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Keyword: kidney
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Articles
Clin Sci (Lond) (2019) 133 (2): 167-180.
Published: 18 January 2019
...Mathilde L. Bonnemaison; Eileen S. Marks-Nelson; Erika I. Boesen Systemic lupus erythematosus (SLE) is an autoimmune disease predominantly affecting women and often leading to lupus nephritis and kidney damage. Endoplasmic reticulum (ER) stress has been implicated in several forms of kidney...
Articles
Clin Sci (Lond) (2019) 133 (1): 41-54.
Published: 03 January 2019
... interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine...
Articles
Clin Sci (Lond) (2018) 132 (17): 1977-1994.
Published: 14 September 2018
...Meg L. McFetridge; Mark P. Del Borgo; Marie-Isabel Aguilar; Sharon D. Ricardo Chronic kidney disease (CKD) is a major and growing public health concern with increasing incidence and prevalence worldwide. The therapeutic potential of stem cell therapy, including mesenchymal stem cells (MSCs) and...
Articles
Clin Sci (Lond) (2018) 132 (11): 1179-1197.
Published: 15 June 2018
...Sarah C. Ray; Bansari Patel; Debra L. Irsik; Jingping Sun; Hiram Ocasio; Gene R. Crislip; Chunhua H. Jin; JianKang Chen; Babak Baban; Aaron J. Polichnowski; Paul M. O’Connor Sodium bicarbonate (NaHCO 3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet the...
Articles
Clin Sci (Lond) (2016) 130 (15): 1307-1326.
Published: 29 June 2016
... 4 2016 6 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 AT2 receptor AT2R agonism cardiovascular compound 21 kidney The biological actions of the renin–angiotensin system (RAS) are regarded to be primarily...
Articles
Clin Sci (Lond) (2014) 127 (7): 423-433.
Published: 17 June 2014
.... Correspondence: Professor Carol A. Pollock (email carol.pollock@sydney.edu.au ). 29 1 2014 24 3 2014 16 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 diabetic nephropathy calcium-activated potassium channel inflammatory cell K Ca 3.1 kidney renal...
Articles
Clin Sci (Lond) (2014) 127 (1): 15-17.
Published: 10 March 2014
... in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue of Clinical Science , Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were...
Articles
Clin Sci (Lond) (2014) 127 (1): 19-31.
Published: 10 March 2014
... blockers are renoprotective and down-regulate ILK in experimental kidney disease, but the involvement of ILK in the actions of AngII in the kidney has not been addressed. Therefore we have investigated whether ILK signalling modulates the kidney response to systemic AngII infusion in wild-type and ILK...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (10): 685-694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
Articles
Clin Sci (Lond) (2014) 126 (5): 315-328.
Published: 25 October 2013
... factors and agents that control nephrin and Neph3 gene expression. Correspondence: Dr Sanna Lehtonen (email sanna.h.lehtonen@helsinki.fi ). 28 5 2013 9 8 2013 21 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 glomerulus kidney KIRREL2 (kin...
Articles
Clin Sci (Lond) (2013) 124 (12): 701-710.
Published: 26 February 2013
... transgenic lines demonstrated similar elevations of BP (blood pressure) and plasma potassium after 4 weeks of TG induction. Withdrawal of doxycycline switched off mutant TG expression and the disappearance of the PHAII phenotype. Western blotting of microdissected kidney nephron segments confirmed that...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2013) 124 (6): 351-370.
Published: 27 November 2012
... by its action on a restricted number of tissues; however, it has now become clear that this hormone controls an array of cellular processes in many different tissues. The present review will focus on the role of insulin in the kidney in health and disease. Correspondence: Dr Richard Coward...
Articles
Clin Sci (Lond) (2013) 124 (3): 191-202.
Published: 17 October 2012
... species) have been implicated in the development of diabetic nephropathy. Of the Nox isoforms in the kidney, Nox4 is important because of its renal abundance. In the present study, we tested the hypothesis that GKT136901, a Nox1/4 inhibitor, prevents the development of nephropathy in db / db (diabetic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (6): 333-346.
Published: 29 May 2012
...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2). The...
Articles
Clin Sci (Lond) (2012) 123 (1): 1-14.
Published: 12 March 2012
...Anke L. Lameris; Leo A. Monnens; René J. Bindels; Joost G. J. Hoenderop Magnesium (Mg 2+ ) balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a broad variety of drugs. Diuretics, modulators of the EGFR (epidermal growth factor...
Articles
Clin Sci (Lond) (2012) 122 (11): 513-527.
