circulating levels of endostatin...
View article titled, Serum levels of endostatin, vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in patients with acute myocardial infarction undergoing early reperfusion therapy
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Articles

Haemodynamic insights into the effects of ischaemia and cycle length on tissue Doppler-derived mitral annulus diastolic velocities

Sherif F. NAGUEH, Liyun RAO, Julia SOTO, Katherine J. MIDDLETON, Dirar S. KHOURY
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (2): 147–154.
https://doi.org/10.1042/CS20030204
Published: 01 February 2004
...Sherif F. NAGUEH; Liyun RAO; Julia SOTO; Katherine J. MIDDLETON; Dirar S. KHOURY In the present study, we performed simultaneous epicardial echocardiography and left heart catheterization on ten adult dogs to investigate the effects of ischaemia and tachycardia on the mitral annulus early (E...
View article titled, Haemodynamic insights into the effects of <span class="search-highlight">ischaemia</span> and cycle length on tissue Doppler-derived mitral annulus diastolic velocities
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Articles

Dobutamine induces ineffective work in regional ischaemic myocardium: an experimental strain rate imaging study

Frank WEIDEMANN, Jens BROSCHEIT, Nicole EBERBACH, Paul STEENDIJK, Wolfram VOELKER, Clemens GREIM, Georg ERTL, Norbert ROEWER, Jörg M STROTMANN
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (2): 173–181.
https://doi.org/10.1042/CS20030109
Published: 01 February 2004
... and regional ischaemia of the posterior wall. These parameters were compared with global contractility [E ES (end-systolic elastance)] measured by a conductance catheter. Ischaemia was induced by an active coronary hypoperfusion in the circumflex coronary artery. Measurements were done at baseline, during...
View article titled, Dobutamine induces ineffective work in regional ischaemic myocardium: an experimental strain rate imaging study
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Articles

Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: favourable effect of muscle activity

Malgorzata MILKIEWICZ, Olga HUDLICKA, Julie VERHAEG, Stuart EGGINTON, Margaret D. BROWN
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (4): 473–482.
https://doi.org/10.1042/CS20030035
Published: 01 October 2003
... of Sprague—Dawley rats were studied at 1, 2 and 5 week intervals after iliac artery ligation. Muscle VEGF protein levels (as determined by Western-blot analysis) increased only after 2 (60%) and 5 (80%) weeks, with more capillaries positively immunostained for VEGF than in control muscles. Ischaemia-induced...
View article titled, Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic <span class="search-highlight">ischaemia</span>: favourable effect of muscle activity
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Articles

Differential effects of endothelin-1 on isolated working rat hearts before and after ischaemia and reperfusion

Andrew T. GOODWIN, Mohamed AMRANI, Caroline C. GRAY, Jay JAYAKUMAR, Adrian J. MARCHBANK, Magdi H. YACOUB
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 189S–193S.
https://doi.org/10.1042/CS103S189S
Published: 01 September 2002
...Andrew T. GOODWIN; Mohamed AMRANI; Caroline C. GRAY; Jay JAYAKUMAR; Adrian J. MARCHBANK; Magdi H. YACOUB Endothelin (ET) may have both detrimental (reduced coronary flow) and beneficial effects (positive inotrope, reduced arrhythmogenesis) following ischaemia. We examined the effects of ET...
View article titled, Differential effects of endothelin-1 on isolated working rat hearts before and after <span class="search-highlight">ischaemia</span> and reperfusion
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Articles

Pericardial concentrations of adenosine, inosine and hypoxanthine in an experimental canine model of spastic ischaemia

Violetta KÉKESI, Endre ZIMA, Erzsébet BARÁT, Éva HUSZÁR, Andrea NAGY, László LOSONCZI, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 198S–201S.
https://doi.org/10.1042/CS103S198S
Published: 01 September 2002
... plasma. A further increase in the pericardial adenosine concentration was also demonstrated in myocardial ischaemia or hypoxia. It was proposed that pericardial nucleoside levels may represent the interstitial concentrations of the adenine nucleosides. An experimental model was designed to determine...
View article titled, Pericardial concentrations of adenosine, inosine and hypoxanthine in an experimental canine model of spastic <span class="search-highlight">ischaemia</span>
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Articles

Endothelin-1-induced elevations in purine metabolite concentrations — autoregulatory protection in the canine pericardium?

