...Yan Wang; Haobo Li; Huansen Huang; Shiming Liu; Xiaowen Mao; Sheng Wang; Stanley Sau-ching Wong; Zhengyuan Xia; Michael G. Irwin Isoflurane postconditioning (IsoPostC) attenuates myocardial ischaemia/reperfusion injury (IRI). Signal transducer and activator of transcription-3 (STAT3) is critical...

... disorders. However, its role in myocardial ischaemia/reperfusion injury (MIRI) remains unknown. The purpose of the present study was to determine whether Tregs exert a beneficial effect on mouse MIRI. We examined the role of Tregs in murine MIRI by depletion using ‘depletion of regulatory T-cell’ (DEREG...

... by inducing the PHR (portal hypertensive response) via B 2 R, whereas DABK (des-Arg 9 -BK), a B 1 R agonist, does not elicit the response. During IRI (ischaemia/reperfusion injury), important changes occur in the microcirculation, and cell death by necrosis and apoptosis is involved in poor graft function...

... with myocardial infarct size. To verify further the relationship between myocardial size and miR-1 level, an IP (ischaemic preconditioning) model was used. The results showed that IP significantly reduced circulating miR-1 levels and myocardial infract size induced by I/R (ischaemia/reperfusion) injury. Finally...

... Biochemical Society 2010 fibrosis hepatocellular carcinoma ischaemia/reperfusion injury non-alcoholic fatty liver disease (NAFLD) nuclear factor κB (NF-κB) regeneration NF-κB (nuclear factor κB) was first described in 1986 as a nuclear transcription factor required for immunoglobulin kappa...

... pathophysiological mechanisms remain unclear. The FSL (Flinders Sensitive Line) rat is a genetic animal model of depression exhibiting features similar to those of depressed individuals. The aim of the present study was to compare the myocardial responsiveness to I/R (ischaemia/reperfusion) injury and the effects...

... 14 11 2007 14 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 cardiac ischaemia endothelin erythropoietin (EPO) ischaemia/reperfusion injury natriuretic peptide Cardiovascular disease is an important burden in the Western world, with a prevalence...

.... Correspondence: Dr Chris Pemberton (email [email protected] ). cardiac ischaemia endothelin erythropoietin (EPO) ischaemia/reperfusion injury natriuretic peptide EPO (erythropoietin), a glycoprotein growth factor produced by the kidneys, is an important regulator of red blood cell...

...Ismail H. Mallick; Marc C. Winslet; Alexander M. Seifalian IR (ischaemia/reperfusion) injury of the intestine occurs commonly during abdominal surgery. We have previously shown that PDTC (pyrrolidine dithiocarbamate), an HO-1 (haem oxygenase-1) donor, improves intestinal microvascular perfusion...

... [ 8 ]. In animal models, myocardial necrosis after ischaemia/reperfusion injury was smaller in the obese Zucker diabetic fatty rat [ 11 , 12 ] and the lean Goto–Kakizaki rat [ 12 ], whereas, in the db / db mouse, infarct size was larger [ 13 ]. In the present study, we hypothesized that MS would...

...Giuseppe Fusai; George K. Glantzounis; Tarek Hafez; Wenxuan Yang; Alberto Quaglia; Hemant Sheth; Sanjeev Kanoria; Harry Parkes; Alexander Seifalian; Brian R. Davidson Steatotic livers are highly susceptible to I/R (ischaemia/reperfusion) injury and, therefore, the aim of the present study...

...Rahul S. KOTI; Wenxuan YANG; Georgios GLANTZOUNIS; Alberto QUAGLIA; Brian R. DAVIDSON; Alexander M. SEIFALIAN IPC (ischaemic preconditioning) may protect the steatotic liver, which is particularly susceptible to I/R (ischaemia/reperfusion) injury. Hepatic steatosis was induced in Sprague–Dawley...