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Keywords: kidney fibrosis
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Clin Sci (Lond) (2023) 137 (5): 317–331.
Published: 01 March 2023
... pathway. Silencing of Meg3 suppressed LPS-induced cytokine production of CCL-2 and CXCL-2 and the activation of p38 MAPK pathway in vitro and ameliorated kidney fibrosis in mice with obstructive nephropathy. Together, these findings identify a proinflammatory role of lncRNA Meg3 in CKD and suggest a novel...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (5): 411–423.
Published: 17 February 2017
... Smad2 and Smad3 activation and plays a protective role in kidney fibrosis [ 8 ]. The ERK/MAPK signalling pathway has also been identified as a regulator of kidney damage leading to mesangial hypertrophy, activated by hyperglycaemia and an elevated TGF-β1 expression, as has been reported in experimental...
Includes: Supplementary data