... as a bolus during reperfusion in the absence or presence of HOE-140 (a B 2 R antagonist) or DALBK (des-Arg 9 -Leu 8 -BK) (a B 1 R antagonist) respectively. Liver viability was analysed by glucose release and bile secretion. The PHR to kinins did not change. Cell death was higher in the DABK group and its...

...Alastair MacGilchrist; Kathrine J. Craig; Peter C. Hayes; Allan D. Cumming 1. Previous studies have documented activation of protease enzymes, such as the plasma kallikrein-kinin system, in hepatic cirrhosis. Increased plasma kinin generation could contribute to pathological systemic vasodilatation...

... 8.5) in the presence of peptidase inhibitors for 60 min. 2. The kallikrein-like enzyme showed optimum activity in the range pH 7.0-9.0. The rate at which it releases kinin is similar to the release of kinin by kallikrein and trypsin. The release is unaffected by incubation of the enzyme with trypsin...