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Keywords: l-alanine
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Articles

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Grainne A. Cunningham, Neville H. Mcclenaghan, Peter R. Flatt, Philip Newsholme
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (5): 447–455.
https://doi.org/10.1042/CS20050149
Published: 24 October 2005
...Grainne A. Cunningham; Neville H. Mcclenaghan; Peter R. Flatt; Philip Newsholme Acute effects of nutrient stimuli on pancreatic β-cell function are widely reported; however, the chronic effects of insulinotropic amino acids, such as L -alanine, on pancreatic β-cell function and integrity...
View articletitled, L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis
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Includes: Supplementary data
Articles

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity

Gordon DIXON, John NOLAN, Neville H. McCLENAGHAN, Peter R. FLATT, Philip NEWSHOLME
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (2): 191–199.
https://doi.org/10.1042/CS20030261
Published: 01 February 2004
... of AA were associated with significant decreases in the cellular consumption of D -glucose and L -alanine as well as decreased rates of production of nitric oxide and ammonia. Conversely 24 h exposure to the saturated fatty acid palmitic acid (PA) was found to decrease β-cell viability (by increasing...
View articletitled, Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity
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