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Keyword: ischaemia/reperfusion
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Articles
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... RES. It is known that RES is an autophagic enhancer and exerts a cardioprotective effect against ischaemia/reperfusion (I/R) injury. However, the effect of PD post-treatment on myocardial I/R injury remains unclear. In the present study, we investigated the influences of PD post-treatment on...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (9): 645–659.
Published: 14 January 2014
... role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and urea levels ( P <0.01) in patients with AKI, which then fell after recovery from AKI. To determine the role of CRP in AKI, an ischaemia/reperfusion mouse model of AKI was...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 124 (1): 1–15.
Published: 07 September 2012
... experimental studies have demonstrated that oxidative stress plays a major role in heart ischaemia/reperfusion pathophysiology, controlled clinical trials have failed to prove the efficacy of antioxidants in acute or long-term treatments of ischaemic heart disease. Oral doses of vitamin C are not sufficient to...
Articles
Clin Sci (Lond) (2012) 123 (2): 93–98.
Published: 23 March 2012
... (ischaemia/reperfusion) injury in the liver. I/R is the main cause of primary liver failure and, consequently, minimizing the detrimental effects of this process could increase the number of suitable transplantation grafts and also enhance the survival rate of patients after liver transplantation. A...
Articles
Clin Sci (Lond) (2012) 123 (1): 39–51.
Published: 12 March 2012
.... number of VPB (ventricular premature beats) during occlusion 294±78 compared with 63±25; survival from the combined ischaemia/reperfusion insult 20% compared with 78%], and in other ischaemic changes [epicardial ST-segment, TAT (total activation time) and tissue impedance]. Pacing also prevented the...
Articles
Clin Sci (Lond) (2012) 122 (7): 329–336.
Published: 07 December 2011
... unknown. We examined whether the erythropoietin analogue darbepoetin improves FMD (flow-mediated dilatation), a measure of endothelium-derived NO, and whether this is influenced by preceding I/R (ischaemia/reperfusion). A total of 36 patients (50–75 years) with stable coronary artery disease were...
Articles
Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
...Narci C. Teoh Hepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR...
Articles
Clin Sci (Lond) (2011) 121 (6): 257–266.
Published: 27 May 2011
...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...
Articles
Clin Sci (Lond) (2011) 121 (1): 1–10.
Published: 18 March 2011
... expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
Articles
Clin Sci (Lond) (2009) 117 (9): 339–344.
Published: 01 September 2009
... bo.westman@sns.sll.se ). 11 12 2008 26 3 2009 30 3 2009 30 3 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 amino acid glutathione ischaemia/reperfusion lactate liver resection surgery Warm ischaemia with subsequent reperfusion is a potent...
Articles
Clin Sci (Lond) (2008) 115 (11): 335–342.
Published: 03 November 2008
... against IR (ischaemia/reperfusion) injury. Adenovirus-mediated HO-1 gene transfer (Adv-HO-1) was carried out by injection into the vitreous body to induce HO-1 overexpression. At 3 weeks after transfection, levels of HO-1 expression, as measured by Western blot analysis, immunohistochemical staining and...
Articles
Clin Sci (Lond) (2008) 115 (2): 69–77.
Published: 12 June 2008
...Hussam H. Ajamieh; Eduardo Candelario-Jalil; Olga Sonia León Fernández; Alexander L Gerbes Although IPC (ischaemic preconditioning) is considered as a protective strategy in HI/R (hepatic ischaemia/reperfusion), the mechanisms for this effect have not been fully elucidated. In the present study we...
Articles
Clin Sci (Lond) (2008) 114 (8): 553–560.
Published: 13 March 2008
...Marcel C. G. van de POLL; Cornelis H. C. Dejong; Marc A. J. G. Fischer; Aalt Bast; Ger H. Koek Oxidative stress mediates cell injury during ischaemia/reperfusion. On the other hand, experimental findings suggest that ROS (reactive oxygen species) induce processes leading to ischaemic...