Endre ZIMA, Violetta KÉKESI, Andrea NAGY, László LOSONCZI, Ildikó TOMA, Pál SOÓS, Erzsébet Barát, Éva HUSZÁR, Béla MERKELY, Ferenc HORKAY, Alexander Juhász-Nagy
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 202S–205S.
https://doi.org/10.1042/CS103S202S
Published: 01 September 2002
... with C2, while the endocardial monophasic action potential duration and upstroke velocity did not show ischaemia-related changes. The results suggest that intrapericardial administration of ET-1 induces subepicardial ischaemia, with parallel activation of coronary metabolic adaptive and cardiac self...
View article titled, Endothelin-1-induced elevations in purine metabolite concentrations — autoregulatory protection in the canine pericardium?
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Articles

Pathophysiological roles of Ca 2+ overload via the Na + /Ca 2+ exchanger and endothelin-1 overproduction in ischaemia/reperfusion-induced acute renal failure

Yasuo MATSUMURA, Junji YAMASHITA, Satomi KITA, Takahiro IWAMOTO, Masaya OGATA, Masanori TAKAOKA, Koji WAKIMOTO, Munekazu SHIGEKAWA, Issei KOMURO
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 389S–392S.
https://doi.org/10.1042/CS103S389S
Published: 01 September 2002
... in ischaemia/reperfusion-induced renal injury was investigated. Since NCX1 -/- homozygous mice die of heart failure before birth, we utilized NCX1 +/- heterozygous mice. The ischaemia/reperfusion-induced renal dysfunction in heterozygous mice were significantly attenuated compared with cases in wild-type mice...
View article titled, Pathophysiological roles of Ca 2+ overload via the Na + &#x2F;Ca 2+ exchanger and endothelin-1 overproduction in <span class="search-highlight">ischaemia</span>&#x2F;reperfusion-induced acute renal failure
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Articles

Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction

Masanori TAKAOKA, Mikihiro YUBA, Toshihide FUJII, Mamoru OHKITA, Yasuo MATSUMURA
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 434S–437S.
https://doi.org/10.1042/CS103S434S
Published: 01 September 2002
... clearance were measured to test the effectiveness of the steroid hormone. Renal function in ARF rats markedly decreased 24h after reperfusion. The ischaemia/reperfusion-induced renal dysfunction was dose-dependently improved by pretreatment with 17β-oestradiol (20 or 100 µ g/kg, intravenously...
View article titled, Oestrogen protects against ischaemic acute renal failure in rats by suppressing renal endothelin-1 overproduction
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Articles

Assessment of regional long-axis function during dobutamine echocardiography

Peter CAIN, Thomas H. MARWICK, Colin CASE, Terri BAGLIN, Jared DART, Leanne SHORT, Bjorn OLSTAD
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (4): 423–432.
https://doi.org/10.1042/cs1000423
Published: 09 March 2001
... ischaemia left ventricle long axis stress echocardiography 423Clinical Science (2001) 100, 423 432 (Printed in Great Britain) Assessment of regional long-axis function during dobutamine echocardiography Peter CAIN, Thomas H. MARWICK, Colin CASE, Terri BAGLIN, Jared DART, Leanne SHORT and Bjorn OLSTAD...
View article titled, Assessment of regional long-axis function during dobutamine echocardiography
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Articles

Characterization of an in vitro model for the study of the short and prolonged effects of myocardial ischaemia and reperfusion in man

Jin-Gang ZHANG, Sudip GHOSH, Colin D. OCKLEFORD, Manuel GALIÑANES
Journal: Clinical Science
Clin Sci (Lond) (2000) 99 (5): 443–453.
https://doi.org/10.1042/cs0990443
Published: 27 October 2000
...Jin-Gang ZHANG; Sudip GHOSH; Colin D. OCKLEFORD; Manuel GALIÑANES The mechanisms underlying myocardial ischaemia and reperfusion-induced injury have been investigated, mainly by using animal experimental preparations in vitro and in vivo , but little is known of the process in human myocardium...
View article titled, Characterization of an in vitro model for the study of the short and prolonged effects of myocardial <span class="search-highlight">ischaemia</span> and reperfusion in man
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Articles

Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes

Christopher J. CHARLES, John M. ELLIOTT, M. Gary NICHOLLS, Miriam T. RADEMAKER, Mark RICHARDS
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (6): 703–711.
https://doi.org/10.1042/cs0980703
Published: 10 May 2000
... of heart failure is increasing in Western countries, with hospital admission rates continuing to rise during the past two decades [1]. Despite recent Key words : experimental, haemodynamics, heart, heart failure, ischaemia, pathophysiology, reperfusion. Abbreviations : ANP, atrial natriuretic peptide ; BNP...
View article titled, Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes
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Articles

Function of Rat Skeletal Muscles after Storage at 10°C in Various Preservation Solutions

E. P. A. van der Heijden, A. B. A. Kroese, P. M. N. Werker, P. D. Grabietz, M. B. De Jong, P. R. Bär, M. Kon
Journal: Clinical Science
Clin Sci (Lond) (1998) 94 (3): 271–278.
https://doi.org/10.1042/cs0940271
Published: 01 March 1998
... of the solutions used. Both UW and HTK were most effective ( P 0 > 50% of control) in preserving muscle function. 27 10 1997 27 10 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 direct electrical stimulation ischaemia isolated muscle muscle contractility...
View article titled, Function of Rat Skeletal Muscles after Storage at 10°C in Various Preservation Solutions
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Articles

Suppression of Oxidant Production by Diltiazem, Nifedipine and Verapamil in Human Neutrophils

Y.-H. Feng, G. Hart
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (4): 459–466.
https://doi.org/10.1042/cs0910459
Published: 01 October 1996
...Y.-H. Feng; G. Hart 1. Polymorphonuclear leucocytes are a major source of toxic oxidants in vivo , causing tissue injury in certain circumstances such as ischaemia and reperfusion. Calcium ions are a key mediator in the production of oxidants by these cells. The aim of this study was to examine...
View article titled, Suppression of Oxidant Production by Diltiazem, Nifedipine and Verapamil in Human Neutrophils
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Articles

Non-Invasive Measurement of Cardiac Oxygenation and Haemodynamics during Transient Episodes of Coronary Artery Occlusion and Reperfusion in the Pig

M. S. Thorniley, A. Lahiri, B. Glenville, C. Shurey, G. Baker, U. Ravel, J. Crawley, C. J. Green
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (1): 51–58.
https://doi.org/10.1042/cs0910051
Published: 01 July 1996
... descending coronary artery occlusion was induced to produce periods of ischaemia lasting between 24 s and 13.5 min ( n = 13). The changes in deoxyhaemoglobin, oxyhaemoglobin and cytochrome aa 3 measured during occlusion were all highly significant compared with baseline variation. In all occlusions ( n = 13...
View article titled, Non-Invasive Measurement of Cardiac Oxygenation and Haemodynamics during Transient Episodes of Coronary Artery Occlusion and Reperfusion in the Pig
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Articles

New Insights into Myocardial Arrhythmogenesis: Distribution of Gap-Junctional Coupling in Normal, Ischaemic and Hypertrophied Human Hearts

Nicholas S. Peters
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (6): 447–452.
https://doi.org/10.1042/cs0900447
Published: 01 June 1996
... be expected to influence myocardial conduction and the arrhythmogenic substrate. © 1996 The Biochemical Society and the Medical Research Society 1996 connexin43 gap junction myocardium human ischaemia hypertrophy Clinical Science (1996) 90, 447452 (Printed in Great Britain) 447 Glaxo/M RS...
View article titled, New Insights into Myocardial Arrhythmogenesis: Distribution of Gap-Junctional Coupling in Normal, Ischaemic and Hypertrophied Human Hearts
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Articles

Is Allopurinol Beneficial in the Prevention of Renal Ischaemia—Reperfusion Injury in the Rat?: Evaluation by Near-Infrared Spectroscopy

