... (kallikrein–kinin system) is implicated in physiological vasodilatation [ 6 , 7 ], anti-coagulation [ 8 ], inflammation [ 9 ] and angiogenesis [ 10 ]. Previous studies have documented the role of this system in limiting organ damage in the setting of haemodynamic, hyperglycaemic or ischaemic aggression [ 7...

... in blood pressure. 6 2 1992 21 2 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 angiotensin II kallikrein-kinin system high-molecular-mass kininogen renin-angiotensin system T-kininogen Clinical Science (1992) 83, 12-22 (Printed i n Great Britain) 13...

... excretion could be the result of a reduction in proximal kininase activity induced by the higher dose. Key words: angiotensin-converting enzyme, angiotensin- converting enzyme inhibitors, hypertension, kallikrein- kinin system, kidney, kininases. Abbreviations: ACE, angiotensin-converting enzyme; AP...

...- tion during the developmental phase of hypertension in young SHR is similar to the reduction observed in the renal tissue. Key words: hypertension, kallikrein-kinin system, kidney, renal kallikrein, urinary kallikrein. INTRODUCTION Glandular kallikrein is a serine protease that produces kinins from...

... diuresis frusemide kallikrein–kinin system natriuresis ClinicalScience( 1987) 12, 449-454 449 Amiloride inhibits the rise of urinary kallikrein excretion induced by frusemide administration in the rat . L. F. 0. O B I U AND M. MARIN-GSZ* Department of Physiology and Biochemistry, University of Ilorin...

... influence did not subside after repeated injections. Correspondence: Dr L. F. 0. Obika, Department of Physiology and Biochemistry, University of Ilorin, Ilorin, Kwara, Nigeria. Key words: adrenalectomy, diuresis, deoxycorti- costerone acetate, frusemide, kallikrein-kinin system, natriuresis. Abbreviations...

... not indicating the true changes in the activity of the renal kallikrein-kinin system within the kidney. Kinin excretion in urine was not correlated with kallikrein excretion but with changes in diuresis. Thus it might be suggested that the renal kallikrein-kinin system could be involved by kinins...

... as in other models of renovascular hypertension: elevation in the ischaemic kidney and reduction in the non-ischaemic one. 5 8 1981 5 4 1982 4 5 1982 experimental hypertension kallikrein-kinin system plasma renin activity renal kallikrein renal renin © 1982 The Biochemical...

..., and that this release can be hormonally regulated by a mechanism involving prostaglandin synthesis. arachidonic acid indomethacin isolated kidney kallikrein-kinin system renal prostaglandins renal kallikrein © 1982 The Biochemical Society and the Medical Research Society 1982 Clfnical Science (1982...

..., but the difference did not reach statistical significance. 4. In this experiment no relationship was observed between the activity of the renal kallikrein-kinin system and the plasma aldosterone concentration. 5. The transient increase in urinary kallikrein excretion is interpreted as a wash-out effect of renal...

...A. Overlack; K. O. Stumpe; M. Kuhnert; I. Heck 1. The effect of aprotinin-induced blockade of the kallikrein-kinin system on haemodynamic and biochemical responses to converting enzyme inhibition by SQ 14 225 was evaluated in 26 patients with essential hypertension. 2. SQ 14 225 lowered blood...

... blood—brain barrier converting-enzyme inhibitor YS 980 enkephalins kallikrein—kinin system Clinical Science (1979) 57 ,157~160s A novel orally active converting-enzyme inhibitor Y S 980: effects on blood pressure in spontaneously hypertensive rats TH. U N G E R , R. W. R O C K H O L D , K . S C H...