... and DNA structure and function. Ischaemia-reperfusion injury is a multifaceted pathological state characterised by excessive production of mROS. There is a significant clinical need for therapies mitigating mitochondrial oxidative stress. To date, a variety of strategies have been investigated, ranging...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute kidney injury endothelial function ischaemia-reperfusion injury microRNA vasculature Canadian Institutes of Health Research...

... and reperfusion, which represents an acute crisis of energy provision. Evidence is presented from preclinical models that augmentation of the CK system can reduce ischaemia–reperfusion injury and improve functional recovery. Energetic impairment is also a hallmark of chronic heart failure, in particular, down...

...Laurie Bruzzese; Gwénaël Lumet; Donato Vairo; Claire Guiol; Régis Guieu; Alice Faure Ischaemia–reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and chronic kidney disease, which consists of cellular damage and renal dysfunction. AKI is a major complication...

... ligand ischaemia-reperfusion injury renal fibrosis Chronic kidney disease (CKD) is characterized by persistent inflammation and a gradual increase in fibrosis including glomerulosclerosis and tubulointerstitial fibrosis, ultimately leading to end-stage renal disease (ESRD) regardless...

... 2020 acute kidney injury ischaemia-reperfusion injury TAZ Acute kidney injury (AKI) is one of the most serious conditions worldwide and is associated with mortality [ 1 , 2 ]. The proximal tubule has been considered the primary target of AKI, and tubular injury plays a critical role...

...) . ischaemia-reperfusion injury inflammation Mast cell MCs are functionally much more diverse than previously understood and implicated in the pathogenesis of several types of I/R injury. In mouse models of myocardial infarction, the extent of tissue damage is correlated with MC degranulation, following...

... of the study, potential molecular mechanisms of mitochondrial fission, consequences of the fission, and future research directions. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiomyocytes ischaemia-reperfusion injury mitochondria...

... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC-BY-NC-ND) . 4-hydroxy- trans -2-nonenal Alda-1 ALDH2 intestine ischaemia–reperfusion injury multiple organ dysfunction syndrome • Many studies demonstrate that activation...

... , A.P. ( 2015 ) The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury . J. Mol. Cell. Cardiol. 78 , 129 – 141 10.1016/j.yjmcc.2014.08.018 22 Kašparová , D. , Neckář , J. , Dabrowská , L. , Novotný , J...