D. L. Vaughan, Y. A. B. D. Wickramasinghe, G. I. Russell, M. S. Thorniley, R. F. Houston, E. Ruban, P. Rolfe
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (3): 359–364.
https://doi.org/10.1042/cs0880359
Published: 01 March 1995
...D. L. Vaughan; Y. A. B. D. Wickramasinghe; G. I. Russell; M. S. Thorniley; R. F. Houston; E. Ruban; P. Rolfe 1. The role of allopurinol in the protection of kidney function following ischaemia—reperfusion injury has been investigated using the novel technique of near-infrared spectroscopy. 2...
View article titled, Is Allopurinol Beneficial in the Prevention of Renal <span class="search-highlight">Ischaemia</span>—Reperfusion Injury in the Rat?: Evaluation by Near-Infrared Spectroscopy
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Articles

Enhancement of ischaemic rabbit skin flap survival with the antioxidant and free-radical scavenger N -acetylcysteine

Kenneth R. Knight, Karen MacPhadyen, Diana A. Lepore, Noriyuki Kuwata, Patricia A. Eadie, Bernard McC. O'Brien
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (1): 31–36.
https://doi.org/10.1042/cs0810031
Published: 01 July 1991
... intravenous treatment. The possible clinical benefits in humans have yet to be demonstrated. 21 1 1991 28 1 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 N -acetylcysteine antioxidant free-radical scavenger ischaemia skin flap thromboxane Clinical...
View article titled, Enhancement of ischaemic rabbit skin flap survival with the antioxidant and free-radical scavenger N -acetylcysteine
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Articles

Effect of Phosphate-Buffered Sucrose Flush Solution upon the Initial Phase of Ischaemic Acute Renal Failure in the Rat

O. S. Ferwana, S. C. Pirie, D. J. Potts
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (1): 77–84.
https://doi.org/10.1042/cs0770077
Published: 01 July 1989
... compositions. 2. Kidneys flushed with PB immediately before 45 min pedicle clamp ischaemia exhibited a post-ischaemic function similar to that of control, non-flushed kidneys: they were isosthenuric and non-oliguric with a clearance of inulin ( C in ) depressed to 10% of the pre-ischaemic value. 3. Kidneys...
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Articles

Unilateral renal ischaemia in the rat: Effect of contralateral nephrectomy and intrarenal flush with phosphate-buffered sucrose

O. S. Ferwana, S. C. Pirie, D. J. Potts
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (3): 261–268.
https://doi.org/10.1042/cs0740261
Published: 01 March 1988
...-buffered sucrose (PBS50) solution. 2. After ischaemia, unflushed kidneys became oliguric and isosthenuric, with a fall in inulin clearance ( C in ) to 0.1% of the pre-ischaemic value. Removal of the healthy contralateral kidney upon release of the occlusion caused no improvement in immediate post-ischaemic...
View article titled, Unilateral renal <span class="search-highlight">ischaemia</span> in the rat: Effect of contralateral nephrectomy and intrarenal flush with phosphate-buffered sucrose
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Articles

Origins of endogenous noradrenaline overflow during reperfusion of the ischaemic rat heart

A. M. Dart, R. A. Riemersma
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (3): 269–274.
https://doi.org/10.1042/cs0740269
Published: 01 March 1988
...A. M. Dart; R. A. Riemersma 1. Reperfusion of the globally ischaemic isolated rat heart is associated with an enhanced overflow of endogenous noradrenaline (NA) after ischaemic periods of 20, 40 or 60 min but not of 10 min. 2. Reperfusion NA overflow, after 40 min of ischaemia, is suppressed...
View article titled, Origins of endogenous noradrenaline overflow during reperfusion of the ischaemic rat heart
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Articles

AMP deaminase deficiency: Study of the human skeletal muscle purine metabolism during ischaemic isometric exercise

S. P. T. Sinkeler, R. A. Binkhorst, E. M. G. Joosten, R. A. Wevers, M. M. Coerwinkel, T. L. Oei
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (4): 475–482.
https://doi.org/10.1042/cs0720475
Published: 01 April 1987
... of AMPD activity in the adenine nucleotide catabolism of skeletal muscle. 24 10 1986 14 11 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 AMP deaminase exercise ischaemia muscle purines CIinicalScience( 1987) 72,475-482 475 AMP deaminase deficiency...
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Articles