Published: 10 February 2012
... hypertension kidney myocardial ischaemia/reperfusion injury soluble epoxide hydrolase inhibitor Ischaemic heart disease is the leading cause of mortality in industrialized nations [ 1 ]. Hypertension and hypertension-induced LVH [LV (left ventricular) hypertrophy] have been recognized in the...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 122 (10): 439-447.
Published: 20 January 2012
... microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges...
Articles
Clin Sci (Lond) (2012) 122 (6): 281-288.
Published: 11 November 2011
... developmental programming extracellular fluid hyperphagia kidney salt appetite Prenatal exposure to an adverse environment has a marked impact upon the developing kidney. People whose birthweights were towards the lower end of the normal range have fewer nephrons [ 1 ] and are at greater risk of...
Articles
Clin Sci (Lond) (2010) 118 (4): 269-279.
Published: 16 November 2009
...Elena Velkoska; Rachael G. Dean; Luke Burchill; Vicki Levidiotis; Louise M. Burrell Alterations within the RAS (renin–angiotensin system) are pivotal for the development of renal disease. ACE2 (angiotensin-converting enzyme 2) is expressed in the kidney and converts the vasoconstrictor AngII...
Articles
Clin Sci (Lond) (2010) 118 (1): 71-77.
Published: 02 October 2009
...Paul R. Kalra; Jonathan R. Clague; Andrew J. Coats; Stefan D. Anker; Philip A. Poole-Wilson; Allan D. Struthers CNP (C-type natriuretic peptide) is a vasodilatory peptide produced by vascular endothelium and the human heart with a short half-life. CNP has been identified within the human kidney...
Articles
Clin Sci (Lond) (2010) 118 (1): 1-18.
Published: 28 September 2009
...Henrik Dimke; Joost G. Hoenderop; René J. Bindels The kidney plays an important role in maintaining the systemic Ca 2+ and Mg 2+ balance. Thus the renal reabsorptive capacity of these cations can be amended to adapt to disturbances in plasma Ca 2+ and Mg 2+ concentrations. The reabsorption of Ca 2...
Articles
Clin Sci (Lond) (2009) 117 (2): 75-84.
Published: 15 June 2009
... + . Western blotting and quantitative PCR showed that NKCC2 expression was increased, whereas NCC mRNA was not up-regulated. Na + /K + ATPase α 1 subunit expression did not differ from controls; however, there was a significant reduction in whole kidney pump activity (23.4±1.8 and 17.7±1.2 nmol of...
Articles
Clin Sci (Lond) (2008) 115 (2): 57-68.
Published: 12 June 2008
... (phenylephrine) and ACh (acetylcholine) in isolated perfused kidneys were measured. NO levels were calculated as 24-h urinary excretion of nitrites, ROS as TBARS (thiobarbituric acid-reacting substances), and peroxynitrite formation as the renal expression of nitrotyrosine. BDL rats had progressive sodium...
Articles
Clin Sci (Lond) (2008) 114 (9): 589-590.
Published: 02 April 2008
... 2008 glucagon glucose tolerance insulin deficiency kidney microalbuminuria Type 2 diabetes The existence of a second pancreatic hormone, one that raises plasma glucose concentrations, in addition to the glucose-lowering hormone insulin was deduced early in the 20th century and fully...
Articles
Clin Sci (Lond) (2008) 114 (9): 591-601.
Published: 02 April 2008
... increased serum glucagon by 129% ( P <0.05), raised systolic BP (blood pressure) by 21 mmHg ( P <0.01), elevated fasting blood glucose by 42% ( P <0.01), impaired glucose tolerance ( P <0.01), increased the kidney weight/body weight ratio ( P <0.05) and 24 h urinary albumin excretion by 108...
Articles
Clin Sci (Lond) (2008) 114 (4): 305-311.
Published: 15 January 2008
... compared with SHRs ( P <0.0001). UAE was significantly higher in male (7-fold) compared with female MWF rats (162.6±15.9 compared with 24.0±5.5 mg/24 h respectively; P <0.0001), and only male MWF rats developed significant glomerulosclerosis and tubulointerstitial damage in the kidney ( P <0.0001...
Articles
Clin Sci (Lond) (2007) 113 (7): 297-311.
Published: 03 September 2007
... the literature since Y2K (year 2000) is provided, with a general overview of PGs and their synthesis enzymes, and then specific considerations of each PG/prostanoid receptor system in the kidney. Correspondence: Dr Richard L. Hébert (email rlhebert@uottawa.ca ). 14 3 2007 11 4 2007...
Articles
Clin Sci (Lond) (2007) 113 (5): 251-258.