Articles
Clin Sci (Lond) (2007) 113 (7): 313–318.
Published: 03 September 2007
...@sts.sll.se ). 11 1 2007 5 4 2007 2 5 2007 2 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 amino acid energy-rich compound glutathione ischaemia/reperfusion knee replacement surgery skeletal muscle The metabolic effects of ischaemia and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2006) 110 (5): 563–573.
Published: 11 April 2006
... examined its efficacy when given alone and in combination with the potent protective factor EGF (epidermal growth factor) in an in vivo model of MOF (using two hepatic vessel ischaemia/reperfusion protocols; 45 min of ischaemia and 45 min of reperfusion or 90 min of ischaemia and 120 min of reperfusion...
Articles
Clin Sci (Lond) (2005) 109 (1): 117–123.
Published: 23 June 2005
... Reconstructive Surgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands (email jbas@spch.azm.nl ). 2 6 2004 1 12 2004 21 12 2004 21 12 2004 The Biochemical Society 2005 hypothermia ischaemia/reperfusion microcirculation muscle perfusion preservation...
Articles
Clin Sci (Lond) (2005) 108 (1): 47–53.
Published: 15 December 2004
...Kenneth R. KNIGHT; Trixie A. SHINKEL; Peter J. COWAN; Rosalind ROMEO-MEEUW; Anthony J. F. d'APICE; Wayne A. MORRISON This study aimed to explore the hypothesis that activated complement components contribute significantly to I/R (ischaemia/reperfusion) injury in skeletal muscle. After 50, 70 and 90...
Articles
Clin Sci (Lond) (2004) 107 (5): 497–503.
Published: 26 October 2004
...Ruksana HUDA; Daneshvari R. SOLANKI; Mali MATHRU The objective of this study was to identify cellular and plasma marker(s) of post-I/R (ischaemia/reperfusion) in patients undergoing elective knee surgery where a tourniquet was used to facilitate a bloodless surgical field. We evaluated the...
Articles
Clin Sci (Lond) (2003) 105 (3): 287–294.
Published: 01 September 2003
...Kou-Gi SHYU; Chih-Chuan CHANG; Bao-Wei WANG; Peiliang KUAN; Hang CHANG The angiopoietins and Tie receptors are involved in blood vessel formation. The role of the angiopoietin/Tie receptor system in myocardial ischaemia/reperfusion is not well known. To investigate the participation of...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 59S–63S.
Published: 01 September 2002
...Terézia B. ANDRÁSI; Violetta KÉKESI; Anna BLÁZOVICS; István DÓBI; Gábor SZABÂ; Alexander JUHÁSZ-NAGY The aim of the present study was to determine whether the ET A receptor antagonist LU135252 can protect the mesenterium against ischaemia/reperfusion (I/R) damage. Direct occlusion of the superior...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 223S–227S.
Published: 01 September 2002
... (not significantly different). The incidence of non-sustained and sustained ventricular tachycardias during ischaemia, reperfusion and over the whole period (ischaemia plus reperfusion) in the control group was 50%, 50% and 70% respectively, and that in the LU group was 80%, 70% and 100% respectively...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 206S–209S.
Published: 01 September 2002
...Andrew T. GOODWIN; Mahboob A. KHAN; Adrian H. CHESTER; Mohamed AMRANI; Magdi H. YACOUB Endothelin-1 (ET-1) is believed to play an important role in cardiac ischaemia/reperfusion injury. ET-1 is synthesized from preproET-1 by the action of ET-converting enzyme (ECE). It is unclear to what extent the...
Articles
Clin Sci (Lond) (2002) 102 (5): 579–586.
Published: 23 April 2002
...Alexander M. SEIFALIAN; Hamid EL-DESOKY; David T. DELPY; Brian R. DAVIDSON Hepatic ischaemia/reperfusion (I/R) injury is a major cause of primary non-function of the graft after liver transplantation. The ability to assess the severity of ischaemic injury would be of prognostic value and allow the...