Enhancement of cardiac vagal action during ischaemia of the sino-atrial node

Erica K. Potter, D. I. McCloskey, Gillian P. Courtice
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (4): 449–451.
https://doi.org/10.1042/cs0710449
Published: 01 October 1986
...Erica K. Potter; D. I. McCloskey; Gillian P. Courtice 1. The effect of ischaemia of the sino-atrial node on cardiac vagal action was studied in anaesthetized dogs. 2. The cut, cardiac end of the right vagus nerve was stimulated with a standard supramaximal stimulus every 10 s. The arterial supply...
View article titled, Enhancement of cardiac vagal action during <span class="search-highlight">ischaemia</span> of the sino-atrial node
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Articles

Biochemical and Morphometric Properties of Mitochondrial Populations in Human Muscle Fibres

Anna Elander, Michael Sjöström, Fredrik Lundgren, Tore Scherstén, Ann-Christin Bylund-Fellenius
Journal: Clinical Science
Clin Sci (Lond) (1985) 69 (2): 153–163.
https://doi.org/10.1042/cs0690153
Published: 01 August 1985
... mitochondrial populations and a qualitative improvement of the respiratory activity of the subsarcolemmal mitochondria. 8 2 1985 26 2 1985 © 1985 The Biochemical Society and the Medical Research Society 1985 citrate synthase exercise ischaemia mitochondria oxidative phosphorylation...
View article titled, Biochemical and Morphometric Properties of Mitochondrial Populations in Human Muscle Fibres
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Articles

The effect of long-term circulatory occlusion on pH and energy metabolism of the quadriceps muscle in man

H. Sjöholm, A. Gidlöf, J. Larsson, K. Sahlin
Journal: Clinical Science
Clin Sci (Lond) (1985) 68 (5): 597–600.
https://doi.org/10.1042/cs0680597
Published: 01 May 1985
...-7.1 to about 6.8 after 2 h occlusion. Muscle pH was essentially normalized within 20 min after restoration of the blood flow. energy metabolism intracellular pH ischaemia knee operation skeletal muscle 31 12 1984 3 1 1985 © 1985 The Biochemical Society and the Medical...
View article titled, The effect of long-term circulatory occlusion on pH and energy metabolism of the quadriceps muscle in man
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Articles

Uptake of Inactive Renin by Human Ischaemic Kidney

I. M. McKenzie, E. Reisin, J. K. McKenzie
Journal: Clinical Science
Clin Sci (Lond) (1983) 65 (1): 27–32.
https://doi.org/10.1042/cs0650027
Published: 01 July 1983
... sodium intake. 2. Whether inactive renin was activated by acid or trypsin, it tended to be increased by 50–100% in unilateral renal ischaemia patients compared with essential hypertension. Active renin was increased two- to four-fold in unilateral renal ischaemia patients compared with those...
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Articles

The Effect of Adrenaline on Hepatic Lactate Uptake in the Acidotic Partially Ischaemic Rat Liver

R. A. Iles, R. D. Cohen, P. G. Baron, J. A. Smith, R. M. Henderson
Journal: Clinical Science
Clin Sci (Lond) (1981) 60 (5): 543–548.
https://doi.org/10.1042/cs0600543
Published: 01 May 1981
... exercise hepatic gluconeogenesis ischaemia lactic acidosis Clinical Science (1981)60, 543-548 The effect of adrenaline on hepatic lactate uptake in the acidotic partially ischaemic rat liver R. A. ILES, R. D. COHEN, P. G. BARON, J. A. SMITH AND R. M. HENDERSON Metabolic and Endocrine Unit, The London...
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Articles

The Effect of Adrenaline-Induced Endogenous Lipolysis upon the Mechanical and Metabolic Performance of Ischaemically Perfused Rat Hearts

R. W. Brownsey, R. V. Brunt
Journal: Clinical Science
Clin Sci Mol Med (1977) 53 (6): 513–521.
https://doi.org/10.1042/cs0530513
Published: 01 December 1977
...R. W. Brownsey; R. V. Brunt 1. The isolated perfused non-working rat heart, subjected to low coronary flow, has been used to study the effects of myocardial ischaemia on both the mechanical and metabolic performance of the heart. 2. In this preparation, adrenaline initially increased developed...
View article titled, The Effect of Adrenaline-Induced Endogenous Lipolysis upon the Mechanical and Metabolic Performance of Ischaemically Perfused Rat Hearts
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