Published: 01 August 2007
... 2 4 2007 2 5 2007 2 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 α-adducin blood pressure hypertension kidney physical activity polymorphism postexercise hypotension sodium Adducin is an essential protein for assembly of the spectrin...
Articles
Clin Sci (Lond) (2007) 112 (12): 583-597.
Published: 14 May 2007
... © 2007 Biochemical Society 2007 artery blood pressure central nervous system dopamine receptor hypertension kidney sodium homoeostasis Essential hypertension affects 25% of the adult population and constitutes a major risk factor for stroke, myocardial infarction, heart failure and...
Articles
Clin Sci (Lond) (2007) 112 (6): 337-344.
Published: 12 February 2007
... 2006 3 10 2006 The Biochemical Society 2007 arterial hypotension blood pressure circadian variation kidney normal pressure glaucoma orthostatic test sodium handling For several decades, COAG (chronic open angle glaucoma) has been considered as a disease essentially due to...
Articles
Clin Sci (Lond) (2006) 111 (1): 61-70.
Published: 14 June 2006
... protein von Hippel–Lindau, which leads to constitutively elevated HIF-1. We hypothesized that AM is increased in CC-RCC tumours and that AM is a plasma biomarker for CC-RCC. Tumours and non-malignant kidney tissue were obtained from patients that underwent unilateral nephrectomy. Blood samples were drawn...
Articles
Clin Sci (Lond) (2006) 111 (1): 21-34.
Published: 14 June 2006
...) hypertension kidney metabolic syndrome obesity Eicosanoids refer to C 20 metabolites generated by three major enzymatic pathways: COX (cyclo-oxygenase), LOX (lipoxygenase) and CYP450 (cytochrome P450). The major biological eicosanoids are derived from arachidonic acid released from membrane...
Articles
Clin Sci (Lond) (2005) 109 (6): 503-511.
Published: 23 November 2005
... 10 viral particles) significantly increased β-AR density in the kidney, lung and liver, but was without effect on physiological and plasma biochemical parameters. Moreover, this dose of virus did not cause any of the potential toxic responses of viral administration, such as inflammation and tissue...
Articles
Clin Sci (Lond) (2004) 107 (2): 159-165.
Published: 27 July 2004
...@ucl.ac.uk ). 17 2 2004 15 3 2004 31 3 2004 The Biochemical Society 2004 aluminium Bowman's space kidney loop of Henle micropuncture proximal tubule Aluminium, the most abundant metal in the Earth's crust, is ingested from a variety of sources and undergoes partial...
Articles
Clin Sci (Lond) (2004) 106 (3): 337-343.
Published: 01 March 2004
...Leila M. M. PEREIRA; Daniele G. BEZERRA; Denise L. MACHADO; Carlos A. MANDARIM-DE-LACERDA Stereological structural alterations of the heart and kidney were studied in four groups ( n =5) of spontaneously hypertensive rats (SHRs) treated for 30 days: (i) control, (ii) N G -nitro- L -arginine methyl...
Articles
Clin Sci (Lond) (2003) 105 (2): 235-242.
Published: 01 August 2003
... arteries and kidneys of hypertensive rats. Sprague—Dawley rats were divided into four groups ( n =6/group): control (vehicle), angiotensin II (Ang II; 150 ng/kg of body weight per min subcutaneously), quinidine [Ang II (150 ng/kg of body weight per min)+quinidine (5 mg/kg of body weight per day in food...
Articles
Clin Sci (Lond) (2003) 104 (6): 607-614.
Published: 01 June 2003
... angiotensin II (30 ng·min -1 ·kg -1 ). Under control conditions, renal haemodynamic and tubular function did not differ. However, when challenged with angiotensin II, LP rats responded with a greater decrease in glomerular filtration rate than did NP rats [NP, 2.0±0.2 ml·min -1 ·g -1 kidney weight ( n =9); LP...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 44S-47S.
Published: 01 September 2002
... ET-1 gene, prepro-ET-1, in kidneys of (Epo+) mice, we generated crossbred mice overexpressing the human EPO gene with mice carrying a reporter gene construct expressing the LacZ gene under the control of the human prepro-ET-1 promotor sequence (LacZ+/Epo+). For comparison, we generated (LacZ+/Epo...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 254S-257S.
Published: 01 September 2002
... Conference on Endothelin was held at the University of Edinburgh, UK, 16-19 September 2001 Dr A. Wada (e-mail wada@belle.shiga-med.ac.jp ). © 2002 The Biochemical Society and the Medical Research Society 2002 hormone kidney sodium 254S Clinical Science (2002) 103 (Suppl. 48), 254S 257S...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 25S-30S.
