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Clin Sci (Lond) (1994) 86 (2): 133–139.
Published: 01 February 1994
..., such as isoprenaline or forskolin, is as much as 40% of the methacholine-induced sweat rate at 1 week of age, but falls to 10% by 6 weeks of age despite the fact that the agonist-induced tissue accumulation of cyclic AMP expressed on a per μg of protein basis triples with age over the same period. 4. A marked K...
Clin Sci (Lond) (1993) 84 (1): 11–19.
Published: 01 January 1993
...; moreover, the renin-stimulating action of parathyroid hormone may be mediated through the inhibition of calcium influx.s 7 9 1992 10 9 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 angiotensin I assay calcium isoprenaline parathyroid hormone renin...
Clin Sci (Lond) (1989) 76 (3): 283–287.
Published: 01 March 1989
... pathway in secretory cells is likely to be involved in the pathophysiology of the disease. 2. We have compared responsiveness to β-adrenergic stimulation in vivo by infusing isoprenaline locally into peripheral veins of CF patients and control subjects; the dorsal hand vein technique was used to measure...
Clin Sci (Lond) (1988) 75 (3): 285–291.
Published: 01 September 1988
...P. I. Mansell; I. W. Fellows; A. T. Birmingham; I. A. Macdonald 1. The cardiovascular and metabolic responses to low doses of isoprenaline (15 and 5 ng min −1 kg −1 body weight infused over 30 min) were determined in six healthy males. The study was performed to investigate whether there were...
Clin Sci (Lond) (1985) 69 (6): 647–653.
Published: 01 December 1985
...O. Binah; A. Bomzon; L. M. Blendis; D. Mordohovich; O. S. Better 1. Patients with obstructive jaundice are susceptible to postoperative shock. To clarify the mechanism of this phenomenon, we compared the contractile response to isoprenaline of isolated ventricular preparations from three groups...
Clin Sci (Lond) (1985) 69 (4): 483–492.
Published: 01 October 1985
... to β-adrenoceptor stimulation was also determined in each subject by measurement of heart rate responses to bolus injections of isoprenaline. 2. Both periods of mental stress were associated with significant increases in systolic and diastolic blood pressures, heart rate and plasma adrenaline...
Clin Sci (Lond) (1984) 66 (6): 697–699.
Published: 01 June 1984
...D. Fitzgerald; V. Doyle; J. G. Kelly; K. O'Malley 1. The heart rate response to isoprenaline in 11 subjects aged 19–46 years was compared with lymphocyte β-adrenoceptor numbers and lymphocyte cyclic AMP responsiveness. 2. The dose of isoprenaline required to increase heart rate by 25 beats/min...
Clin Sci (Lond) (1981) 61 (6): 679–684.
Published: 01 December 1981
...H. K. Richards; A. R. Noble; K. A. Munday 1. The effect of the β-adrenoceptor agonist isoprenaline on the secretion of active and inactive renin was investigated in two preparations. 2. in ten urethane-anaesthetized rabbits isoprenaline, given as a renal artery infusion, had relatively minor...
Clin Sci (Lond) (1981) 61 (s7): 121s–123s.
Published: 01 December 1981
..., and ornithine decarboxylase (ODC) activity of SMC were increased in SHR and SHRSP in comparison with WKY rats. 4. The application of isoprenaline but not noradrenaline to the culture media increased ODC activity acutely in SMC from WKY rats and this increase was blocked by propranolol. 5. These results indicate...
Clin Sci (Lond) (1981) 61 (5): 535–539.
Published: 01 November 1981
...J. P. M. Finberg; H. A. Syrop; O. S. Better 1. The pressor and heart rate response to angiotensin II, noradrenaline, isoprenaline, tyramine and β-phenylethylamine were examined before and after bile-duct ligation in conscious trained dogs. 2. The pressor response to angiotensin II was markedly...
Clin Sci (Lond) (1981) 60 (6): 659–666.
Published: 01 June 1981
... collateral resistance by an average of 135%. Glyceryl trinitrate (0.5 mg sublingually) reduced collateral resistance by an average of 45%. Hydrallazine and isoprenaline had an inconsistent dilator effect; the direct action of these drugs may have been offset by the reduction in distending pressure which...
Clin Sci (Lond) (1981) 60 (5): 571–577.
Published: 01 May 1981
...P. Van Brummelen; F. R. Bühler; W. Kiowski; F. W. Amann 1. Changes in forearm blood flow to intra-arterial infusion of isoprenaline and the chronotropic response to intravenous boluses of isoprenaline were measured in 15 healthy volunteer subjects, eight younger than 25 years and seven older than...
Clin Sci (Lond) (1981) 60 (4): 399–404.
Published: 01 April 1981
...C. J. Mathias; H. L. Frankel; I. B. Davies; V. H. T. James; W. S. Peart 1. The effect of endogenous sympathetic stimulation (induced by urinary bladder stimulation) and intravenous infusion of noradrenaline and isoprenaline on blood pressure, heart rate and levels of plasma renin activity...
Clin Sci (Lond) (1980) 59 (s6): 365s–368s.
Published: 01 December 1980
...M. A. Saragoca; R. C. Tarazi 1. In response to graded infusions of isoprenaline, adult spontaneously hypertensive rats (20-24 weeks old) showed diminished responses of left ventricular contractile indices, diminished chronotropic responses and impairment of left ventricular relaxation rate...
Clin Sci (Lond) (1980) 59 (s6): 457s–460s.
Published: 01 December 1980
... cardiac hypertrophy hypertension isoprenaline noradrenaline osmotic minipump α- or β-receptor-blocking agents Clinical Science (1980) 5 9 , 4 5 7 ~ 4 6 0 s 457s Effect of P-receptor-blocking agents on cardiovascular structural changes in spontaneous and noradrenaline-induced hypertension in rats Y...
Clin Sci (Lond) (1980) 58 (5): 357–364.
Published: 01 May 1980
... by different bandwidths. Therefore we derived an index, the mean ejection time, which is influenced by changes in the shape of the systolic portion of the volume curve but is unchanged when measured from curves treated by different filter bandwidths. 3. We infused isoprenaline (2 μg/min; eight patients...
Clin Sci (Lond) (1979) 57 (s5): 161s–163s.
Published: 01 December 1979
...R. Vandongen; K. D. Strang; Marianne H. Poesse; W. H. Birkenhager 1. The effect of α-adrenergic stimulation, with phenylephrine, on isoprenaline-provoked renin secretion was studied in the isolated perfused rat kidney. 2. Infusion of phenylephrine increased renal perfusion pressure and prevented...
Clin Sci (Lond) (1979) 57 (5): 401–407.
Published: 01 November 1979
... of angiotensin III was 20 fmol/ml (sd 15; n = 8), and angiotensin II-like activity was 60 fmol/ml (sd 35; n = 8). 4. The β-sympathomimetic amine isoprenaline caused a time- and dose-dependent increase in plasma angiotensin III and angiotensin II-like activities. 5. Under the conditions studied angiotensin III...
Clin Sci Mol Med (1978) 54 (3): 283–289.
Published: 01 March 1978
... 1978 α-adrenoreceptor agonists β-adrenoreceptor blockade asthma atropine bronchi isoprenaline methoxamine propranolol Clinical Science and Molecular Medicine, (1978), 54, 283-289 The effect of -adrenoreceptor stimulation on the airways of normal and asthmatic man P. D. SNASHALL, FRANCES...
Clin Sci Mol Med (1976) 51 (2): 133–139.
Published: 01 August 1976
... curve for the upstream airways was such that the computed resistance of these airways fell. Thus it appears that the airways comprising the upstream segment were dilated. airways disease bronchodilators expiratory flow rates gas density isoprenaline 24 12 1975 © 1976...
Clin Sci Mol Med (1975) 49 (1): 73–76.
Published: 01 July 1975
...R. Vandongen 1. The effect of antidiuretic hormone (ADH) on isoprenaline-stimulated renin secretion was examined in the isolated rat kidney perfused with modified Krebs-Ringer saline. 2. Intrarenal infusion of ADH effectively prevented stimulation of renin secretion by isoprenaline whilst...
Clin Sci Mol Med (1975) 48 (s2): 31s–32s.
Published: 01 January 1975
... isoprenaline-induced and glucagon-induced stimulation of renin secretion. © 1975 The Biochemical Society and the Medical Research Society 1975 calcium flux glucagon isoprenaline kidney lanthanum noradrenaline renin Clinical Science and Molecular Medicine (1975) 48, 31 s-32s. Blockade of renin...
Clin Sci Mol Med (1974) 46 (1): 75–87.
Published: 01 January 1974
...G. Jerums; D. J. Galton; C. Gilbert 1. Isoprenaline (1 μmol/l) and glucagon (1 μmol/l) raised the levels of cyclic AMP in isolated adipose cells of the rat to a maximum after incubation for approximately 15 min. 2. The effect of glucagon was impaired by pretreatment of adipose cells with trypsin...
Clin Sci (1972) 43 (6): 759–769.
Published: 01 December 1972
...J. F. Cade; M. C. F. Pain 1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline. 2...
Clin Sci (1972) 42 (6): 725–733.
Published: 01 June 1972
...T. W. Astin 1. Airways resistance and lung volume were measured in twenty-five patients with chronic bronchitis and fifteen patients without chest disease before and after the inhalation of isoprenaline. Similar measurements were made on fourteen of these patients with chronic bronchitis and twelve...