Published: 01 September 2002
... factor κB (NF-κB) and activator protein-1 (AP-1) were increased in kidneys from aldosterone-infused rats. The role of ET-1 in these processes was evaluated by treating rats with the ET A -receptor blocker, BMS 182874. Rats were infused with aldosterone (0.75 µ g/h) via a mini-osmotic pump and were given...
Articles
Clin Sci (Lond) (2002) 103 (s2002): 258S-262S.
Published: 01 September 2002
... Medical Research Society 2002 cGMP endothelin-1 heart failure kidney natriuretic peptide phosphodiesterase inhibitor 258S Clinical Science (2002) 103 (Suppl. 48), 258S 262S (Printed in Great Britain) Chronic administration of phosphodiesterase type 5 inhibitor suppresses renal production of...
Articles
Clin Sci (Lond) (2001) 101 (2): 121-130.
Published: 18 June 2001
... HU3 2JZ, U.K. (e-mail sunil.bhandari@medix-uk.com ). 4 12 2000 20 3 2001 18 4 2001 The Biochemical Society and the Medical Research Society © 2001 2001 ion channel inward rectifier kidney mutation potassium selectivity filter 121Clinical Science (2001) 101, 121...
Articles
Clin Sci (Lond) (2000) 99 (6): 541-546.
Published: 21 November 2000
...Kazuhito TOTSUNE; Kazuhiro TAKAHASHI; Harald S. MACKENZIE; Osamu MURAKAMI; Zenei ARIHARA; Masahiko SONE; Toraichi MOURI; Barry M. BRENNER; Sadayoshi ITO Adrenomedullin is a vasodilator peptide produced in various organs, including heart and kidney. A novel adrenomedullin receptor complex has...
Articles
Clin Sci (Lond) (2000) 99 (4): 285-292.
Published: 31 August 2000
... not result in hypocalcaemia. Plasma parathyroid hormone activity was not significantly different between the two groups, and there was no evidence of altered tissue content of magnesium in kidney, liver, heart, skeletal muscle or bone. The study confirms that hypomagnesaemia is a significant side...
Articles
Clin Sci (Lond) (2000) 98 (5): 611-617.
Published: 26 April 2000
... Society © 2000 2000 aldosterone arterial pressure cardiac output kidney liver cirrhosis portal pressure renin sodium retention 611Clinical Science (2000) 98, 611 617 (Printed in Great Britain) Haemodynamic and renal evolution of the bile duct-ligated rat Concepcio! n MARTI!NEZ-PRIETO*, M...
Articles
Clin Sci (Lond) (1999) 97 (4): 457-465.
Published: 24 August 1999
... cyclo-oxygenase exercise indomethacin kidney nabumetone non-steroidal anti-inflammatory drugs prostaglandins renal failure renal haemodynamics renin sodium excretion 457Clinical Science (1999) 97, 457 465 (Printed in Great Britain) Non-steroidal anti-inflammatory drugs and renal response to...
Articles
Clin Sci (Lond) (1999) 97 (3): 283-290.
Published: 15 July 1999
... suggested that it can directly alter transport processes at the plasma membrane. To examine this possibility in a physiological context, we determined Na + /K + -ATPase activity in erythrocytes from two groups of subjects receiving CsA treatment: group I consisted of kidney transplant patients, and group II...
Articles
Clin Sci (Lond) (1998) 95 (5): 595-602.
Published: 01 November 1998
... kidney natriuretic peptide receptor 595Clinical Science (1998) 95, 595 602 (Printed in Great Britain) Different effects of atrial and C-type natriuretic peptide on the urinary excretion of endothelin-1 in man Giorgio LA VILLA, Massimo MANNELLI*, Chiara LAZZERI, Sabrina VECCHIARINO, Maria Laura DE FEO...
Articles
Clin Sci (Lond) (1998) 95 (5): 603-609.
Published: 01 November 1998
... 70-fold increase of naproxen accumulation in the kidney with a subsequent renal release of the active metabolite naproxen–lysine. 2. In the present study we questioned whether naproxen–lysozyme is active in the rat kidney, inhibiting the urinary excretion of prostaglandin E 2 and renal sodium and...
Articles
Clin Sci (Lond) (1998) 95 (4): 409-418.
Published: 01 October 1998
...Cornelis H. C. DEJONG; Carlo F. M. WELTERS; Nicolaas E. P. DEUTZ; Erik HEINEMAN; Peter B. SOETERS 1. Arginine can be produced in the kidney from citrulline. An important source of circulating citrulline is the intestinal breakdown of glutamine. Consequently, partial enterectomy leads to decreased...